Targeting of anticancer drug, using radiosensitive microcapsules via radiotherapy.
Project/Area Number |
20591503
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | Iwate Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SERA Koichiro 岩手医科大学, 医学部, 教授 (00230855)
KAMIYA Tomihiro 独立行政法人日本原子力研究開発機構, 高崎量子応用研究所・ビーム技術開発課, ビーム技術開発室室長 (70370385)
増田 友之 岩手医科大学, 医学部, 教授 (10199698)
|
Project Period (FY) |
2008 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 放射線治療生物学 / Drug delivery system / 放射線 / マイクロカプセル / 薬剤標的療法 / PIXE / PTXE / 放射線生物学 / Drug Delivery System / Drug Delivery System(DDS) |
Research Abstract |
We have developed microcapsules that release anticancer drug with response to radiation. Those microcapsules were injected around the experimental tumors in left hind legs of mice, then radiation was given to tumors. As a result, the antitumor effect was enhanced by synergistic effect between radiation and anticancer drugs, and adverse effect of anticancer drugs was decreased by localization of anticancer drugs by microcapsules.
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Report
(7 results)
Research Products
(50 results)
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[Journal Article] Increa sing antitumor effects of chemoradiotherapy by drug efflux inhibition wit encapsulated RLIP -76. Int.2011
Author(s)
S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, T. Kamiya, T. Sakai, K. Arakawa, M. Saitoh, S. Oikawa and K. Sera.
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Journal Title
Int.J. PIXE
Volume: Vol 21
Pages: 30-36
Related Report
Peer Reviewed
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[Journal Article] INCREASING ANTITUMOR EFFECTS OF CHEMORADIOT HERAPY BY DRUG EFFLUX INHIBITION WITH ENCAPSULATED ANTI-RLIP-762011
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
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Journal Title
Int.J.PIXE
Volume: 21
Pages: 30-36
Related Report
Peer Reviewed
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[Journal Article] Improved Radiosensitive Microcapsules Using H2022011
Author(s)
S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa , K.Sera.
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Journal Title
Int.J.PIXE
Volume: 20
Pages: 30-36
Related Report
Peer Reviewed
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[Journal Article] Improved radiosensitive microcapsules using H2O2.2010
Author(s)
S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
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Journal Title
Improved radiosensitive microcapsules using H2O2.
Volume: Vol 20
Pages: 30-36
Related Report
Peer Reviewed
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[Journal Article] Improved Radiosensitive Microcapsules Using H2O22010
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
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Journal Title
Int.J.PIXE 20
Pages: 30-36
Related Report
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[Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect.2009
Author(s)
S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
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Journal Title
Int. J. Radiation Oncology, Biol. Phys
Volume: Vol 175
Pages: 455-462
Related Report
Peer Reviewed
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[Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect.2009
Author(s)
Harada, Satoshi, Ehara, Shigeru, Ishii, Keizoh, Yamazaki, Hiromichi, Matsuyama, Shigeo, Sakai, Takuro, Obara, Yoshihiro, Sato, Takahiro, Oikawa, Masakazu, Sera, Koichiro.
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Journal Title
Int.J.Radiat.Oncol.Biol.Phys. 75(2)
Pages: 455-462
Related Report
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[Journal Article] Improvement of radiosensitive Liquid-core microcapsules by Yttrium polymerization2007
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
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Journal Title
Int.J.PIXE 17
Pages: 33-40
Related Report
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[Journal Article] Optimizing the radiosensitive liquid core microcapsules for the targeting of chemotherapeutic agents.2007
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
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Journal Title
Nucl.Inst.Meth.Phys.Res.B. 260(1)
Pages: 164-16
Related Report
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[Journal Article] The target-chemotherapy directed by the radiation.2005
Author(s)
Harada, Satoshi, Ehara, Shigeru, Ishii, Keizoh, Yamazaki, Hiromichi, Matsuyama, Shigeo, Sakai, Takuro, Obara, Yoshihiro, Sato, Takahiro, Oikawa, Masakazu, Sera, Koichiro.
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Journal Title
Int.J.PIXE. 15(4)
Pages: 221-224
Related Report
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[Journal Article] The target chemotherapy directed by radiation.2005
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
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Journal Title
Int.J.PIXE 15
Pages: 221-224
Related Report
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[Presentation] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules2012
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
97th Annual Meeting of Radiological Society o f North America
Place of Presentation
Chicago, IL USA
Year and Date
2012-11-25
Related Report
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[Presentation] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decrea sing antitumor effect.2012
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
IJ PIXE
Related Report
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[Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O2 radiosensitization2011
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
96th Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, IL USA
Year and Date
2011-11-28
Related Report
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[Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O_2 radiosensitization2011
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
Organizer
97th Annual Meeting of Radiological Society of North America
Place of Presentation
Chicago, USA
Year and Date
2011-11-27
Related Report
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[Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect2011
Author(s)
Satoshi Harada, Shigeru Ehara, Ke izoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa,Koichiro Sera
Organizer
International Conference of BIO-PIXE 7.
Place of Presentation
Sendai Japan .
Year and Date
2011-10-31
Related Report
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[Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect2011
Author(s)
Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
Organizer
7^<th> International Conference on Bio-PIXE
Place of Presentation
宮城県仙台市
Year and Date
2011-10-31
Related Report
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[Presentation] Inhibition of metastasis and enhancement of antitumor effect us in liquid core nanocapsules via radiotherapy2011
Author(s)
S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
Organizer
53^<rd> Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
Miami, USA
Year and Date
2011-10-26
Related Report
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[Presentation] Imaging and treatment of incipient metastasis using radiosensitive nanocapsules via 2 radiotherapy sessions2011
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
511h Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
Miami FL , USA.
Related Report
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[Presentation] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation -induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization2010
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
95th Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, IL USA
Year and Date
2010-11-28
Related Report
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[Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation.2010
Author(s)
S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
Organizer
95th Annual Meeting of Radiological Society of North America
Place of Presentation
Chicago, USA
Year and Date
2010-11-03
Related Report
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[Presentation] Inhibition of metastasis and enhancement of antitumor effect using liquid core nanocapsules via radiotherapy.2010
Author(s)
S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
Organizer
52nd Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
San Diego USA
Year and Date
2010-10-24
Related Report
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[Presentation] Inhibition Of Metastasis By Using Radiation-Sensitive Microcapsules2010
Author(s)
H Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
Organizer
12th International Conference on Particle Induced X-ray Emission and it is Analytical Applications.
Place of Presentation
Guildford UK
Year and Date
2010-07-01
Related Report
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[Presentation] Inhibition of metastasis by using radiation-sensitive microcapsules2010
Author(s)
S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
Organizer
12^<th> International conference on Particle Induced X-ray Emission and Its Analytical Application.
Place of Presentation
Guildford UK.
Year and Date
2010-07-01
Related Report
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[Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy.2010
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
511h Annual meeting of American Society of Therapeutic Radiation Oncology
Place of Presentation
San Diego CA, USA .
Related Report
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[Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation.2009
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
94th Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, IL USA
Year and Date
2009-11-28
Related Report
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[Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation.2009
Author(s)
S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera.
Organizer
95th Annual Meeting of Radiological Society of North America
Place of Presentation
Chicago, USA.
Related Report
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[Presentation] Masakazu Oikawa, Koichiro Sera , Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation2008
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
Organizer
94th Annual Meeting of Radiological Society of North America.
Place of Presentation
Chicago, IL USA
Year and Date
2008-11-30
Related Report
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[Presentation] Innovation of microcapsules that enables drug targeting through radiotherapy2008
Author(s)
Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera, Innovation of microcapsules tha
Organizer
CAARI 2008
Place of Presentation
Dallas TX USA.
Year and Date
2008-08-10
Related Report
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[Presentation] MEDICAL APPLICATION OF PARTICLE INDUCED X-RAY EMISSION.2008
Author(s)
Harada, Satoshi ; Ehara, Shigeru ; Ishii, Keizoh ; Yamazaki, Hiromichi ; Matsuyama, Shigeo ; Sakai, Takuro ; Obara, Yoshihiro ; Sato, Takahiro ; Oikawa, Masakazu ; Sera, Koichiro
Organizer
International Symposium of Bio PIXE 6.
Place of Presentation
Richland, WA USA
Year and Date
2008-06-20
Related Report
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