Targeting of anticancer drug, using radiosensitive microcapsules via radiotherapy.

• Project/Area Number: 20591503
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Iwate Medical University
• Principal Investigator: HARADA Satoshi 岩手医科大学, 医学部, 講師 (20244931)
• Co-Investigator(Kenkyū-buntansha): SERA Koichiro 岩手医科大学, 医学部, 教授 (00230855) ; KAMIYA Tomihiro 独立行政法人日本原子力研究開発機構, 高崎量子応用研究所・ビーム技術開発課, ビーム技術開発室室長 (70370385) ; 増田 友之 岩手医科大学, 医学部, 教授 (10199698)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 放射線治療生物学 / Drug delivery system / 放射線 / マイクロカプセル / 薬剤標的療法 / PIXE / PTXE / 放射線生物学 / Drug Delivery System / Drug Delivery System(DDS)

Research Abstract

We have developed microcapsules that release anticancer drug with response to radiation. Those microcapsules were injected around the experimental tumors in left hind legs of mice, then radiation was given to tumors. As a result, the antitumor effect was enhanced by synergistic effect between radiation and anticancer drugs, and adverse effect of anticancer drugs was decreased by localization of anticancer drugs by microcapsules.

Research Products

• [Journal Article] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2012)
  • Author(s): S. Harada, S. Ehara, K. Ishii, H. Yamazaki, S. Matsuyama, T. Sato, T. Kamiya, K.sera and Y. Saito.
  • Journal Title: Int.J. PIXE Volume: Vol 22 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decreasing antitumor effect. (2012)
  • Author(s): Satoshi Harada
  • Journal Title: Internationa Journal of PIXE Volume: 22 Pages: 57-64
  • Peer Reviewed
• [Journal Article] Increa sing antitumor effects of chemoradiotherapy by drug efflux inhibition wit encapsulated RLIP -76. Int. (2011)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, T. Kamiya, T. Sakai, K. Arakawa, M. Saitoh, S. Oikawa and K. Sera.
  • Journal Title: Int.J. PIXE Volume: Vol 21 Pages: 30-36
  • Peer Reviewed
• [Journal Article] INCREASING ANTITUMOR EFFECTS OF CHEMORADIOT HERAPY BY DRUG EFFLUX INHIBITION WITH ENCAPSULATED ANTI-RLIP-76 (2011)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
  • Journal Title: Int.J.PIXE Volume: 21 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Improved Radiosensitive Microcapsules Using H202 (2011)
  • Author(s): S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa , K.Sera.
  • Journal Title: Int.J.PIXE Volume: 20 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Improved radiosensitive microcapsules using H2O2. (2010)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • Journal Title: Improved radiosensitive microcapsules using H2O2. Volume: Vol 20 Pages: 30-36
  • Peer Reviewed
• [Journal Article] Improved Radiosensitive Microcapsules Using H2O2 (2010)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Journal Title: Int.J.PIXE 20 Pages: 30-36
• [Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect. (2009)
  • Author(s): S. Harada, S. Ehara, K. Ishii, A. Tanaka, T. Satoh, S. Matsuyama, H. Yamazaki, Y. Komori, T. Kamiya, T. Arakawa, M. Saitoh, M. Oikawa, and K. sera
  • Journal Title: Int. J. Radiation Oncology, Biol. Phys Volume: Vol 175 Pages: 455-462
  • Peer Reviewed
• [Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect. (2009)
  • Author(s): Harada, Satoshi, Ehara, Shigeru, Ishii, Keizoh, Yamazaki, Hiromichi, Matsuyama, Shigeo, Sakai, Takuro, Obara, Yoshihiro, Sato, Takahiro, Oikawa, Masakazu, Sera, Koichiro.
  • Journal Title: Int.J.Radiat.Oncol.Biol.Phys. 75(2) Pages: 455-462
• [Journal Article] Targeted Delivery of Chemotherapeutic Agents by using Improved Radiosensitive Liquid-Core Microcapsules and Assessment of Their Antitumor Effect. (2009)
  • Author(s): S.Harada, et.al.
  • Journal Title: Int.J.Radiation Oncology, Biol.Phys. 75 Pages: 455-462
  • Peer Reviewed
• [Journal Article] Medical Application of Particle Induced x-ray Emission (2008)
  • Author(s): S. Harada, et. al.
  • Journal Title: International Journal of PIXE 4 Pages: 101-110
  • Peer Reviewed
• [Journal Article] Improvement of radiosensitive Liquid-core microcapsules by Yttrium polymerization (2007)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Journal Title: Int.J.PIXE 17 Pages: 33-40
• [Journal Article] Optimizing the radiosensitive liquid core microcapsules for the targeting of chemotherapeutic agents. (2007)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Journal Title: Nucl.Inst.Meth.Phys.Res.B. 260(1) Pages: 164-16
• [Journal Article] The target-chemotherapy directed by the radiation. (2005)
  • Author(s): Harada, Satoshi, Ehara, Shigeru, Ishii, Keizoh, Yamazaki, Hiromichi, Matsuyama, Shigeo, Sakai, Takuro, Obara, Yoshihiro, Sato, Takahiro, Oikawa, Masakazu, Sera, Koichiro.
  • Journal Title: Int.J.PIXE. 15(4) Pages: 221-224
• [Journal Article] The target chemotherapy directed by radiation. (2005)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Journal Title: Int.J.PIXE 15 Pages: 221-224
• [Presentation] Microcapsular maging of malignant tumors and radiation-induced release of liquid-core microcapsules for their treatment. (2013)
  • Author(s): Satoshi Harada
  • Organizer: 13th International Conference on Particle Induced X-ray Emission.
  • Place of Presentation: Hotel Sierra Azul, Gramado, Brazil
• [Presentation] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 97th Annual Meeting of Radiological Society o f North America
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2012-11-25
• [Presentation] I Imaging of premetastatic sites and prophylaxis of metastasis using radiosensitive nanocapsules via radiotherapy. (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 52th Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Boston , USA.
• [Presentation] Decreasing size of radiosensitive nanocapsules from micro to nano, and its increased antitumor effect and decrea sing antitumor effect. (2012)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: IJ PIXE
• [Presentation] I Imaging of premetastatic sites and prophylaxis of metastasis using radiosensitive nanocapsules via radiotherapy. (2012)
  • Author(s): Satoshi Harada
  • Organizer: 54th Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Boston Convention and Exhibition Center, Boston, MA, USA
• [Presentation] Nanoparticle imaging of premetastatic sites and metastasis prophylaxis using radiation-induced release from liquid core nanocapsules (2012)
  • Author(s): Satoshi Harada
  • Organizer: Radiogical Society of North America, 98th Scientific Assembly and Annual Meeting.
  • Place of Presentation: Mc Cormic place, Chicago, IL, USA
• [Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O2 radiosensitization (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 96th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2011-11-28
• [Presentation] Nanoparticle imaging of incipient metastasis and radiation-induced release of liquid-core nanocapsules for treatment of metastatic foci via O_2 radiosensitization (2011)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
  • Organizer: 97th Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-11-27
• [Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Ke izoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa,Koichiro Sera
  • Organizer: International Conference of BIO-PIXE 7.
  • Place of Presentation: Sendai Japan .
  • Year and Date: 2011-10-31
• [Presentation] Decreasing size of radiosensitive capsules from micro to nano, and its increased antitumor effect and decreasing adverse effect (2011)
  • Author(s): Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
  • Organizer: 7^<th> International Conference on Bio-PIXE
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2011-10-31
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect us in liquid core nanocapsules via radiotherapy (2011)
  • Author(s): S.Harada, S.Ehara, K.Ishii, A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera
  • Organizer: 53^<rd> Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Miami, USA
  • Year and Date: 2011-10-26
• [Presentation] Targeting of anticancer drugs using liquid core microcapsules via radiotherapy (2011)
  • Author(s): S.Harada
  • Organizer: 2^<nd> International Conference on Pharmaceutics & Novel Drug Delivery Systems
  • Place of Presentation: Las Vegas, USA
  • Year and Date: 2011-07-08
• [Presentation] Targeting of anticancer drugs using liquid core microcapsules via radiotherapy. (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit
  • Place of Presentation: Las Vegas NV USA .
  • Year and Date: 2011-06-07
• [Presentation] Imaging and treatment of incipient metastasis using radiosensitive nanocapsules via 2 radiotherapy sessions (2011)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Miami FL , USA.
• [Presentation] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation -induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization (2010)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 95th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2010-11-28
• [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation. (2010)
  • Author(s): S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Organizer: 95th Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-03
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect using liquid core nanocapsules via radiotherapy. (2010)
  • Author(s): S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Organizer: 52nd Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: San Diego USA
  • Year and Date: 2010-10-24
• [Presentation] Inhibition Of Metastasis By Using Radiation-Sensitive Microcapsules (2010)
  • Author(s): H Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 12th International Conference on Particle Induced X-ray Emission and it is Analytical Applications.
  • Place of Presentation: Guildford UK
  • Year and Date: 2010-07-01
• [Presentation] Inhibition of metastasis by using radiation-sensitive microcapsules (2010)
  • Author(s): S.Harada, S.Ehara, K.Ishii A.Tanaka, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, T.Sakai, K.Arakawa, M.Saitoh, S.Oikawa, K.Sera.
  • Organizer: 12^<th> International conference on Particle Induced X-ray Emission and Its Analytical Application.
  • Place of Presentation: Guildford UK.
  • Year and Date: 2010-07-01
• [Presentation] 放射線高感受性マイクロカプセルを用いた、転移抑制の試み (2010)
  • Author(s): 原田聡、江原茂、石井慶造, 砂糖隆博
  • Organizer: 第69回日本医学放射線学会総会
  • Place of Presentation: 神奈川横浜
  • Year and Date: 2010-04-08
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2010)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 511h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: San Diego CA, USA .
• [Presentation] Nanoparticle imaging of the metastatic potential of tumor cells and irradiation-induced release of liquid-core nanocapsules for inhibition of metastasis and O2 radiosensitization (2010)
  • Author(s): S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera.
  • Organizer: 96th Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2010)
  • Author(s): S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera.
  • Organizer: 52nd Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: San Diego, USA.
• [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation (2009)
  • Author(s): Satoshi Harada
  • Organizer: 94^<th> Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Mc Cormic place Chicago, IL, USA
  • Year and Date: 2009-11-30
• [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation. (2009)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 94th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2009-11-28
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2009)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 501h Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Chicago IL USA .
  • Year and Date: 2009-11-04
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect using liquid core nanocapsules via radiotherapy. (2009)
  • Author(s): Satoshi Harada
  • Organizer: 51^<st> Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Mc Cormic place Chicago, IL, USA
  • Year and Date: 2009-11-02
• [Presentation] 放射線高感受性マイクロカプセルを使用した、薬剤、および高濃度酸素標的療法 (2009)
  • Author(s): 原田聡
  • Organizer: 第68回日本医学放射線学会総会
  • Place of Presentation: 神奈川県横浜市パシフィコ横浜
  • Year and Date: 2009-04-16
• [Presentation] Radiosensitization by oxygen effect under normal breathing, inhibition of invasion and metastasis, using liquid core microcapsules accumulated through radiation. (2009)
  • Author(s): S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera.
  • Organizer: 95th Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA.
• [Presentation] Inhibition of metastasis and enhancement of antitumor effect usin liquid core nanocapsules via radiotherapy. (2009)
  • Author(s): S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera.
  • Organizer: 51st Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Chicago USA.
• [Presentation] Masakazu Oikawa, Koichiro Sera , Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera
  • Organizer: 94th Annual Meeting of Radiological Society of North America.
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2008-11-30
• [Presentation] Innovation of microcapsules that enables drug targeting through radiotherapy (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Hiromichi Yamazaki, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato, Masakazu Oikawa, Koichiro Sera, Innovation of microcapsules tha
  • Organizer: CAARI 2008
  • Place of Presentation: Dallas TX USA.
  • Year and Date: 2008-08-10
• [Presentation] MEDICAL APPLICATION OF PARTICLE INDUCED X-RAY EMISSION. (2008)
  • Author(s): Harada, Satoshi ; Ehara, Shigeru ; Ishii, Keizoh ; Yamazaki, Hiromichi ; Matsuyama, Shigeo ; Sakai, Takuro ; Obara, Yoshihiro ; Sato, Takahiro ; Oikawa, Masakazu ; Sera, Koichiro
  • Organizer: International Symposium of Bio PIXE 6.
  • Place of Presentation: Richland, WA USA
  • Year and Date: 2008-06-20
• [Presentation] The use of fluoroscopically detectable, tumor-infiltrating microcapsules enables multidrug targeting and endocytosis via radiotherapy. (2008)
  • Author(s): Satoshi Harada, Shigeru Ehara, Keizoh Ishii, Shigeo Matsuyama, Takuro Sakai, Yoshihiro Obara, Takahiro Sato , Masakazu Oikawa, Koichiro Sera
  • Organizer: 50th Annual meeting of American Society of Therapeutic Radiation Oncology
  • Place of Presentation: Boston MA USA.
• [Presentation] Radiosensitization via oxygen effect by using microcapsules with a highly oxygenated liquid core that is released on irradiation (2008)
  • Author(s): S.Harada, S.Ehara., K.Ishii, T.Satoh, S.Matsuyama, H.Yamazaki, T.Kamiya, K.Sera
  • Organizer: 94th Annual Meeting of Radiological Society of North America
  • Place of Presentation: Chicago, USA