| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Whole-body small doses of gamma-ray irradiation suppressed the productivity of pro-inflammatory cytokines and autoantibody, and the ratio of cytotoxic T cells in a few animal models, indicating that attenuation of autoimmune diseases. While, the ratio of Treg cells was significantly induced in all models, suggesting involvement of regulatory T cells in the attenuation by the irradiation. Recently, gene therapy of transcription of Treg gene against autoimmune diseases has been greatly noticed. The radiation therapy with a small-dose could be considered to be one of the promising ways for incurable autoimmune diseases in a near future.
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