A study of the relationship between radiation-induced apoptosis and development of atherosclerosis.

Research Project

Project/Area Number	20591507
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Radiation science
Research Institution	National Institute of Radiological Sciences
Principal Investigator	NAKAJIMA Tetsuo National Institute of Radiological Sciences, 放射線防護研究センター, 主任研究員 (80237271)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	シグナル伝達 / 放射線 / ストレス
Research Abstract	There is a concern that radiation induces atherosclerosis as side effects after radiotherapies. Radiation-induced apoptosis in vascular smooth muscle cells is one of possible mediating processes, because development of atherosclerosis is mediated by oxidative stresses, which can be apoptosis inducers. Radiation-induced apoptosis in the cells was evaluated under the presence of some mediators related to atherosclerosis. Radiation-induced apoptosis of vascular smooth muscle cells was increased by pre-treatment with oxLDL (oxidized low-density lipoproteins). It was also demonstrated that the process by oxLDL mediation involves protein kinase C and lipid peroxides.