Accelerated thrombus organization in the swine abdominal aortic aneurysm model

• Project/Area Number: 20591511
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Tohoku University
• Principal Investigator: SATO Akira Tohoku University, 大学院・医学系・研究科, 講師 (20250764)
• Co-Investigator(Kenkyū-buntansha): GOTO Hitoshi 東北大学, 病院, 助教 (00400333) ; HASHIMOTO Munetake 東北大学, 病院, 助教 (10375040) ; AKAMATSU Daijiro 東北大学, 病院, 助教 (40420012) ; WATANABE Tetsuo 東北大学, 大学院・医学系研究科, 非常勤講師 (50291266)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 動脈瘤 / 血栓 / 組織化 / 線維芽細胞増殖因子 / 第XIII因子 / bFGF / 動脈瘤破裂 / ゼラチンハイドロゲル

Research Abstract

FGF injection to the intra-aneurysmal thrombus accelerated the shrinkage of the aneurysm, migration of myofibroblast and macrophage, and collagen deposition in the swine abdominal aortic aneurysm model.

Research Products

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