| Project/Area Number |
20591512
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Chiba University |
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Principal Investigator |
KIMURA Fumio Chiba University, 大学院・医学研究院, 准教授 (70334208)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Masaru 千葉大学, 大学院・医学研究院, 教授 (70166156)
YOSHIDOME Hiroyuki 千葉大学, 大学院・医学研究院, 講師 (10312935)
KATO Atsushi 千葉大学, 大学院・医学研究院, 助教 (70344984)
TAKEUCHI Dan 千葉大学, 医学部附属病院, 助教 (20400822)
TAKANO Shigetsugu 千葉大学, 医学部附属病院, 助教 (20436380)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 外科総論 / 術後感染症 / 臓器不全 / プロテオーム解析 / メタボローム解析 |
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| Research Abstract |
The role of immune cells function in pathogenesis of postoperative critical illness following major surgery was prospectively investigated. The mechanism of postoperative complications following hepato-biliary-pancreatic surgery is multifactorial. DAMPs play a major role in pathogenesis of organ dysfunction following liver resection, whereas postoperative infection depends on exocrine function of the pancreas in patients undergoing pancreatticoduodenectomy. P2X7 mRNA levels and T-bet/GATA-3 ratios in PBMC significantly decrease after major surgery in patients with postoperative infection, suggesting that high expression of P2X7 and Th1 have protective effects against bacterial infection in early postoperative period. TLRs mRNA levels in PBMC increased on day 3 and afterwards. These results suggest that DAMPs and PAMPs signals play a pivotal role in pathogenesis of postoperative complications following major surgery.
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