The effect of Rho Kinase inhibitor on the intimal hyperplasia induced by stenting
| Project/Area Number |
20591518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
YAMAMOTO Kiyohito Nagoya University, 医学部附属病院, 講師 (10298359)
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| Co-Investigator(Kenkyū-buntansha) |
KOMORI Kimihiro 名古屋大学, 大学院・医学系研究科, 教授 (40225587)
KOBAYASHI Masayoshi 名古屋大学, 医学部附属病院, 助教 (60329381)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | Rho-Kinase / ステント / 内膜肥厚 |
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| Research Abstract |
Background : Rho kinase plays an important role in vascular smooth muscle cell (VSMC) contraction and other cellular functions, such as proliferation, migration, and apoptosis. We examined whether long-term inhibition of Rho kinase suppresses stent-induced hyperplasia in hypercholesterolemic rabbits.
Experiment I :
Methods : Male rabbits were fed a 1.0% cholesterol diet for 4 weeks before stent implantation. Then, randomly divided into two groups and received cholesterol chow (control group) or a special chow containing fasudil.
Results : The intimal thickening of the fasudil group was comparable with the control group. There was not significant difference between the two groups.
Experiment II :
Background : We investigated whether Ezetimibe, which reduce the high-cholestetrol level, inhibited the intimal hyperplasia induced by vein graft and additionally, relationship between the inhibited effect on Rho-kinase.
Results : We demonstrated that oral administration of Ezetimibe to normocholesterolemic rabbits inhibited intimal hyperplasia of carotid interposition-reversed jugular vein grafts 4 weeks after implantation.
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Report
(4 results)
Research Products
(46 results)
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[Presentation] Sarpogrelate Hydrochloride Modulates the Expression of 5-Hydroxytryptamine Typo 2A and Type 1B Receptors in Experimental Rabbit Vein Grafts Arteriosclerosis2009
Author(s)
Kodama A, Tamai H, Idetsu A, Morimae H, Hori A, Narita H, Kobayashi M, Yamamoto K, Komori K
Organizer
Thrombosis and Vascular Biology Annual Conference 2009
Place of Presentation
Omni Shoreham Hotel, Washington, USA
Related Report
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[Presentation] 重症虚血肢における血管内治療の役割2008
Author(s)
山本清人, 出津明仁, 杉本昌之, 井原努, 新美清章, 児玉章朗, 成田裕司, 上遠野由紀, 小林昌義, 古森公浩
Organizer
第36回日本血管外科学会学術総会
Place of Presentation
アルカディア市ヶ谷デイア市ケ谷
Related Report
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