Effect of inducing neovascularization on islet transplantation
| Project/Area Number |
20591526
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TSUJIMURA Toshiaki Kobe University, 医学研究科, 医学研究員 (30403249)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Ippei 神戸大学, 医学部附属病院, 講師 (30379408)
SHINZEKI Makoto 神戸大学, 医学研究科, 助教 (60444593)
TOYAMA Hirochika 神戸大学, 医学部附属病院, 助教 (10444598)
GU Eisei 神戸大学, 医学研究科, 教授 (40195615)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 膵島移植 |
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| Research Abstract |
In the mouse islet transplant model with, neovascularisation around the transplanted islets was confirmed one week after transplant and was completed three weeks after transplant, The neovascularity increased by transplanting endothelial progenitor cells (EPC) jointly. By the pathological analysis using a GFP mouse, EPC remained in three weeks after transplant. Neovascularisation derived from EPC occurred in predominance around transplanted islets. However, by induction of EPC, the glucose tolerance of the diabetes mouse was not improved.
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Report
(4 results)
Research Products
(8 results)
