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Effect of inducing neovascularization on islet transplantation

Research Project

Project/Area Number 20591526
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKobe University

Principal Investigator

TSUJIMURA Toshiaki  Kobe University, 医学研究科, 医学研究員 (30403249)

Co-Investigator(Kenkyū-buntansha) MATSUMOTO Ippei  神戸大学, 医学部附属病院, 講師 (30379408)
SHINZEKI Makoto  神戸大学, 医学研究科, 助教 (60444593)
TOYAMA Hirochika  神戸大学, 医学部附属病院, 助教 (10444598)
GU Eisei  神戸大学, 医学研究科, 教授 (40195615)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵島移植
Research Abstract

In the mouse islet transplant model with, neovascularisation around the transplanted islets was confirmed one week after transplant and was completed three weeks after transplant, The neovascularity increased by transplanting endothelial progenitor cells (EPC) jointly. By the pathological analysis using a GFP mouse, EPC remained in three weeks after transplant. Neovascularisation derived from EPC occurred in predominance around transplanted islets. However, by induction of EPC, the glucose tolerance of the diabetes mouse was not improved.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (3 results)

  • [Journal Article] Effect of oxygenated perfluorocarbon on isolated islets during transportation2010

    • Author(s)
      Terai S, Tsujimura T, Toyama H, Shinzeki M, Matsumoto I, Kuroda Y, Ku Y.
    • Journal Title

      J Surg Res 162(2)

      Pages: 284-289

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Oxygenated Perfluorocarbon on Isolated Islets During Transportation2010

    • Author(s)
      Terai S, Tsujimura T, Toyama H, Shinzeki M, Matsumoto I, Kuroda Y, Ku Y.
    • Journal Title

      J Surg Res

      Volume: 162(2) Pages: 284-289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Oxygenated Perfluorocarbon on Isolated Islets During Transportation2009

    • Author(s)
      Terai S, Tsujimura T, Toyama H, Shinzeki M, Matsumoto I, Kuroda Y, Ku Y.
    • Journal Title

      J Surg Res (Epub ahead of print)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 膵臓及び膵島移植における保存法2008

    • Author(s)
      辻村敏明、黒田嘉和
    • Journal Title

      移植 第43巻・5号

      Pages: 351-356

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膵臓及び膵島移植における保存法2008

    • Author(s)
      辻村 敏明, 黒田 嘉和
    • Journal Title

      移植 第43巻・5号

      Pages: 351-356

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 拝島移植における膵島輸送方法の検討2008

    • Author(s)
      寺井祥雄, 辻村敏明, 具英成
    • Organizer
      第44回日本移植学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 膵島移植における膵島輸送方法の検討2008

    • Author(s)
      寺井祥雄, 辻村敏明, 李世日, 外山博近, 新関亮, 松本逸平, 黒田嘉和、具英成
    • Organizer
      日本移植学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 今後の展望膵臓移植vs膵島移植 神戸大学における膵島移植の現状と問題点2008

    • Author(s)
      谷岡康喜、酒井哲也、大河原弘達、辻村敏明、黒田嘉和
    • Organizer
      日本移植学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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