Inhibition of intimal hyperplasia by newly developed gene therapy utilizing nanobubble to control extracellular matrix
| Project/Area Number |
20591527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
ITO Hiroyuki Kyushu University, 大学病院, 特任講師 (10346778)
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| Co-Investigator(Kenkyū-buntansha) |
TERAMOTO Noriyoshi 佐賀大学, 医学部, 薬理学教授 (40294912)
松本 拓也 九州大学, 大学病院, 助教 (20374168)
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| Co-Investigator(Renkei-kenkyūsha) |
INOGUCHI Hiroyuki 九州大学, 大学病院, 医員 (20432940)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 血行再建 / 新生内膜肥厚 / 血管平滑筋細胞 / 細胞外基質 / sonoporation / 遺伝子治療 / ナノバブル / 血管平滑筋 / 内膜肥厚 / ナノバプル / 血管外科 |
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| Research Abstract |
(1) Successful gene transfection in desired cells by sonoporation technique
(2) Successful ex-vivo gene transfection into mouse aortic tissue by sonoporation technique
(3) Inhibition of intimal hyperplasia by adiponectin and eplerenon which has an inihibitory effect for ECM production
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] The efficacy of oral beraprost sodium, a prostaglandin I2 analogue, for treating intermittent claudication in patients with arteriosclerosis obliterans.2010
Author(s)
Matsumoto T, Iwasa K, Kyuragi R, Honma K, Guntani A, Ohmine T, Itoh H, Onohara T, Maehara Y
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Journal Title
Int Angiol. Apr;29(2 Suppl)
Pages: 49-54
Related Report
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