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Inhibition of intimal hyperplasia by newly developed gene therapy utilizing nanobubble to control extracellular matrix

Research Project

Project/Area Number 20591527
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionKyushu University

Principal Investigator

ITO Hiroyuki  Kyushu University, 大学病院, 特任講師 (10346778)

Co-Investigator(Kenkyū-buntansha) TERAMOTO Noriyoshi  佐賀大学, 医学部, 薬理学教授 (40294912)
松本 拓也  九州大学, 大学病院, 助教 (20374168)
Co-Investigator(Renkei-kenkyūsha) INOGUCHI Hiroyuki  九州大学, 大学病院, 医員 (20432940)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords血行再建 / 新生内膜肥厚 / 血管平滑筋細胞 / 細胞外基質 / sonoporation / 遺伝子治療 / ナノバブル / 血管平滑筋 / 内膜肥厚 / ナノバプル / 血管外科
Research Abstract

(1) Successful gene transfection in desired cells by sonoporation technique
(2) Successful ex-vivo gene transfection into mouse aortic tissue by sonoporation technique
(3) Inhibition of intimal hyperplasia by adiponectin and eplerenon which has an inihibitory effect for ECM production

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 Other

All Journal Article (5 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] The efficacy of oral beraprost sodium, a prostaglandin I2 analogue, for treating intermittent claudication in patients with arteriosclerosis obliterans.2010

    • Author(s)
      Matsumoto T, Iwasa K, Kyuragi R, Honma K, Guntani A, Ohmine T, Itoh H, Onohara T, Maehara Y
    • Journal Title

      Int Angiol. Apr;29(2 Suppl)

      Pages: 49-54

    • Related Report
      2010 Final Research Report
  • [Journal Article] 慢性重症虚血肢に対するFGF2遺伝子搭載センダイウイルスベクターを用いた新規血管新生遺伝子治療臨床研究:中間報告2010

    • Author(s)
      伊東啓行、米満吉和、井口博之、福永亮大、高井真紀、岩佐憲臣、本間健一、吉田久美、居石克夫、前原喜彦
    • Journal Title

      脈管学 50

      Pages: 309-314

    • NAID

      10026912153

    • Related Report
      2010 Final Research Report
  • [Journal Article] 多発性内臓動脈瘤に対する1手術例2010

    • Author(s)
      諸富洋介、伊東啓行、井口博之、内山秀昭、米満吉和、前原喜彦
    • Journal Title

      日本血管外科学会雑誌 19

      Pages: 17-21

    • NAID

      10026408615

    • Related Report
      2010 Final Research Report
  • [Journal Article] 重症虚血肢に対する血管新生遺伝子療法の現況と問題点2009

    • Author(s)
      伊東啓行、米満吉和、井口博之、福永亮大、松本拓也、前原喜彦
    • Journal Title

      血管外科 28(1)

      Pages: 21-26

    • Related Report
      2010 Final Research Report
  • [Journal Article] 総大腿動脈外膜嚢腫の1例2009

    • Author(s)
      間野洋平、福永亮大、伊東啓行、本間健一、井口博之、前原喜彦
    • Journal Title

      日本血管外科学会雑誌 18

      Pages: 673-676

    • NAID

      10026114074

    • Related Report
      2010 Final Research Report
  • [Presentation] 慢性重症虚血肢に対するFGF2遺伝子搭載センダイウイルスベクターを用いた革新的血管新生遺伝子治療臨床研究:第2報2009

    • Author(s)
      伊東啓行、米満吉和、井口博之、福永亮大、吉田久美、居石克夫、前原喜彦
    • Organizer
      第109回日本外科学会定期学術集会シンポジウム(1)外科領域における遺伝子治療・再生医療の問題点と今後の展開
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-02
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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