Development of novel cancer diagnosis and treatment targeting splicing variants of c-myc transcriptional suppressor FIR

• Project/Area Number: 20591543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Chiba University
• Principal Investigator: MATSUSHITA Kazuyuki Chiba University, 大学院・医学研究院, 講師 (90344994)
• Co-Investigator(Kenkyū-buntansha): 朝長 毅 千葉大学, 大学院・医学研究院, 准教授 (80227644) ; 星野 忠次 千葉大学, 大学院・医学研究院, 准教授 (90257220) ; 田村 裕 千葉大学, 大学院・医学研究院, 准教授 (50263174) ; 野村 文夫 千葉大学, 大学院・医学研究院, 教授 (80164739)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 癌遺伝子治療 / c-myc遺伝子 / 癌診断 / 癌治療 / スプライシング阻害薬 / SF3b155 / 転写制御因子 / アポトーシス

Research Abstract

Far UpStream Element (FUSE)-binding protein-interacting repressor (FIR), a c-myc transcriptional suppressor, is alternatively spliced and futilely produced in colorectal cancer tissues that abundantly express c-Myc. Human malignant pleural mesothelioma (HMPM) is highly resistant to conventional therapy, and novel therapies are thus required. We previously reported that overexpression of FIR induces apoptosis via c-Myc suppression, and is thus a suitable cancer therapy. In the current preclinical trial, a fusion gene deleted non-transmissible Sendai virus vector encoding FIR (SeV/ΔF/FIR) was prepared and its cytotoxic activity against an orthotopic xenograft model of HMPM, in combination with cisplatin, was assessed. SeV/ΔF/FIR significantly reduced cell viability in 3 HMPM cell lines but was less effective in non-tumor immortalized mesothelial cells. SeV/ΔF/FIR cytotoxicity was partly due to apoptosis induction via c-Myc supression.

Research Products

• [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in treatment of malignant pleural mesothelioma. (2011)
  • Author(s): Kitamura A, Matsushita K, Takiguchi Y, Shimada Hideaki, Tomonaga T, Matsubara H. Inou, M, Mamoru H, Sato Y, Levens D, Tatsumi K, Nomura F.
  • Journal Title: Cancer Science. in press
  • NAID: 10029295478
• [Journal Article] An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer. (2011)
  • Author(s): Wu D, Matsushita K, Matsubara H, Nomura F, Tomonaga T.
  • Journal Title: Int J Cancer. 128(5) Pages: 1018-1030
• [Journal Article] Decreases in the Serum VLDL-TG/Non-VLDL-TG Ratio from Early Stages of Chronic Hepatitis C : Alterations in TG-Rich Lipoprotein Levels. (2011)
  • Author(s): Nishimura M, Yamamoto H, Yoshida T, Seimiya M, Sawabe Y, Matsushita K, Umemura H, Sogawa K, Takizawa H, Yokosuka O, Nomura F.
  • Journal Title: PLoS ONE Research Article published 25
• [Journal Article] Synergistic effect of non-transmissible Sendai virus vector encoding the c-myc suppressor FUSE-binding protein-interacting repressor plus cisplatin in treatment of malignant pleural mesothelioma. (2011)
  • Author(s): Kitamura A, Matsushita K, Takiguchi Y, Shimada Hideaki, Tomonaga T, Matsubara H.Inou, M, Mamoru H, Sato Y, Levens D, Tatsumi K, Nomura F.
  • Journal Title: Cancer Science Volume: In press
  • NAID: 10029295478
  • Peer Reviewed
• [Journal Article] Decreases in -the serum VLDL-TG/non-VLDL-TG ratiofrom early stages of chronic hepatitis C: Alterationsin TG-rich lipoprotein levels. (2011)
  • Author(s): Nishimura M, Yamamoto H, Yoshida T, Seimiya M, Sawabe Y, Matsushita K, Umemura H, Sogawa K, Takizawa H, Yokosuka O, Nomura F.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed
• [Journal Article] Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis. (2011)
  • Author(s): Umemura H, Togawa A, Sogawa K, Satoh M, Mogushi K, Nishimura M, Matsushita K, Tanaka H, Takizawa H, Kodera Y, Nomura F.
  • Journal Title: J Gastroenterol. Volume: In press
  • NAID: 10029028943
  • Peer Reviewed
• [Journal Article] Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer. (2010)
  • Author(s): Kawahira H, Matsushita K, Shiratori T, Shimizu T, Nabeya Y, Hayashi H, Ochiai T, Matsubara H, Shimada H.
  • Journal Title: Cancer Science. 101(1) Pages: 289-291
  • NAID: 10027200634
• [Journal Article] CHAP31 Induces Apoptosis Only via the Intrinsic Pathway in Human Esophageal Cancer Cells. (2010)
  • Author(s): Murakami K, Matsubara H, Hoshino I, Akutsu Y, Miyazawa Y, Matsushita K, Sakata H, Nishimori T, Usui A, Kano M, Nishino N, Yoshida M.
  • Journal Title: Oncology. 78(1) Pages: 62-74
• [Journal Article] Phosphorylation statuses at different residues of lamin B2, B1, and A/C dynamically and independently change throughout the cell cycle. (2010)
  • Author(s): Kuga T, Nozaki N, Matsushita K, Nomura F, Tomonaga T.
  • Journal Title: Exp Cell Res. 316(14) Pages: 2301-2312
• [Journal Article] Reducing the incidence of pseudohyperkalemia by avoiding making a fist during phlebotomy : a quality improvement report. (2010)
  • Author(s): Seimiya M, Yoshida T, Sawabe Y, Sogawa K, Umemura H, Matsushita K, Nomura F.
  • Journal Title: Am J Kidney Dis. 56(4) Pages: 686-692
• [Journal Article] Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age. (2010)
  • Author(s): Ritchie SA, Heath D, Yamazaki Y, Grimmalt B, Kavianpour A, Krenitsky K, Elshoni H, Takemasa I, Miyake M, Sekimoto M, Monden M, Tomonaga T, Matsubara H, Sogawa K, Matsushita K, Nomura F, Goodenowe DB.
  • Journal Title: BMC Gastroenterology 10 Pages: 140-140
• [Journal Article] Angiogenesis-related factors are molecular targets for diagnosis and treatment of patients with esophageal carcinoma.Review. (2010)
  • Author(s): Oshima Y, Yajima S, Yamazaki K, Matsushita K, Tagawa M, Shiomada H.
  • Journal Title: Ann Thorac Cardiovasc Surg 16(6) Pages: 389-393
• [Journal Article] Angiogenesis-related factors are molecular targets for diagnosis and treatment of patients with esophageal carcinoma.Review. (2010)
  • Author(s): Oshima Y, Yajima S, Yamazaki K, Matsushita K, Tagawa M, Shiomada H.
  • Journal Title: Ann .Thorac Cardiovasc Surg Volume: 16 Pages: 389-393
  • Peer Reviewed
• [Journal Article] Reduction of novel circulating long-chain fatty acids in colorectal cancer patients is independent of tumor burden and correlates with age. (2010)
  • Author(s): Ritchie SA, Heath D, YamazakiY, Grimmalt B, Kavianpour A, Krenitsky K, Elshoni H, Takemasa I, Miyake M, Sekimoto M, Monden M, Tomonaga T, Matsubara H, Sogawa K, Matsushita K, Nomura F, Goodenowe DB.
  • Journal Title: BMC Gastroenterology Volume: 10 Pages: 140-148
  • Peer Reviewed
• [Journal Article] Pseudohyperkalemia caused by making a fist duringphlebotomy -Prevalence before and after taking appropriate preventive measures. (2010)
  • Author(s): Seimiya M, Yoshida T, Sawabe Y, Umemura H, Matsushita K, Nomura.F.
  • Journal Title: American J Kidney Dis Volume: 56 Pages: 686-692
  • Peer Reviewed
• [Journal Article] Phosphorylation statuses at different residues of lamin B2, B1, and A/Cdynamically and independently change throughout the cell cycle. (2010)
  • Author(s): Kuga T, Nozaki N, Matsushita K, Nomura F , Tomonaga T..
  • Journal Title: Exp Cell Res. Volume: 316 Pages: 2301-12
  • Peer Reviewed
• [Journal Article] CHAP31 Induces Apoptosis Only via the Intrin sicPathway in Human Esophageal Cancer Cells. (2010)
  • Author(s): Murakami K, Matsubara H, Hoshino I, Akutsu Y, Miyazawa Y, Matsushita K, Sakata H, Nishimori T, Usui A, Kano M, Nishino N, Yoshida M.
  • Journal Title: Oncology. 78(1) Pages: 62-74
  • Peer Reviewed
• [Journal Article] Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer. (2010)
  • Author(s): Kawahira H, Matsushita K, Shiratori T, Shimizu T, Nabeya Y, Hayashi H, Ochiai T, Matsubara H, Shimada H.
  • Journal Title: Cancer Science 101(1) Pages: 289-91
  • NAID: 10027200634
  • Peer Reviewed
• [Journal Article] Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma. (2009)
  • Author(s): Shimada H, Shiratori T, Takeda A, Matsushita K, Okazumi S, Akutsu Y, Matsubara H, Nomura F, Ochiai T.
  • Journal Title: World J Surg. 33(2) Pages: 272-277
• [Journal Article] Nomura F c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy. (2009)
  • Author(s): Matsushita K, Tomonaga T, Kajiwara T, Shimada H, Itoga S, Hiwasa T, Kubo S, Ochiai T, Matsubara H
  • Journal Title: Frontiers in Bioscience 14 Pages: 3401-3408
• [Journal Article] YKL-40 identified by proteomic analysis as a biomarker of sepsis. (2009)
  • Author(s): Hattori N, Oda S, Sadahiro T, Nakamura M, Abe R, Shinozaki K, Nomura F, Tomonaga T, Matsushita K, Kodera Y, Sogawa K, Satoh M, Hirasawa H.
  • Journal Title: Shock. 32(4) Pages: 393-400
• [Journal Article] YKL-40 indentified by proteomic analysis as a biomarker of sepsis (2009)
  • Author(s): Hattori N, Oda S, Sadahiro T, Nakamura M, Abe R, Shinozaki K, Nomura F, Tomonaga T, Matsushita K, Kodera Y, Sogawa K, Satoh M, Hirasawa H.
  • Journal Title: Shock. 32(4) Pages: 393-400
  • Peer Reviewed
• [Journal Article] c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy (2009)
  • Author(s): Matsushita K, Tomonaga T, Kajiwara T, Shimada H, Itoga S, Hiwasa T, Kubo S, Ochiai T, Matsubara H, Nomura F
  • Journal Title: Frontiers in Bioscience 14 Pages: 3401-3408
  • Peer Reviewed
• [Journal Article] Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma. (2009)
  • Author(s): Shimada H, Shiratori T, Takeda A, Matsushita K, Okazumi S, Akutsu Y, Matsubara H, Nomura F, Ochiai T
  • Journal Title: World J Surg. 33(2) Pages: 272-277
  • Peer Reviewed
• [Journal Article] c-myc suppressor FBP-interacting repressor for cancer diagnosis and therapy (2009)
  • Author(s): Matsushita K, Tomonaga T, Kajiwara T, Shimada H, Itoga S, Hiwasa T, Kubo S, Ochiai T, Matsubara H, Nomura F
  • Journal Title: Frontiers in Bioscienc 14 Pages: 3401-3408
  • Peer Reviewed
• [Journal Article] YKL-40 identified by proteomic analysis as a biomarker of sepsis (2009)
  • Author(s): Hattori N, Oda S, Sadahiro T, Nakamura M, Abe R, Shinozaki K, Nomura F, Tomonaga T, Matsushita K, Kodera Y, Sogawa K, Satoh M, Hirasawa H
  • Journal Title: Shock. (In press)
  • Peer Reviewed
• [Journal Article] 遺伝子研究と倫理遺伝子検査、遺伝子診断、遺伝子治療、再生医療から遺伝子ビジネスへ (2009)
  • Author(s): 松下一之、朝長毅、西村基、宇津野恵、梅村啓史、野村文夫
  • Journal Title: 医療と検査機器・試薬 (In press)
  • Peer Reviewed
• [Journal Article] がんの早期診断に役立つ遺伝子診断マーカーの開発 (2009)
  • Author(s): 松下一之,梶原寿子,糸賀栄,朝長毅,小寺義男,野村文夫
  • Journal Title: 月刊「化学工業」 (In press)
  • Peer Reviewed
• [Journal Article] Role of histone deacetylase inhibitor in adenovirus-mediated p53 gene therapy in esophageal cancer. (2008)
  • Author(s): Hoshino I, Matsubara H, Akutsu Y, Nishimori T, Yoneyama Y, Murakami K, Sakata H, Matsushita K, Komatsu A, Brooks R, Ochiai T
  • Journal Title: Anticancer Res. 28(2A) Pages: 665-671
  • Peer Reviewed
• [Journal Article] Combined Effects of p53 Gene Therapy and Leptomycin B in Human Esophageal Squamous Cell Carcinoma. (2008)
  • Author(s): Hoshino I, Matsubara H, Komatsu A, Akutsu Y, Nishimori T, Yoneyama Y, Murakami k, Sakata H, Matsushita K, Miyazawa Y, Brooks R, Yoshida M, Ochiai T.
  • Journal Title: Oncology. 75(1-2) Pages: 113-119
  • Peer Reviewed
• [Presentation] シスタチンCを中心とした腎機能マーカーと尿沈渣円柱の関連性について (2010)
  • Author(s): 伊瀬恵子、内本高之、澤部祐司、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] 酵素活性測定用JSCC標準化対応法の性能比較は必要か? (2010)
  • Author(s): 清宮正徳、吉田俊彦、澤部祐司、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] 遺伝性大腸癌関連遺伝子(APC, MLH 1, MSH2, MSH6)のHRM(High R, esoluthion Melting)解析によるGene Scanning (2010)
  • Author(s): ジュレトウブリ、糸賀栄、佐藤謙一、石毛崇之、宇津野恵美、澤部祐司、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] 腫瘍組織検体のHigh Resolution Melting(HRM)による高感度なEGFR, KRAS, BRAF遺伝子変異スクリーニング (2010)
  • Author(s): 佐藤謙一、糸賀栄、石毛崇之、松下一之、澤部祐司、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] HPVタイピング検査「クリニチップHPV」の既存HPV-DNA検出キットとの比較による臨床的有用性の評価 (2010)
  • Author(s): 佐藤亮、糸賀栄、小杉玲子、小池優、吉田博、澤部祐司、松下一之、三橋暁、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] MALDI Bio TyperTMを用いたプロテオミクスによる微生物迅速同定法の評価 (2010)
  • Author(s): 曽川一幸、渡邊正治、梅村啓史、瀬川俊介、石井知里、宮部安規子、村田正太、斎藤知子、佐藤守、澤井摂、西村基、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-09
• [Presentation] アーキテクトを用いたHCVコア抗原測定の検討 (2010)
  • Author(s): 子安未緒、清宮正徳、吉田俊彦、佐藤謙一、糸賀栄、澤部祐司、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-08
• [Presentation] 小型臨床化学検査装置BBxの検討 (2010)
  • Author(s): 清宮正徳、吉田俊彦、澤部祐司、松下一之、野村文夫
  • Organizer: 日本臨床検査自動化学会42回大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-10-08
• [Presentation] 血清プロテオミクスによる早期胃癌診断マーカーの同定 (2010)
  • Author(s): 梅村啓史、外川明、曽川一幸、茂櫛薫、西村基、松下一之、小寺義男、野村文夫
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-02
• [Presentation] ガンにおける選択的スプライシングの意義と遺伝子診療への応用 (2010)
  • Author(s): 松下一之、梶原寿子、糸賀栄、佐藤守、西村基、梅村啓史、澤井摂、ウーディー、朝長毅、小寺義男、野村文夫
  • Organizer: 第17回日本遺伝子診療学会
  • Place of Presentation: 三重
  • Year and Date: 2010-08-07
• [Presentation] HRM(High Resolution Melting)法を用いた遺伝性大腸癌の遺伝子変異スクリーニング (2010)
  • Author(s): 糸賀栄、ジュレトウブリ、佐藤謙一、石毛宗之、宇津野恵美、松下一之、野村文夫
  • Organizer: 第17回日本遺伝子診療学会
  • Place of Presentation: 三重
  • Year and Date: 2010-08-07
• [Presentation] 千葉大学院遺伝子診療部における脊髄小脳変性症の遺伝カウンセリング(記録と遺伝学的検査結果の検討) (2010)
  • Author(s): 宇津野恵美、澤井摂、糸賀栄、佐藤謙一、梅村啓史、西村基、松下一之、野村文夫
  • Organizer: 第17回日本遺伝子診療学会
  • Place of Presentation: 三重
  • Year and Date: 2010-08-07
• [Presentation] 遺伝性神経筋疾患の発祥前診断における遺伝カウンセリング(千葉大病院における20例の検討) (2010)
  • Author(s): 澤井摂、宇津野恵美、梅村啓史、西村基、松下一之、金井数明、桑原聡、羽田明、野村文夫
  • Organizer: 第17回日本遺伝子診療学会
  • Place of Presentation: 三重
  • Year and Date: 2010-08-07
• [Presentation] c-myc遺伝子転写抑制因子FIRのsplicing variantを標的とした癌診断法・癌治療法の開発 (2009)
  • Author(s): 松下一之、朝長毅、梶原寿子、島田英昭、野村文夫
  • Organizer: 日本分子生物学会・日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-12-12
• [Presentation] c-myc遺伝子転写抑制因子FIRのsplicing variantを標的とした癌診断法・癌治療法の開発 (2009)
  • Author(s): 松下一之、朝長毅、糸賀栄、曽川一幸、梶原寿子、梅村啓史、西村基、野村文夫
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-28
• [Presentation] c-myc遺伝子転写抑制因子FBP-binding protein(FIR)による癌遺伝子治療の開発 (2009)
  • Author(s): 松下一之、朝長毅、島田英昭、梶原寿子、問宮俊太、松原久裕、山田滋、加野将之、野村文夫
  • Organizer: 第66回日本消化器外科学会定期学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-28
• [Presentation] c-myc遺伝子転写抑制因子FIRの癌特異的スプライシングバリアントを標的とした癌診断法および癌治療薬の開発 (2009)
  • Author(s): 松下一之、梶原寿子、朝長毅、島田英昭、田村裕、星野忠治、野村文夫
  • Organizer: 第27回日本分子腫瘍マーカー研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-02
• [Presentation] 国産技術と特許を有するc-myc遺伝子転写抑制因子FIRを用いた癌遺伝子治療の開発 (2009)
  • Author(s): 松下一之、朝長毅、島田英昭、松原久裕、野村文夫
  • Organizer: 第63回日本消化器外科学会定期学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2009-07-17
• [Presentation] 細胞質型RNAセンダイウイルスベクターにc-myc遺伝子転写抑制因子を搭載した癌遺伝子治療法の開発 (2009)
  • Author(s): 松下一之, 朝長毅, 島田英昭, 米満吉和, 上田泰次, 落合武徳, 松原久裕, 野村文夫
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-04
• [Presentation] c-myc遺伝子転写抑制因子FIRのsplicing variantを標的とした癌診断法・癌治療法の開発. (2008)
  • Author(s): 松下一之,朝長毅,梶原寿子,風見隆浩,久家貴寿,野村文夫
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] c-myc遺伝子転写抑制因子FIRのsplicing variantを標的とした癌診断法・癌治療法の開発. (2008)
  • Author(s): 松下一之,朝長毅,梶原寿子,風見隆浩,久家貴寿,野村文夫
  • Organizer: 第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-11
• [Presentation] c-myc遺伝子転写抑制因子FIRを分子標的とした癌治療法・診断法の開発 (2008)
  • Author(s): 松下一之,朝長毅,梶原寿子,糸賀栄,野村文夫
  • Organizer: 第1180回千葉医学会例会
  • Place of Presentation: 千葉
  • Year and Date: 2008-12-07
• [Presentation] c-myc遺伝子転写抑制因子FIRのsplicing variantを標的とした癌治療法・診断法の開発 (2008)
  • Author(s): 松下一之,朝長毅,糸賀栄,曽川一幸,梶原寿子,梅村啓史,西村基,野村文夫
  • Organizer: 第55回日本臨床検査医学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-11-28
• [Presentation] c-myc遺伝子転写抑制因子FIRを搭載した国産センダイウイルスベクターによる癌遺伝子治療法の開発 (2008)
  • Author(s): 松下一之,朝長毅,島田英昭,梶原寿子,松原久裕,田村裕,野村文夫
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-29
• [Remarks] ホームページ等
• [Remarks] 千葉大学大学院医学研究院分子病態解析学
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学大学院医学研究院先端応用外科学
  • URL: http://www.academic-surgery.jp/
• [Remarks] 千葉大学大学院医学研究院分子病態解析学
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学大学院医学研究院先端応用外科学
  • URL: http://www.academic-surgery.jp/
• [Remarks] 千葉大学大学院医学研究院分子病態解析学
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学大学院医学研究院先端応用外科学
  • URL: http://www.academic-surgery.jp/
• [Remarks] 千葉大学大学院医学研究院分子病態解析学
  • URL: http://www.m.chiba-u.ac.jp/class/moldiag/
• [Remarks] 千葉大学大学院医学研究院先端応用外科学
  • URL: http://www.academic-surgery.jp
• [Patent(Industrial Property Rights)] 癌に特異的な遺伝子及びそれを用いた診断キット (2011)
  • Inventor(s): 島田英昭、朝長毅、松下一之、落合武徳、野村文夫
  • Industrial Property Rights Holder: 国立大学法人千葉大学
  • Acquisition Date: 2011-02-10
• [Patent(Industrial Property Rights)] 腫瘍マーカー及びそれを用いた診断キット (2011)
  • Inventor(s): 島田英昭、朝長毅、松下一之、落合武徳、野村文夫、車英俊、松本和将
  • Industrial Property Rights Holder: 国立大学法人千葉大学
  • Acquisition Date: 2011-01-14
• [Patent(Industrial Property Rights)] アポトーシス誘導剤及びアポトーシス誘導方法 (2010)
  • Inventor(s): 松下一之・島田英昭・朝長毅・野村文夫・落合武徳
  • Industrial Property Rights Holder: 千葉大学
  • Acquisition Date: 2010