Development of new treatment of sepsis with adiponectin

• Project/Area Number: 20591544
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Shiga University of Medical Science
• Principal Investigator: YAMAMOTO Hiroshi Shiga University of Medical Science, 医学部, 助教 (00283557)
• Co-Investigator(Renkei-kenkyūsha): TANI Tohru 滋賀医科大学, 医学部, 教授 (20179823) ; MAEDA Kazuhisa 大阪大学, 医学系研究科, 助教 (60397750)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 外科 / 感染症 / 生理活性 / 臨床 / アディポネクチン / 感染予測 / エンドトキシン / 胃癌 / adiponectin / sepsis / cytokine / hepatic injury / 敗血症 / KOマウス / PPARγ

Research Abstract

The role of adiponectin in sepsis has been revealed by using adiponectin KO mouse. In the clinical study, adiponectin ratio has been shown to be an useful marker to predict the postoperative infection.

Research Products

• [Journal Article] Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis (2010)
  • Author(s): Uji Yoshitaka, Yamamoto Hiroshi, Maeda Kazuhisa, Tsuchihashi Hiroshi, Akabori Hiroya, Shimizu Tomoharu, Endo Yoshihiro, Shimomura Iichiro, Tani Tohru
  • Journal Title: Journal of Surgical Research 161 Pages: 301-311
  • Peer Reviewed
• [Journal Article] diponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis (2010)
  • Author(s): Uji Yoshitaka, Yamamoto Hiroshi, et al.
  • Journal Title: Journal of Surgical Research Volume: 161 Pages: 301-311
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency is associated with severe polymicrobial sepsis high inflammatory cytokine levels, and high mortality (2009)
  • Author(s): Uji Yoshitaka, Yamamoto Hiroshi, Tsuchihashi Hiroshi, Maeda Kazuhisa, Funahashi Tohru, Shimomura Iichirou, Shimizu Tomoharu, Endo Yoshihiro, Tani Tohru
  • Journal Title: Surgery 145(5) Pages: 550-557
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency promotes the production of- (2009)
  • Author(s): Uji Y, Yamamoto H, et al.
  • Journal Title: J Surg Res Jan14(Epub)
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency is associated with- (2009)
  • Author(s): Uji Y, Yamamoto H, et al.
  • Journal Title: Surgery 145 Pages: 550-7
  • Peer Reviewed
• [Journal Article] 敗血症における adiponectin の役割について (2009)
  • Author(s): 宇治祥隆, 山本寛, ほか
  • Journal Title: 日本ショック学会雑誌 24(2) Pages: 60-64
  • Peer Reviewed
• [Journal Article] アディポネクチンと術後感染の関係は? (2009)
  • Author(s): 山本寛
  • Journal Title: 肥満と糖尿病 8(4) Pages: 503-5
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis. (2009)
  • Author(s): Yoshitaka Uji, Hiroshi Yamamoto, et al.
  • Journal Title: Journal of Surgcal Research (in press)
  • Peer Reviewed
• [Journal Article] Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality. (2009)
  • Author(s): Yoshitaka Uji, Hiroshi Yamamoto, et al.
  • Journal Title: Surgery (in press)
  • Peer Reviewed
• [Journal Article] 腹部外科手術の周術期における血中アディポネクチンの測定意義について (2008)
  • Author(s): 山本寛, 前田和久, 下村伊一郎, 谷徹
  • Journal Title: 肥満研究 14(2) Pages: 174-179
  • NAID: 10026149567
  • Peer Reviewed
• [Presentation] 消化器外科手術における血中エンドトキシンの評価 (2011)
  • Author(s): 清水智治, 赤堀浩也, 山本寛, 遠藤善裕, 小幡徹, 谷徹
  • Organizer: 第3回高感度エンドトキシン測定ESPテクニカルセミナー・シンポジウム
• [Presentation] 大腸癌手術における周術期感染制御-ESP法による血中エンドトキシン測定の意義- (2010)
  • Author(s): 清水智治, 山本寛, 目片英治, 龍田健, 村田聡, 赤堀浩也, 小幡徹, 遠藤善裕, 来見良誠, 谷徹
  • Organizer: 第23回日本外科感染学会総会
  • Place of Presentation: (特別企画)
• [Presentation] 腹部外科手術の術後感染予測指標としてのアディポネクチンの測定意義について (2010)
  • Author(s): 山本寛, 前田和久, 赤堀浩也, 森毅, 山口剛, 清水智治, 村田聡, 門田文, 三浦克之, 谷徹
  • Organizer: 第31回日本肥満学会
• [Presentation] 敗血症患者におけるESP 法による血中エンドトキシンの評価 (2010)
  • Author(s): 清水智治, 赤堀浩也, 三宅亨, 村田聡, 山本寛, 小幡徹, 遠藤善裕, 谷徹
  • Organizer: 第16回日本エンドトキシン・自然免疫研究会・シンポジウム
• [Presentation] 敗血症患者におけるESP法による血中エンドトキシンの評価 (2010)
  • Author(s): 清水智治, 赤堀浩也, 三宅亨, 村田聡, 山本寛, 小幡徹, 遠藤善裕, 谷徹
  • Organizer: 第16回日本エンドドキシン・自然免疫研究会
  • Place of Presentation: 奈良
• [Presentation] 大腸癌手術における周術期感染制御-ESP法による血中エンドトキシン測定の意義- (2010)
  • Author(s): 清水智治, 山本寛, 目片英治, 龍田健, 村田聡, 赤堀浩也, 小幡徹, 遠藤善裕, 来見良誠, 谷徹
  • Organizer: 第23回日本外科感染症学会総会(特別企画)
  • Place of Presentation: 東京
• [Presentation] 腹部外科手術の術後感染予測指標としてのアディポネクチンの測定意義について (2010)
  • Author(s): 山本寛, 前田和久, 赤堀浩也, 森毅, 山口剛, 清水智治, 村田聡, 門田文, 三浦克之谷徹
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 群馬
• [Presentation] Reduction of plasma adiponectin levels and risk of- (2009)
  • Author(s): Yamamoto H, et al
  • Organizer: DDW
  • Place of Presentation: USA (Chicago)
  • Year and Date: 2009-06-01
• [Presentation] Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis (2009)
  • Author(s): Hiroshi Yamamoto, et al.
  • Organizer: APFHPBA 2009
  • Place of Presentation: タイ(バンコク)
  • Year and Date: 2009-03-26
• [Presentation] Adiponectin deficiency promotes the production of inflammatory mediators while severely exacerbating hepatic injury in mice with polymicrobial sepsis (2009)
  • Author(s): Yamamoto Hiroshi, Maeda Kazuhisa, Uji Yoshitaka, Shimomura Iichiro, Tani Tohru
  • Organizer: 2nd Biennial Congress of the Asian-Pacfic Hepato-Pancreato-Biliary Association (APHPBA 2009)
• [Presentation] Reduction of plasma adiponectin levels and risk of bacterial infection after major abdominal surgery (2009)
  • Author(s): Yamamoto Hiroshi, Maeda Kazuhisa, Uji Yoshitaka, Shimizu Tomoharu, Tani Tohru
  • Organizer: Digestive Desease Week 2009(DDW2009)
• [Presentation] Reduction of plasma adiponectin levels and risk of bacterial infection after major abdominal surgery (2009)
  • Author(s): Maeda Kazuhisa, Yamamoto Hiroshi, Uji Yoshitaka, Shimomura Iichiro, Tani Tohru
  • Organizer: 2nd Biennial Congress of the Asian-Pacfic Hepato-Pancreato-Biliary Association (APHPBA 2009)
• [Presentation] 消化器外科周術期の血中微生物構成成分の変動 (2009)
  • Author(s): 清水智治, 遠藤善裕, 目片英治, 山本寛, 村田聡, 塩見尚礼, 仲成幸, 森毅, 赤堀浩也, 田畑貴久, 山口剛, 来見良誠, 谷徹
  • Organizer: 第34回日本外科系連合学会学術集会・ワークショップ
• [Presentation] 敗血症におけるAdiponectin の役割について-Adiponectin 欠損マウス敗血症モデルを用いて- (2009)
  • Author(s): 宇治祥隆, 山本寛, 土橋洋史, 赤堀浩也, 森毅, 清水智治, 遠藤善裕, 谷徹
  • Organizer: 第24回日本Shock学会
  • Place of Presentation: (会長賞選考講演(基礎部門))
• [Presentation] 大腸癌手術でのプロカルシトニンテストをガイドとした術後予防的抗菌薬の投与方法の検討 (2009)
  • Author(s): 生田大二, 清水智治, 龍田健, 目片英治, 塩見尚礼, 遠藤善裕, 山本寛, 村田聡, 来見良誠, 谷徹
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: (要望演題)
• [Presentation] Adiponectin deficiency exacerbates the concentration of plasma endotoxion and the production of inflammatory mediators in mice with polymicrobial sepsis (2008)
  • Author(s): Uji Yoshitaka, Yamamoto Hiroshi, Tsuchihashi Hiroshi, Akabori Hiroya, Shimizu Tomoharu, EndoYoshihiro, Tani Tohru
  • Organizer: The 10th Biennial Meeting of the International Endotoxin and Innate Immunity Society(IEIIS)
• [Book] 肥満と糖尿病(特集/感染症-予防と治療の実際Q, A 肥満アディポネクチンと術後感染の関係は?外科手術におけるアディポネクチン測定と術後感染の関係について教えて下さい)(8(4)) (2009)
  • Author(s): 山本寛
• [Remarks] ホームページ等
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [Remarks]
  • URL: http://www.shiga-med.ac.jp/db/index.php
• [Patent(Industrial Property Rights)] 侵襲管理方法及びアデイポネクチンの利用 (2005)
  • Inventor(s): 前田和久、山本寛
  • Industrial Property Rights Holder: 前田和久、山本寛
  • Filing Date: 2005-03-31