The Y-box binding protein-1 (YB-1) functions in various biological processes, including transcriptional and translational control, DNA repair, drug resistance, and cell proliferation in gastrointestinal malignancies.
| Project/Area Number |
20591548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KAKEJI Yoshihiro Kyushu University, 医学研究院, 准教授 (80284488)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Masaru 九州大学, 大学病院, 講師 (30294937)
SADANAGA Noriaki 九州大学, 医学研究院, 非常勤講師 (20304826)
SAEKI Hiroshi 九州大学, 大学病院, 助教 (80325448)
OHGA Takefumi 九州大学, 大学病院, 助教 (60335958)
SONODA Hideto 九州大学, 医学研究院, 学術研究員 (00465725)
EGASHIRA Akinori 九州大学, 医学研究院, 客員助教 (00419524)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 抗癌剤耐性 / DNA修復 / YB-1 / 胃癌 / 食道癌 |
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| Research Abstract |
The eukaryotic Y-box binding protein-1 (YB-1) functions in various biological processes, includingtranscriptional and translational control, DNA repair, drug resistance, and cell proliferation. YB-1+/cells showed increased sensitivity to cisplatin and mitomycin C, but not to etoposide, X-ray or UV irradiation, as compared to YB-1+/+cells. YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance.
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Report
(4 results)
Research Products
(115 results)
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[Journal Article] Alcohol drinking, cigarette smoking and development of squamous cell of the esophagus : Epidemiology, clinical findings, and prevention.2010
Author(s)
Morita M., Kumashiro R., Kubo N., Nakashima Y., Yoshida R., Yoshinaga K., Saeki H., Emi Y., Kakeji Y., Sakaguchi Y., Toh Y., Maehara Y
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Journal Title
Int J Clin Oncol 15(2)
Pages: 126-134
Related Report
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[Journal Article] Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route.2010
Author(s)
Morita M., Ikeda K., Sugiyama M., Saeki H., Egashira A., Yoshinaga K., Oki E., Sadanaga N., Fukushima J., Kakeji Y., Maehara Y
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Journal Title
Surgery 147(2)
Pages: 212-218
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[Journal Article] Impact of perioperative peripheral blood values on postoperative complications after esophageal surgery.2010
Author(s)
Saeki H., Masuda T., Okada S., Ando K., Sugiyama M., Yoshinaga K., Endo K., Sadanaga N., Emi Y., Kakeji Y., Morita M., Yamashita N., Maehara Y
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Journal Title
Surg Today 40(7)
Pages: 626-631
NAID
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[Journal Article] Genetic polymorphisms of CYP2E1 and risk of colorectal cancer : the Fukuoka Colorectal Cancer Study.2009
Author(s)
Morita M., Le Marchand L., Kono S., Yin G., Toyomura K., Nagano J., Mizoue T., Mibu R., Tanaka M., Kakeji Y., Maehara Y., Okamura T., Ikejiri K., Futami K., Maekawa T., Yasunami Y., Takenaka K., Ichimiya H., Imaizumu N
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Journal Title
Cancer Epidemiol Biomakers 18
Pages: 235-241
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[Journal Article] Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route.2009
Author(s)
Morita M., Ikeda K., Sugiyama M., SAeki H., Egashira A., Yoshinaga K., Oki E., Sadanaga N., Kakeji Y., Fukushima J., Maehara Y
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Journal Title
Surgery 147(2)
Pages: 212-208
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[Journal Article] Postoperative management using intensive patient-controlled epidural analgesia and eartyrehabilitation after an esophagectomy.2009
Author(s)
Saeki H., Ishimura H., Higashi H., Kitagawa D., Tanaka J., Maruyama R., Katoh H., Shimazoe H., Yamaushi K., Ayabe H., Kakeji Y., Morita M., Maehara Y
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Journal Title
Digestion 79(1)
Pages: 33-39
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[Journal Article] Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid.2008
Author(s)
Morita M., Yoshida R., Ikeda K., Egashira A., Oki E., Sadanaga N., Kakeji Y., Ichiki Y., Sugio K., Yasumoto K., Maehara Y
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Journal Title
Dis Esophagus 21(1)
Pages: 30-36
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[Journal Article] Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid.2008
Author(s)
Morita M, Yoshida R, Ikeda, K, Egashira A, Oki E, Sadanaga N, Kakeii Y, Ichiki Y, Sugio K, Yasumoto K, Maehara Y.
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Journal Title
Diseases of the Esophagus. 21
Pages: 30-36
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Peer Reviewed
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[Presentation] Clinical significance of definitive chemoradiotherapy and salvage surgery for squamous cell carcinoma of the esophagus.2010
Author(s)
Morita M., Yoshida R., Yoshinaga K., Egashira A., Saeki H., Ohga T., Kakeji Y., Emi Y., Shioyama Y., Maehara Y
Organizer
2010 Annual Meeting of the American Society of Clinical Oncology誌上発表
Place of Presentation
Chicago, USA
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[Presentation] The prognostic impact of hypoxia-inducible factor-1α and VEGF, IGF-2, p21, p53 expressions in gastric adenocarcinoma.2009
Author(s)
Kakeji Y., Mizokami K., Sumiyoshi Y., Yoshinaga K., Saeki H., Tokunaga E., Endo K., Morita M., Kitao H., Emi Y., Maehara Y
Organizer
ASCO 45th Annual Meeting 2009
Place of Presentation
Orlando, Florida poster
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