| Project/Area Number |
20591548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
KAKEJI Yoshihiro Kyushu University, 医学研究院, 准教授 (80284488)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Masaru 九州大学, 大学病院, 講師 (30294937)
SADANAGA Noriaki 九州大学, 医学研究院, 非常勤講師 (20304826)
SAEKI Hiroshi 九州大学, 大学病院, 助教 (80325448)
OHGA Takefumi 九州大学, 大学病院, 助教 (60335958)
SONODA Hideto 九州大学, 医学研究院, 学術研究員 (00465725)
EGASHIRA Akinori 九州大学, 医学研究院, 客員助教 (00419524)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 抗癌剤耐性 / DNA修復 / YB-1 / 胃癌 / 食道癌 |
|---|
| Research Abstract |
The eukaryotic Y-box binding protein-1 (YB-1) functions in various biological processes, includingtranscriptional and translational control, DNA repair, drug resistance, and cell proliferation. YB-1+/cells showed increased sensitivity to cisplatin and mitomycin C, but not to etoposide, X-ray or UV irradiation, as compared to YB-1+/+cells. YB-1 may have the capacity to exert a protective role against cytotoxic effects of DNA damaging agents, and may be involved in certain aspects of drug resistance.
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