The development of novel cancer vaccine therapy using extracorporeal circulation system with immunosuppressive substance absorption column

• Project/Area Number: 20591552
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ITOH Tsuyoshi Kyoto Prefectural University of Medicine, 医学研究科, 助教 (40420707)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 実験外科学 / 外科腫瘍学 / 腫瘍免疫学

Research Abstract

In vitro experiments focusing on the immunological effects using lymphocytes derived from cancer bearing patients suggested that immunosuppressive factors increased inthose patients limited the therapeutic effects of cancer vaccine therapy. We developedhybrid column consisted of immunosuppressive substance absorptive column covered with lipoteicoic acids for immunotherapy of cancer. Lymphocytes induced byhemoperfusion treatment using immunosuppressive substance absorption (ISA) column hold enhanced activity in humoral and cellular immunity. This column has been proven to hold immunostimulative activities determined by mixed lymphocyte reaction (MLR) and PHA test. Cancer vaccine effects in vitro as well as in vivo were also demonstrated in experiments using tumor bearing rats. Furthermore, in vivo anti-tumor effect induced by ISA column was also suggested.

Research Products

• [Journal Article] A case of neuroendocrine cell carcinoma with sigmoidvesical fistula. (2010)
  • Author(s): Kawaguchi T, Itoh T, Toma A
  • Journal Title: Case report of gastroenterology 19 Pages: 178-184
  • Peer Reviewed
• [Journal Article] A case of neuroendocrine cell carcinoma with sigmoidvesical fistula. (2010)
  • Author(s): Kawaguchi T, Itoh T, Toma A
  • Journal Title: Case Report of Gastroenterology Volume: 19 Pages: 178-184
  • Peer Reviewed
• [Journal Article] 膵管癒合異常を合併し背側膵管より発生した膵管乳頭粘液性腫瘍の一例 (2009)
  • Author(s): 川口耕、伊藤剛、上田英史、藤信明、内藤和世
  • Journal Title: 日本消化器外科学会雑誌 42 Pages: 2699-1704
  • Peer Reviewed
• [Journal Article] 膵管癒合異常を合併し背側膵管より発生した膵管乳頭粘液性腫瘍の一例 (2009)
  • Author(s): 川口耕、伊藤剛、上田英史, ら
  • Journal Title: 日本消化器外科学会雑誌 42 Pages: 1699-1704
  • Peer Reviewed
• [Journal Article] Double cancer of the cystic duct and gallbladder associated with low junction of the cystic duct. (2008)
  • Author(s): Itoh T, Fuji N, Taniguchi H, Kosuga Toshiyuki, Naito Kazuyo
  • Journal Title: Journal of hepatobiliary pancreatic surgery 15 Pages: 338-343
  • NAID: 10024157133
  • Peer Reviewed
• [Journal Article] Port site herniation of the small bowel following laparoscopy-assisted distal gastrectomy : a case report. (2008)
  • Author(s): Itoh T, Fuji N, Taniguchi H, Kawagchi Tsutomu, Naito Kazuyo
  • Journal Title: Journal of medical case report 2 Pages: 48-51
  • Peer Reviewed
• [Journal Article] Double cancer of the cystic duct and gallbladder associated with low Junction of the cystic duct. (2008)
  • Author(s): Itoh T, Fuji N, Taniguchi H, et al.
  • Journal Title: Journal of hepatobiliary pancreatic surgery 15 Pages: 338-343
  • NAID: 10024157133
  • Peer Reviewed
• [Journal Article] Port site herniation of the small bowel following laparoscopy-assisted distal gastrectomy : a case report. (2008)
  • Author(s): Itoh T, Fuji N, Taniguchi H, et al.
  • Journal Title: Journal of medical case report 2 Pages: 48-51
  • Peer Reviewed
• [Presentation] 腹腔鏡下胆嚢摘出術を施行した胆嚢捻転症の1例 (2010)
  • Author(s): 西村真澄, 伊藤剛, 當麻敦史, ら
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-18
• [Presentation] 肝細胞癌との鑑別が困難であった限局性結節性過形成の1例 (2010)
  • Author(s): 西村真澄, 伊藤剛, 当麻敦史, ら
  • Organizer: 第22回日本肝胆膵外科学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-26
• [Presentation] 肝細胞癌との鑑別が困難であった限局性結節性過形成の一例 (2010)
  • Author(s): 西村真澄、伊藤剛、藤信明、當麻敦史
  • Organizer: 第22回日本肝胆膵外科学会学術集会
  • Place of Presentation: 仙台
• [Presentation] 腹腔鏡下胆嚢摘出術を施行した胆嚢捻転症の一例 (2010)
  • Author(s): 西村真澄、伊藤剛、當麻敦史
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜
• [Presentation] 大腸癌肝転移切除術後の早期残肝再発に関する検討 (2009)
  • Author(s): 伊藤剛、藤信明、谷口弘毅、内藤和世
  • Organizer: 第21回日本肝胆膵外科学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 当院における肝胆膵手術 (2009)
  • Author(s): 伊藤剛、藤信明、中村憲司、西村真澄、当麻敦史、内藤和世
  • Organizer: 第34回京都外科医会症例検討会
  • Place of Presentation: 京都
• [Presentation] CES-D Scale を用いた研修医研修における抑うつ状態の把握 (2009)
  • Author(s): 藤信明、伊藤剛、上村宏、谷口弘毅、内藤和世
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] 膵管癒合異常を合併し、副膵管より発生した膵管内乳頭粘液性腫瘍の1例 (2009)
  • Author(s): 川口耕、伊藤剛、藤信明、當麻敦史、内藤和世
  • Organizer: 第21回日本肝胆膵外科学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 急激な経過を取った劇症型アメーバ性大腸炎 (2009)
  • Author(s): 上田英史、伊藤剛、真崎武、川口耕、佐々木裕二、當麻敦史、中村憲司、藤信明、内藤和世
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] 前方アプローチによる拡大右肝切除術を施行した巨大肝細胞癌の1例 (2009)
  • Author(s): 上田英史、伊藤剛、真崎武、川口耕、佐々木裕二、當麻敦史、中村憲司、藤信明、内藤和世
  • Organizer: 第185回近畿外科学会
  • Place of Presentation: 神戸
• [Presentation] 癒着性イレウスに対する腹腔鏡下手術の臨床的検討 (2009)
  • Author(s): 上田英史、伊藤剛、西村真澄、川尻英長、當麻敦史、中村憲司、藤信明、内藤和世
  • Organizer: 第186回近畿外科学会
  • Place of Presentation: 大阪
• [Presentation] 胆嚢管低位合流型に合併した胆嚢腫瘍と診断された3症例 (2008)
  • Author(s): 伊藤剛, 藤信明, 谷口弘毅, 内藤和世
  • Organizer: 第20回日本肝胆膵外科学会
  • Place of Presentation: 山形
  • Year and Date: 2008-05-28
• [Presentation] Port site herniation of the small bowel following laparoscopy-assisted distal gastrectomy : a case report. (2008)
  • Author(s): 伊藤剛, 藤信明, 谷口弘毅
  • Organizer: 11^<th> World congress of endscopic surgery
  • Place of Presentation: 横浜
• [Presentation] 胆〓管低位合流型に合併した胆嚢腫瘍と診断された(3)症例 (2008)
  • Author(s): 伊藤剛、藤信明、谷口弘毅、内藤和世
  • Organizer: 第20回日本肝胆膵外科学会
  • Place of Presentation: 山形
• [Presentation] 執刀医関連因子が術後成績に与える影響の検討 (2008)
  • Author(s): 伊藤剛、藤信明、谷口弘毅、内藤和世
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
• [Presentation] 大腸癌肝転移切除術後早期再発症例の検討 (2008)
  • Author(s): 伊藤剛、藤信明、谷口弘毅、天池寿、柏本錦吾、川口耕、内藤和世
  • Organizer: 第63回日本消化器外科学会総会
  • Place of Presentation: 札幌
• [Presentation] 肝動注と全身化学療法を併用して切除可能となった大腸癌肝転移の一例 (2008)
  • Author(s): 伊藤剛、藤信明、中村憲司、谷口弘毅、内藤和世
  • Organizer: 第70回日本臨床外科医学会総会
  • Place of Presentation: 東京
• [Presentation] Port site herniation of the small bowel following laparoscopy-assisted distal gastrectomy : a case report. (2008)
  • Author(s): Itoh T, Fuji N, Taniguchi H, et al.
  • Organizer: 11^<th> World congress of endoscopic surgery
  • Place of Presentation: 横浜