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Nutritional effects of the novel fat emulsion emulsified by phosphatidylglycerol after cirrhotic liver resection

Research Project

Project/Area Number 20591553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionWakayama Medical University

Principal Investigator

TAKIFUJI Katsunari  Wakayama Medical University, 医学部, 講師 (00254540)

Co-Investigator(Kenkyū-buntansha) HOTTA Tsukasa  和歌山県立医科大学, 医学部, 講師 (50244744)
NAKAMURA Masaki  和歌山県立医科大学, 医学部, 助教 (80364090)
MATSUDA Kenji  和歌山県立医科大学, 医学部, 助教 (30398458)
OKU Yoshimasa  和歌山県立医科大学, 医学部, 学内助教 (10453185)
YAMAUE Hiroki  和歌山県立医科大学, 医学部, 教授 (20191190)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords代謝栄養外科学 / 脂肪乳剤 / 外科栄養 / 肝硬変
Research Abstract

We established a novel fat emulsion emulsified by phosphatidylglycerol (PG) and evaluated the efficacy on nutritional management after cirrhotic liver resection in thioacetamide-treated rats. PG emulsion inhibited not only the increases in serum triglyceride and free fatty acids, but also inhibited increases in serum levels of phospholipids for 2 hours after rapid infusion、even in hepatectomized rats with liver cirrhosis. Thus, temporary hyperlipidemia did not occur. Triglycerides from PG emulsion transferred into the hepatic cells much more rapidly than existing emulsions emulsified by phosphatidylcholine. The infusion of PG emulsion maintained a high level of energy charge of the liver even in hepatectomized rats with liver cirrhosis. On the electron microscopic findings, PG emulsion was rapidly taken into the hepatic cells and metabolized. From the results of this study, a novel PG emulsion produced rapid clearance from the blood stream, rapid transfer into the hepatic cells, and efficacy in energy production in the hepatic cells. Thus, we speculated that a novel PG emulsion might be available for cirrhotic liver resection in which commercial fat emulsions are not used.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (1 results)

All 2010

All Journal Article (1 results)

  • [Journal Article] 脂肪乳剤投与の意義2010

    • Author(s)
      瀧藤克也、山上裕機、谷村弘
    • Journal Title

      臨床栄養別冊(JCNセレクト4)

      Pages: 88-93

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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