Clinical application and prognostication in human breast cancer using tissue quantitative fluorescence in situ hybridization.
| Project/Area Number |
20591555
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
KAMMORI Makoto Nihon University, 医学部, 非常勤講師 (50292868)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KAMOTO Takahiro 東京女子医科大学, 医学部, 教授 (70194397)
川真田 明子 東京女子医科大学, 医学部, 助教 (80360155)
鈴木 留美 東京女子医科大学, 医学部, 助教 (90439852)
天野 定雄 日本大学, 医学部, 准教授 (80159459)
坂本 明子 日本大学, 医学部, 助手 (50386025)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OBAYASHI Makio 東京女子医科大学, 医学部, 教授 (80060086)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 乳癌 / 遺伝子・染色体 / FISH / テロメア / 予後診断 / 組織FISH / 正常乳腺 / HER2遺伝子 / ER / PR / 組織Q-FISH / HER 2遺伝子 |
|---|
| Research Abstract |
We analyzed the telomere length by tissue Q-FISH. Almost breast cancer cells had shortened telomere in comparison with the normal cells. In specific four cases that showed the extremely short telomere length, the tumor size was significantly higher than other cases.
|
Report
(4 results)
Research Products
(14 results)
-
[Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence.2010
Author(s)
Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon S.S.S., Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird D.M., Nakamura K
-
Journal Title
Mechanisms of Ageing and Development 131
Pages: 614-624
Related Report
Peer Reviewed
-
[Journal Article] Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts.2008
Author(s)
Kurabayashi R, Takubo K, Aida J, Honma N, Poon SSS, Kammori M, Izumiyama-Shimomura N, Nakamura K, Tsuji1 E, Matsuura M, Ogawa T, Kaminishi1 M.
-
Journal Title
Human Pathology 39
Pages: 1647-1655
Related Report
Peer Reviewed
-
[Journal Article] Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.2008
Author(s)
Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Kammori M, Sawabe M, Arai T, Fujiwara F, Kishimoto K, Takubo K
-
Journal Title
Exp Gerontol. 43(9)
Pages: 833-9
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
