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Clinical application and prognostication in human breast cancer using tissue quantitative fluorescence in situ hybridization.

Research Project

Project/Area Number 20591555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNihon University

Principal Investigator

KAMMORI Makoto  Nihon University, 医学部, 非常勤講師 (50292868)

Co-Investigator(Kenkyū-buntansha) KAMOTO Takahiro  東京女子医科大学, 医学部, 教授 (70194397)
川真田 明子  東京女子医科大学, 医学部, 助教 (80360155)
鈴木 留美  東京女子医科大学, 医学部, 助教 (90439852)
天野 定雄  日本大学, 医学部, 准教授 (80159459)
坂本 明子  日本大学, 医学部, 助手 (50386025)
Co-Investigator(Renkei-kenkyūsha) OBAYASHI Makio  東京女子医科大学, 医学部, 教授 (80060086)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords乳癌 / 遺伝子・染色体 / FISH / テロメア / 予後診断 / 組織FISH / 正常乳腺 / HER2遺伝子 / ER / PR / 組織Q-FISH / HER 2遺伝子
Research Abstract

We analyzed the telomere length by tissue Q-FISH. Almost breast cancer cells had shortened telomere in comparison with the normal cells. In specific four cases that showed the extremely short telomere length, the tumor size was significantly higher than other cases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (8 results)

  • [Journal Article] Chromosomal instability and telomere lengths of each chromosomal arm measured by Q-FISH in human fibroblast strains prior to replicative senescence.2010

    • Author(s)
      Takubo K, Aida J, Izumiyama N, Ishikawa N, Fujiwara M, Poon S.S.S., Kondo H, Kammori M, Matsuura M, Sawabe M, Arai T, Baird D.M., Nakamura K
    • Journal Title

      Mechanisms of Ageing and Development 131

      Pages: 614-624

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts.2008

    • Author(s)
      Kurabayashi R, Takubo K, Aida J, Honma N, Poon SSS, Kammori M, Izumiyama-Shimomura N, Nakamura K, Tsuji1 E, Matsuura M, Ogawa T, Kaminishi1 M.
    • Journal Title

      Human Pathology 39

      Pages: 1647-1655

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epithelium.2008

    • Author(s)
      Aida J, Izumiyama-Shimomura N, Nakamura K, Ishikawa N, Poon SSS, Kammori M, Sawabe M, Arai T, Fujiwara F, Kishimoto K, Takubo K
    • Journal Title

      Exp Gerontol. 43(9)

      Pages: 833-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic utility of fluorescence in situ hybridization (FISH) for determination of HER2 gene amplification in breast cancer.2008

    • Author(s)
      Kammori M, Kurabayashi R, Kashio M, Sakamoto A, Yoshimoto M, Amano S, Kaminishi M, Tetsu Yamada, Takubo K
    • Journal Title

      Oncology Reports 19

      Pages: 651-656

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic utility of fluorescence in situ hybridization (FISH) for determination of HER2 gene amplification in breast cancer.2008

    • Author(s)
      Kammori M, et al
    • Journal Title

      Oncology Reports 19

      Pages: 651-656

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Luminal and cancer cells in the breast show more rapid telomere shortening than myoepithelial cells and fibroblasts.2008

    • Author(s)
      Kurabayashi R, Kammori M, et al
    • Journal Title

      Human Pathology 39

      Pages: 1647-1655

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Demonstration of telomerase activity and human telomerase reverse transcriptase(hTERT) in human parathyroid tumors2010

    • Author(s)
      Kammori M
    • Organizer
      The 21th APEC
    • Place of Presentation
      Taiwan
    • Year and Date
      2010-01-09
    • Related Report
      2010 Final Research Report
  • [Presentation] テロメレース活性とhTERT発言による副甲状腺癌補助診断への応用2010

    • Author(s)
      神森眞
    • Organizer
      第22回日本内分泌外科学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] 組織Q-FISH法によるテロメア長解析とテロメレース活性を用いた甲状腺濾胞癌の補助診断2010

    • Author(s)
      神森眞
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] テロメレース活性とhTERT発現による副甲状腺癌補助診断への応用2010

    • Author(s)
      神森眞
    • Organizer
      第22回日本内分泌外科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Demonstration of telomere measurement in human papillary carcinoma of the thyroid by tissue quantitative fluorescence in situ hybridization (Q-FISH).2009

    • Author(s)
      Kammori M, Takubo K, Yamada T
    • Organizer
      The 20th APEC
    • Place of Presentation
      Guam
    • Related Report
      2010 Final Research Report
  • [Presentation] Triple negative乳癌とHER 2 positive乳癌の臨床病理学検討2008

    • Author(s)
      神森眞, 坂本明子, 天野定雄その, 他
    • Organizer
      第46回日本癌治療学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] h-TERT発現による甲状腺濾胞癌の診断-基礎から臨床応用への展望2008

    • Author(s)
      神森眞, 小川利久, 小野瀬裕之, 山田恵美子, 清水一雄, 二村浩史, 瀬戸泰之, 山田哲
    • Organizer
      第70回日本臨床外科学会総会. (パネルディスカッション7. 甲状腺濾胞癌に対する最新の診断法と治療)
    • Place of Presentation
      東京
    • Related Report
      2010 Final Research Report
  • [Presentation] 甲状腺乳頭癌と甲状腺正常組織の組織Q-FISH法を用いたテロメア長解析2008

    • Author(s)
      神森眞、柏尾光彦、倉林理恵、坂本明子, 天野定雄, 田久保海誉
    • Organizer
      第108回日本外科学会定期学術集会(SF)
    • Place of Presentation
      長崎
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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