Signaling systems activated and liver regeneration promoted by arginine

• Project/Area Number: 20591560
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Hyogo College of Medicine
• Principal Investigator: SUZUMURA Kazuhiro Hyogo College of Medicine, 医学部, 助教 (50434949)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373) ; IIMURO Yuji 兵庫医科大学, 医学部, 准教授 (30252018) ; HIRANO Tadamiti 兵庫医科大学, 医学部, 講師 (90340968) ; SATAKE Makoto 兵庫医科大学, 医学部, 助教 (70399153)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝再生 / 蛋白合成 / アミノ酸 / アルギニン / アルギナーゼ

Research Abstract

In this study, optimum concentration of arginine or arginase inhibitor on rat liver regeneration were evaluated by liver weight, DNA synthesis and liver cell count.