| Project/Area Number |
20591567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
KODERA Yasuhiro Nagoya University, 医学系研究科, 准教授 (10345879)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70167542)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKANISHI Hayao , 愛知県がんセンター腫瘍病理学, 室長 (20207830)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 癌幹細胞 / 腹膜転移 / L1 / 増殖能 / 遊走能 / 細胞 / 臨床検査学 / 胃十二指腸外科学 / 腫瘍検査学 |
|---|
| Research Abstract |
Expression of various candidate stem cell markers was evaluated using clinical specimens from gastric cancer patients. Through this approach, role of stem cells in the formation of peritoneal metastasis was assessed. The expression of one of the markers, L1, was found to be a significant prognosticator. Furthermore, L1 was found to enhance cell proliferation and motility through activation of p-ERK, and several genes including DYRK1A were co-down-regulated by siRNA-mediated inhibition of the L1 expression. On the other hand, analysis of stem cell markers in the clinical specimens did not support the notion that stem cells had a particular role in the formation of peritoneal metastasis, and intractability of peritoneal metastasis may be attributed to other factors.
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