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An analysis of circulating tumor cells in gastric cancer patients : relation to cancer stem cells and towards clinical application

Research Project

Project/Area Number 20591568
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

OKABE Hiroshi  Kyoto University, 大学院・医学研究科, 准教授 (10335250)

Co-Investigator(Kenkyū-buntansha) KAZUTAKA Obama  京都大学, 大学院・医学研究科, 助教 (50322649)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords循環血中腫瘍細胞 / 胃癌 / Circulating tumor cell / 末梢血中腫瘍細胞 / 末梢血検査 / 癌幹細胞
Research Abstract

For primary gastric cancer to metastasize, it is necessary for tumor cells to circulate in the peripheral blood as a viable state. In this study, viable circulating tumor cells (CTCs) were successfully detected in nearly 40% of patients with highly advanced gastric cancer. Moreover, tumors of patients with positive CTCs were shown to progress earlier. Detecting CTCs can be clinically applied for selecting optimal patients for induction chemotherapy and would be useful for monitoring of therapeutic effect.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009 2008

All Journal Article (5 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Stage IV胃癌に対する「術前化学療法」:切除率の向上を目指して2010

    • Author(s)
      岡部寛、坂井義治
    • Journal Title

      癌の臨床 56(4)

      Pages: 303-310

    • Related Report
      2010 Final Research Report
  • [Journal Article] 切除不能未分化胃癌の治療2010

    • Author(s)
      岡部寛、坂井義治
    • Journal Title

      外科治療 103(4)

      Pages: 371-379

    • Related Report
      2010 Final Research Report
  • [Journal Article] Induction chemotherapy with S-1 plus cisplatin followed by surgery for the treatment of gastric cancer with peritoneal dissemination2009

    • Author(s)
      Okabe H, Ueda S, Obama K, Hosogi H, Sakai Y
    • Journal Title

      Ann Surg Oncol. 16(12)

      Pages: 3227-3236

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Video. A novel laparoscopic approach for safe and simplified suprapancreatic lymph node dissection of gastric cancer.2009

    • Author(s)
      Satoh S, Okabe H, et al.
    • Journal Title

      Surg Endosc. 23

      Pages: 436-437

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intracorporeal esophagojejunal anastomosis after laparoscopic total gastrectomy for patients with gastric cancer.2008

    • Author(s)
      Okabe H, et al.
    • Journal Title

      Surg Endosc. (未定)

    • NAID

      120001850614

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Stage IV胃癌に対する「術前化学療法」:切除率の向上を目指して2010

    • Author(s)
      岡部寛、小濱和貴、姜貴嗣、田中英治、伊丹淳、坂井義治
    • Organizer
      日本外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 切除可能進行胃癌に対する術前化学療法としてのS-1+CDDP併用療法の治療成績2009

    • Author(s)
      細木久裕、岡部寛、小濱和貴、田中英治、伊丹淳、坂井義治
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-16
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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