An analysis of circulating tumor cells in gastric cancer patients : relation to cancer stem cells and towards clinical application
| Project/Area Number |
20591568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
OKABE Hiroshi Kyoto University, 大学院・医学研究科, 准教授 (10335250)
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| Co-Investigator(Kenkyū-buntansha) |
KAZUTAKA Obama 京都大学, 大学院・医学研究科, 助教 (50322649)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 循環血中腫瘍細胞 / 胃癌 / Circulating tumor cell / 末梢血中腫瘍細胞 / 末梢血検査 / 癌幹細胞 |
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| Research Abstract |
For primary gastric cancer to metastasize, it is necessary for tumor cells to circulate in the peripheral blood as a viable state. In this study, viable circulating tumor cells (CTCs) were successfully detected in nearly 40% of patients with highly advanced gastric cancer. Moreover, tumors of patients with positive CTCs were shown to progress earlier. Detecting CTCs can be clinically applied for selecting optimal patients for induction chemotherapy and would be useful for monitoring of therapeutic effect.
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Report
(4 results)
Research Products
(7 results)
