Integrated analysis of microRNA expression and epigenetics in esophageal cancer

• Project/Area Number: 20591569
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: SATO Fumikai Kyoto University, 薬学研究科, 准教授 (20467426)
• Co-Investigator(Kenkyū-buntansha): TSUCHIYA Soken 京都大学, 薬学研究科, 助教 (80423002)
• Co-Investigator(Renkei-kenkyūsha): SHIMADA Yutaka 富山大学, 医学部, 准教授 (30216072)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 食道癌 / エピジェネティクス / マイクロRNA / microRNA

Research Abstract

In this project, an integrated analysis of epigenetic and microRNA expression in esophageal cancer cells was performed. We obtained genomewide information of DNA methylation, by high-throughput sequencer, and we showed that miR-106b cluster, miR-141, miR-210, miR-593* target p21/Bim, YAP1, EGFRL1, and PLK1, respectively, to regulate cell growth, cell cycle, chemo-resistance of esophageal cancer. This finding provided deep biological insights into esophageal cancer research field.

Research Products

• [Journal Article] microRNA発現解析技術の最近の進歩 (2011)
  • Author(s): 佐藤史顕、戸井雅和
  • Journal Title: 血管医学 8月号in press
• [Journal Article] MicroRNA and Epigenetics. (2011)
  • Author(s): Sato F, Tsuchiya S, Meltzer SJ, 清水一治
  • Journal Title: FEBS Journal, FEBS J. 278(10) Pages: 1598-609
  • Peer Reviewed
• [Journal Article] MicroRNA-141 confers resistance to cisplatin-induced apoptosis by targeting YAP1 in human esophageal squamous cell carcinoma. (2011)
  • Author(s): Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Shimizu K, Tsujimoto G
  • Journal Title: J Hum Genet. 56 Pages: 270-6
  • NAID: 10030658712
  • Peer Reviewed
• [Journal Article] MicroRNA-210 regulates cancer cell proliferation through targeting fibroblast growth factor receptor-like 1 (FGFRL1). (2011)
  • Author(s): Tsuchiya S, Fujiwara T, Sato F, Shimada Y, Tanaka E, Sakai Y, Shimizu K, Tsujimoto G
  • Journal Title: J Biol Chem. 286 Pages: 420-8
  • Peer Reviewed
• [Journal Article] MicroRNA-210 Regulates Cancer Cell Proliferation through Targeting Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) (2011)
  • Author(s): Tsuchiya S, Sato F, Shimada Y, Tanaka E, Tsujimoto G, et al.
  • Journal Title: Journal of Biological Chemistry Volume: 286(1) Pages: 420-8
  • Peer Reviewed
• [Journal Article] MicroRNA-141 Confers Resistance to Cisplatin-induced Apoptosis by Targeting YAP1 in Human Esophageal Squamous Cell Carcinoma. (2011)
  • Author(s): Imanaka Y, Tsuchiya S, Sato F, Shimada Y, Tsujimoto G, et al.
  • Journal Title: Journal of Human Genetics Volume: (in press)
  • NAID: 10030658712
  • Peer Reviewed
• [Journal Article] Polo-like Kinase 1 regulates cell proliferation and is targeted by miR-593^* in esophageal cancer. (2011)
  • Author(s): Ito T, Sato F, Shimada Y, Mori Y, Meltzer SJ, et al.
  • Journal Title: International Journal of Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] MicroRNAs and epigenetics. (2011)
  • Author(s): Sato F, Tsuchiya S, Meltzer SJ, Shimizu K.
  • Journal Title: FEBS Journal Volume: (in press)
  • Peer Reviewed
• [Journal Article] Polo-like kinase 1 regulates cell proliferation and is targeted by miR-593* in esophageal cancer. (2010)
  • Author(s): Ito T, Sato F, Kan T, Cheng Y, David S, Agarwal R, Paun BC, Jin Z, Olaru AV, Hamilton JP, Selaru FM, Yang J, Matsumura N, Shimizu K, Abraham JM, Shimada Y, Mori Y, Meltzer SJ.
  • Journal Title: Int J Cancer.(* : equally contributed)
  • Peer Reviewed
• [Journal Article] Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing. (2010)
  • Author(s): Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G
  • Journal Title: BMC Genomics. 11 Pages: 137-137
  • Peer Reviewed
• [Journal Article] TOPICS「がんにおけるマイクロRNAとエピジェネティクスの相互制御回路」 (2010)
  • Author(s): 佐藤史顕
  • Journal Title: 医学の歩み(週刊) 235巻8号 Pages: 884-5
• [Journal Article] Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing. (2010)
  • Author(s): Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G.
  • Journal Title: BMC Genomics. Volume: 11 Pages: 137-137
  • Peer Reviewed
• [Journal Article] TOPICS「がんにおけるマイクロRNAとエピジェネティクスの相互制御回路」 (2010)
  • Author(s): 佐藤史顕
  • Journal Title: 医学のあゆみ Volume: 235巻8号 Pages: 884-5
• [Journal Article] Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing. (2010)
  • Author(s): Ruike Y, Imanaka Y, Sato F, Shimizu K, Tsujimoto G
  • Journal Title: BMC Genomics 11 Pages: 137-137
  • Peer Reviewed
• [Journal Article] A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus. (2009)
  • Author(s): Jin Z, Cheng Y, Gu W, Zheng Y, Sato F, Mori Y, Olaru AV, Paun BC, Yang J, Kan T, Ito T, Hamilton JP, Selaru FM, Agarwal R, David S, Abraham JM, Wolfsen HC, Wallace MB, Shaheen NJ, Washington K, Wang J, Canto MI, Bhattacharyya A, Nelson MA, Wagner PD, Romero Y, Wang KK, Feng Z, Sampliner RE, Meltzer SJ.
  • Journal Title: Cancer Res. 69 Pages: 4112-5
  • Peer Reviewed
• [Journal Article] The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and Bim. (2009)
  • Author(s): Kan T, Sato F, Ito T, Matsumura N, David S, Cheng Y, Agarwal R, Paun BC, Jin Z, Olaru AV, Selaru FM, Hamilton JP, Yang J, Abraham JM, Mori Y, Meltzer SJ.
  • Journal Title: Gastroenterology. 136 Pages: 1689-700
  • Peer Reviewed
• [Journal Article] Intra-platform repeatability and interplatform comparability of microRNA microarraytechnology. (2009)
  • Author(s): Sato F, Tsuchiya S, Terasawa K, Tsujimoto G
  • Journal Title: PLoS One. 4
  • Peer Reviewed
• [Journal Article] Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells. (2009)
  • Author(s): Terasawa K, Ichimura A, Sato F, Shimizu K, Tsujimoto G
  • Journal Title: FEBS J. 276 Pages: 3269-76
  • Peer Reviewed
• [Journal Article] MicroRNA-338-3p and microRNA-451 contribute to the formation of basolateral polarity in epithelial cells. (2009)
  • Author(s): Tsuchiya S, Oku M, Imanaka Y, Kunimoto R, Okuno Y, Terasawa K, Sato F, Tsujimoto G, Shimizu K
  • Journal Title: Nucleic Acids Res. 37 Pages: 3821-7
  • Peer Reviewed
• [Journal Article] The miR-25-93-106b cluster members function as oncomiRs regulating p21 and Bim in Barrett's neoplasia (2009)
  • Author(s): Kan T^*, Sato F, Ito T, et al.
  • Journal Title: Gastroenterology 136(5) Pages: 1689-1700
  • Peer Reviewed
• [Journal Article] Intra-platform Repeatability and Inter-platform Comparability of MicroRNA Microarray Technology. (2009)
  • Author(s): Sato F, Tsuchiya S, Terasawa K, Tsujimoto G.
  • Journal Title: PLoS One 4(5)
  • NAID: 120002871157
  • Peer Reviewed
• [Journal Article] The miR-106b-25 polycistron, activated by genomic amplification, functions as an oncogene by suppressing p21 and (2009)
  • Author(s): Kan T, Sato, F, et al.
  • Journal Title: Gastroenterology (in press)
  • Peer Reviewed
• [Journal Article] Intra-platform Repeatability and Inter-platform Coiparability of MicroRNA Microarray Technology. (2009)
  • Author(s): Sato, F, et al.
  • Journal Title: PLoS One 4(5)
  • Peer Reviewed
• [Journal Article] MicroRNA-338-3p and niicroRNA-451 contribute to the formation of basolateral polarity in epithelial cells (2009)
  • Author(s): Tsuchiya S, et al.
  • Journal Title: Nucleic Acids Research (in press)(Apr 22 epub)
  • Peer Reviewed
• [Journal Article] A Multicenter, Double-Blinded Validation study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus (2009)
  • Author(s): Jin Z., et al.
  • Journal Title: Cancer Research (in press)
  • Peer Reviewed
• [Journal Article] Sustained activation of ERK1/2 by NGF induces microRNA-221 and 222 in PC12 cells. (2009)
  • Author(s): Terasawa T, et al.
  • Journal Title: FEBS Journal (in press)
  • Peer Reviewed
• [Journal Article] Pituitary tumor-transforming 1 increases cell motility and promotes lymph node metastasis in esophageal squamous cell carcinoma. (2008)
  • Author(s): Ito T, Shimada Y, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru A, Hamilton JP, Yang J, Abraham JM, Meltzer SJ, Sato F
  • Journal Title: Cancer Res. 68 Pages: 3214-24
  • Peer Reviewed
• [Journal Article] Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors. (2008)
  • Author(s): Jin Z, Cheng Y, Olaru A, Kan T, Yang J, Paun B, Ito T, Hamilton JP, David S, Agarwal R, Selaru FM, Sato F, Abraham JM, Beer DG, Mori Y, Shimada Y, Meltzer SJ.
  • Journal Title: Int J Cancer. 123 Pages: 2331-6
  • Peer Reviewed
• [Journal Article] Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression. (2008)
  • Author(s): Jin Z, Hamilton JP, Yang J, Mori Y, Olaru A, Sato F, Ito T, Kan T, Cheng Y, Paun B, David S, Beer DG, Agarwal R, Abraham JM, Meltzer SJ.
  • Journal Title: Cancer Epidemiol Biomarkers Prev. 17 Pages: 111-7
  • Peer Reviewed
• [Journal Article] Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis. (2008)
  • Author(s): Jin Z, Mori Y, Hamilton JP, Olaru A, Sato F, Yang J, Ito T, Kan T, Agarwal R, Meltzer SJ.
  • Journal Title: Cancer. 112 Pages: 43-9
  • Peer Reviewed
• [Journal Article] Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features. (2008)
  • Author(s): Sato F, Jin Z, Schulmann K, Wang J, Greenwald BD, Ito T, Kan T, Hamilton JP, Yang J, Paun B, David S, Olaru A, Cheng Y, Mori Y, Abraham JM, Yfantis HG, Wu TT, Fredericksen MB, Wang KK, Canto M, Romero Y, Feng Z, Meltzer SJ.
  • Journal Title: PLoS One. 3
  • NAID: 120002871158
  • Peer Reviewed
• [Journal Article] 特集・がん化学療法個別化の現状と展望、トランスクリプトーム解析に基づくがん化学療法の最適化とゲノム創薬。 (2008)
  • Author(s): 佐藤史顕、清水一治、辻本豪三
  • Journal Title: 医薬ジャーナル Vol.44, No.12 Pages: 104-108
• [Journal Article] A prevalidation study for the evaluation of serum biomarkers of Barrett's esophagus and esophageal adenocarcinoma. (2008)
  • Author(s): Drake RR, et al.
  • Journal Title: Cancer Biomarkers 4(3) Pages: 138-139
  • Peer Reviewed
• [Journal Article] Promoter hypermethylation of CDH13 is a comion, early event in human esophageal adenocarcinogenesis and correlates with clinical risk (2008)
  • Author(s): Jin Z., Sato, F, et al.
  • Journal Title: International Journal of Cancer 123(10) Pages: 2331-6
  • Peer Reviewed
• [Journal Article] Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells (2008)
  • Author(s): Iwaisako K., et al.
  • Journal Title: Journal of Hepatology 49(5) Pages: 768-78
  • Peer Reviewed
• [Journal Article] Three-tiered Risk Stratification Model to Predict Progression in Barrett's Esophagus Using Epigenetic and Clinical (2008)
  • Author(s): Sato F, et al.
  • Journal Title: PLoS One 3(4)
  • Peer Reviewed
• [Journal Article] Pituitary Tumor-transforming gene 1(PTTG1) increases cell motility and promotes lymph node metastasis in esophageal squamous cell (2008)
  • Author(s): Ito T., Sato F., et al.
  • Journal Title: Cancer Research 68(9) Pages: 3214-24
  • Peer Reviewed
• [Journal Article] 特集・がん化学療法個別化の現状と展望、トランスクリプトーム解析に基づくがん化学療法の最適化とゲノム創薬。 (2008)
  • Author(s): 佐藤史顕, 清水一治, 辻本豪三
  • Journal Title: 医薬ジャーナル 44(12) Pages: 104-108
• [Presentation] 乳癌におけるmiR-200b/a/429 clusterのEpigenetics発現調節と上皮間葉形質転換への関与 (2011)
  • Author(s): 伊藤考晃、佐藤史顕、清水一治、辻本豪三
  • Organizer: 日本薬学会
  • Place of Presentation: 静岡、東西日本大震災のため誌上開催
  • Year and Date: 2011-03-29
• [Presentation] Trastuzumabによる細胞増殖抑制に関与するmicroRNAの同定及び機能解析市川雄大 (2011)
  • Author(s): 佐藤史顕、寺澤和哉、清水一治、辻本豪三
  • Organizer: 日本薬学会
  • Place of Presentation: 静岡、東西日本大震災のため誌上開催
  • Year and Date: 2011-03-29
• [Presentation] 4P-1187, Bioinformatic identification of tissue specific microRNA targets by mRNA expression profile. (2010)
  • Author(s): Fujiwara T, Tsuchiya S, Sato F, Shimada Y, Tsujimoto G, Shimizu K
  • Organizer: 日本分子生物学会、日本生化学会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] 4P-1187, Bioinformatic identification of tissue specific microRNA targets by mRNA expression profile. (2010)
  • Author(s): Fujiwara T, Tsuchiya S, Sato F, Shimada Y, Tsujimoto G, et al.
  • Organizer: 日本分子生物学会、日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
  • Year and Date: 2010-12-10
• [Presentation] Topic 12「microRNAと循環器疾患」Overview and Latest Technologies of microRNAs (2010)
  • Author(s): Fumiaki Sato
  • Organizer: 日本循環器病学会第74回総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-06
• [Presentation] 3P-0748,4T12-8, miR-210 regulates cancer cell proliferation through targeting FGFRL1. (2010)
  • Author(s): Tsuchiya S, Fujiwara T, Sato F, Tsujimoto G, Shimizu K.
  • Organizer: 日本分子生物学会、日本生化学会合同大会
  • Place of Presentation: 神戸
• [Presentation] 3P-0748, 4T12-8, miR-210 regulates cancer cell proliferation through targeting FGFRL1. (2010)
  • Author(s): Tsuchiya S, Fujiwara T, Sato F, Tsujimoto G, Shimizu K
  • Organizer: 日本分子生物学会、日本生化学会合同大会
  • Place of Presentation: 神戸ポートアイランド(神戸市)
• [Presentation] #3P-0757, miR-X Contributes to Cisplatin Resistance of Esophageal Cancer cells. (2009)
  • Author(s): 今中由花子、土屋創健、佐藤史顕、嶋田裕、清水一治、辻本豪三
  • Organizer: 日本分子生物学会第32回年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-11
• [Presentation] Symposium 4, "Key-technology in ADMETox Next-generation High-throughput Sequencer and DNA Microarray as ADME Research Tools (2009)
  • Author(s): Fumiaki Sato, Kazuharu Shimizu
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-28
• [Presentation] Symposium 4, "Key-technology in ADMETox, Next-generation High-throughput Sequencer and DNA Microarray as ADME Research Tools (2009)
  • Author(s): Fumiaki Sato, Kazuharu Shimiz
  • Organizer: 日本薬物動態学会第24回年会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-28
• [Presentation] #10447, Polo-like Kinase 1 regulates cell proliferation and is targeted by microRNA-593* in esophageal cancer (2009)
  • Author(s): Sato F, et al.
  • Organizer: 日本癌学会第67回総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-29
• [Presentation] Screening of epigenetically controlled microRNAs in breast cancer (2009)
  • Author(s): 佐藤史顕、類家慶直、辻本豪三、清水一治
  • Organizer: 日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-01
• [Presentation] 日本人類遺伝学会第54回大会 (2009)
  • Author(s): 佐藤史顕、清水一治、辻本豪三
  • Organizer: Education Program 2、「ゲノム薬理学と個別化医療」EP2-2「発現プロファイルによるがんの個別化医療」
  • Place of Presentation: 品川
  • Year and Date: 2009-09-25
• [Presentation] #PA032、microRNA-210の発現低下による細胞周期停止機能の破綻を介した食道扁平上皮癌細胞の細胞増殖抑制メカニズムの解明 (2009)
  • Author(s): 土屋創健、佐藤史顕、藤原大、嶋田裕、辻本豪三、清水一治
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 品川
  • Year and Date: 2009-09-23
• [Presentation] #PA118、乳癌におけるエピジェネティクス調節されるマイクロRNAのゲノムワイド探索 (2009)
  • Author(s): 佐藤史顕、類家慶直、伊藤考晃、辻本豪三、清水一治
  • Organizer: 日本人類遺伝学会第54回大会
  • Place of Presentation: 品川
  • Year and Date: 2009-09-23
• [Presentation] シンポジウム11「がんの診断と治療:分子生物学の貢献」演題S11-4「癌におけるマイクロRNA発現のエピジェネティック制御」 (2009)
  • Author(s): 佐藤史顕
  • Organizer: 第41回日本臨床分子形態学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-09-05
• [Presentation] #P-83 乳がんにおけるエピジェネティクス調節を受けるマイクロRNAの探索 (2009)
  • Author(s): 佐藤史顕、類家慶直、辻本豪三、清水一治
  • Organizer: 日本エピジェネティクス研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-05-23
• [Presentation] #1388-Intra-platform Repeatability and Inter-platform Comparability of MicroRNA Microarray Technology. (2009)
  • Author(s): Sato F, Tsuchiya S, Terasawa K, Tsujimoto G
  • Organizer: 米国癌学会第100回大会
  • Place of Presentation: デンバー,USA
  • Year and Date: 2009-04-19
• [Presentation] miR-X Contributes to Cisplatin Resistance of Esophageal Cancer cells. (2009)
  • Author(s): 今中由花子、土屋創健、佐藤史顕、嶋田裕、清水一治、辻本豪三
  • Organizer: 日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Repe atability and compa r ability of microRNA microarray. (2009)
  • Author(s): Sato F, Tsuchiya S, Terasawa K, Tsujimoto G, Shimizu K
  • Organizer: アメリカ癌学会第100大会
  • Place of Presentation: Denver
• [Presentation] Late-Breaking Abstract, #4P-1510 Reproducibility and Quantitivity of microRNA microarray (2008)
  • Author(s): Fumiaki Sato, Soken Tsuchiya, Kazuya Terasawa, Gozoh Tsujimoto, Kazuharu Shimizu
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] #4P-1510 Reproducibility and Quantitivity of microRNA microarray (2008)
  • Author(s): Sato F., et al.
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] #2P-0793 MicroRNA-338 and microRNA-451 regulate localization of betal integrin into basolateral membrane (2008)
  • Author(s): Tsuchiya S, Oku M, Imanaka Y, Okuno Y, Terasawa K, Sato F, Shimizu K, Tsujimoto G
  • Organizer: 日本分子生物学会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] シンポジウムX「いよいよ本格稼働のファーマコゲノミクス」「食道癌に対するテーラーメイド医療に向けてのバイオマーカーの探索」 (2008)
  • Author(s): 佐藤史顕、土屋創健、辻本豪三、清水一治、嶋田裕
  • Organizer: 日本人類遺伝学会第53回大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-30
• [Presentation] シンポジウムX「いよいよ本格稼働のファーマコゲノミクス」。演題「食道癌に対するテーラーメイド医療に向けてのバイオマーカーの (2008)
  • Author(s): 佐藤史顕
  • Organizer: 日本人類遺伝学会第53回大会
  • Place of Presentation: 横浜
  • Year and Date: 2008-09-30
• [Presentation] #M1593 Setting the stage for Inflammatory Actors : Acid-Induced NF-κB Signaling Decreases the Apoptotic Effects of TNFαin Esophageal Adenocarcinoma Cells. (2008)
  • Author(s): David S., et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-17
• [Presentation] #M1600 Upregulation of the Mir-25-93-106b Cluster in Barrett's-Associated Neoplastic Progression. (2008)
  • Author(s): Kan T., et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-17
• [Presentation] #M2005 Down-Regulation of PTTG1 By siRNA Suppresses Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma In Vivo. (2008)
  • Author(s): Ito T., et al.
  • Organizer: 米国消化器病学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-05-17
• [Presentation] #5012 The mir-106b cluster in Barrett's esophagus and esophageal adenocarcinoma. (2008)
  • Author(s): Kan T, Sato F, Ito T, Jin Z, Olaru AV, Paun BC, David S, Selaru FM, Hamilton JP, Cheng Y, Yang J, Mori Y, Abraham JM, Meltzer SJ.
  • Organizer: AACR 2008
  • Place of Presentation: San Diego.
  • Year and Date: 2008-04-16
• [Presentation] #5012 The mir-106b cluster in Barrett's esophagus and esophaseal adenocarcinoma. (2008)
  • Author(s): Kan T., et al.
  • Organizer: 第99回米国癌学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-16
• [Presentation] #3456 Down-regulation of Polo-like Kinase 1 by siRNA drastically suppresses proliferation of esophageal cancer cells. (2008)
  • Author(s): Ito T, Sato F, Kan T, David S, Cheng Y, Mori Y, Agarwal R, Paun B, Jin Z, Olaru AV, Hamilton JP, Selaru FM, Yang J, Shimada Y, Abraham JM, Meltzer SJ.
  • Organizer: AACR 2008
  • Place of Presentation: San Diego.
  • Year and Date: 2008-04-15
• [Presentation] #3456 Down-regulation of Polo-like Kinase 1 by siRNA drastically suppresses proliferation of esophageal cancer (2008)
  • Author(s): Ito I, et al.
  • Organizer: 第99回米国癌学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-15
• [Presentation] Epigenetics in the pathogenesis of diffuse type gastric cancer (2008)
  • Author(s): Agarwal R., et al.
  • Organizer: 第99回米国癌学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-13
• [Presentation] #170 Significance of Karyopherin alfa 2 (KPNA2) expression in esophageal squamous cell carcinoma. (2008)
  • Author(s): Shimada Y., et al.
  • Organizer: 第99回米国癌学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-13
• [Presentation] #1341 Sodium salicylate reduces TNF・-induced apoptosis in SEGl EAC cells. (2008)
  • Author(s): David S, et al.
  • Organizer: 第99回米国癌学会
  • Place of Presentation: San Diego
  • Year and Date: 2008-04-13
• [Presentation] #M1600 Upregulation of the Mir-25-93-106b Cluster in Barrett's-Associated Neoplastic Progression.(Gastroenterology) (2008)
  • Author(s): Kwisa Kang, Fumiaki Sato, Tetsuo Ito, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, Florin Selaru, James P. Hamilton, Jian Yang, John M. Abraham, Stephen J. Meltzer.
  • Organizer: DDW 2008(134(4))(A379-80)
  • Place of Presentation: San Diego.
• [Presentation] #M2005 Down-Regulation of PTTG1 By siRNA Suppresses Tumorigenesis and Lymph Node Metastasis of Esophageal Squamous Cell Carcinoma In Vivo.(Gastroenterology) (2008)
  • Author(s): Tetsuo Ito, Fumiaki Sato, Kwisa Kang, Stefan David, Yulan Cheng, Yuriko Mori, Rachana Agarwal, Bogdan C. Paun, Zhe Jin, Alexandru Olaru, James P. Hamilton, Florin M. Selaru, Jian Yang, Yutaka Shimada, John M. Abraham, Stephen J. Meltzer.
  • Organizer: DDW 2008(134(4))(A-449)
  • Place of Presentation: San Diego.