| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Chemotherapy is the key of treatment of advanced esophageal squamous cell carcinoma (ESCC). Immunohistchemistry of 109 patients with ESCC revealed that NF-κB expressed in the nuclei of 60% of tumors and correlated with tumor progression. The effect of 5-FU was evaluated on the proliferation of two ESCC cell lines (TE-4 and TE-8). When cultured cells were exposed to TNFa, NF-κB translocated to the nucleus and was activated. Cells with activated NF-κB had poor sensitivity to 5-FU. After transfection with NF-κB siRNA into the cells, the level of NF-κB protein was decreased and the sensitivity against to 5-FU of cell was recovered. These results suggest that NF-κB may be a target for ESCC therapy because of its selective expression in this type of cancer.
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