The effect of i nterleukin-17 producing CD4+ T cells (T_H-17 cells) on immune system and progression of digestive cancer.
| Project/Area Number |
20591571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tottori University |
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Principal Investigator |
SAITO Hiroaki Tottori University, 医学部, 助教 (20335532)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 消化器癌 / T_H-17細胞 / インターロイキン17 / 胃癌 / ケモカイン / Tリンパ球 / IL-17 |
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| Research Abstract |
In the current study, we determined the frequency of T_H-17 cells obtained from gastric cancer patients. In addition, clinical significance of IL-17 that is mainly produced by T_H-17 cells was determined in gastric cancer patients. The frequency of T_H-17 cells in the tissue of gastric cancer was significantly more than those in peripheral blood. The concentration of IL-17, hallmark of T_H-17, in gastric cancer patients was significantly higher than that in normal controls. The prognosis of gastric cancer patients with high IL-17 concentration was significantly poor than that with low IL-17 concentration. Furthermore, multivariate analysis indicated that IL-17 concentration was an independent prognostic indicator as well as lymph node metastasis was. In conclusion, T_H-17 cells may play an extremely important role in the progression of gastric cancer though the IL-17 production.
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Report
(4 results)
Research Products
(4 results)
