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Analysis of protein phosphatase gens in esophageal squamous cell cancer

Research Project

Project/Area Number 20591576
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionIwate Medical University

Principal Investigator

IWAYA Takeshi  Iwate Medical University, 大学病院, 医員 (70405801)

Co-Investigator(Kenkyū-buntansha) NISHIDUKA Satoshi  岩手医科大学, 医学部, 講師 (50453311)
IKEDA Kenichiro  岩手医科大学, 医学部, 准教授 (20254758)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords癌 / 外科 / 遺伝子 / 蛋白質 / 食道癌 / フォスファターゼ / 遺伝子変異
Research Abstract

We identified abnormal expression of several protein phosphatase genes in esophageal squamous cell carcinoma by whole transcriptome analysis. These genes may be used as diagnostic markers and therapeutic target for esophageal squamous cell carcinomas.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (18 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Analysis of the anti-tumor effect cetuximab using protein kinetics and mouse xenograft models.2011

    • Author(s)
      T Matsuo, S Nishizuka, T Iwaya, et al.
    • Journal Title

      BMC research notes 4

      Pages: 140-140

    • Related Report
      2010 Final Research Report
  • [Journal Article] Characterization of clinically-used anticancer agents by quantitative cellular and molecular assay platforms.2010

    • Author(s)
      K Iscida, S Nishizuka, T.Iwaya, et al.
    • Journal Title

      J Iwate Med.Assoc 2(5)

      Pages: 363-375

    • NAID

      110007994980

    • Related Report
      2010 Final Research Report
  • [Journal Article] 食道癌に対する外科治療の限界2010

    • Author(s)
      木村祐輔, 岩谷岳, ら
    • Journal Title

      癌の床 56(3)

      Pages: 205-211

    • Related Report
      2010 Final Research Report
  • [Journal Article] 細胞分子生物学的定量アッセイを用いた承認済抗癌薬反応特性の解析2010

    • Author(s)
      石田和茂, ら
    • Journal Title

      岩手医学会誌

      Volume: 62(5) Pages: 363-375

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食道癌に対する外科治療の限界2010

    • Author(s)
      木村祐輔, ら
    • Journal Title

      癌の臨床

      Volume: 56(3) Pages: 205-211

    • Related Report
      2010 Annual Research Report
  • [Presentation] 食道癌におけるEMTマーカーFOXC2の臨床病理学的意義2010

    • Author(s)
      西田尚弘、三森功士、横堀武彦、古後龍之介、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、森正樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 食道癌および大腸癌細胞におけるゲノム変化の横断的解析及びその臨床病理学的意義2010

    • Author(s)
      石丸神矢、三森功士、田中文明、柴田浩平、主藤朝也、横堀武彦、西田尚弘、古後龍之介、岩谷岳、森正樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 食道癌における腫瘍抑制因子FBXW7発現の臨床的意義2010

    • Author(s)
      横堀武彦、三森功士、岩槻政晃、主藤朝也、岩谷岳、田中文明、柴田浩平、石丸神矢、西田尚弘、古後龍之介、桑野博行、森正樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腸癌におけるmiR-144の臨床的意義2010

    • Author(s)
      岩谷岳、横堀武彦、三森功士、岩槻政晃、主藤朝也、田中文明、柴田浩平、石丸神矢、古後龍之介、桑野博行、森正樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] CDDP投与後食道癌症例における組織内白金濃度の検討2010

    • Author(s)
      野口芳範、西塚哲、木村祐輔、岩谷岳、鴻巣正史、肥田圭介、佐々木章、水野大、世良耕一郎、若林剛
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Final Research Report
  • [Presentation] 食道癌におけるFN1発現の意義2010

    • Author(s)
      主藤朝也、三森功士、横堀武彦、石丸神矢、西田尚弘、古後龍之介、岩谷岳、田中文明、柴田浩平、藤田博幸、白水和雄、森正樹
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 背景肝におけるFbwx7発現の低下は肝癌患者の予後不良因子である2010

    • Author(s)
      柴田浩平、三森功士、横堀武彦、石丸神矢、西田尚弘、古後龍之介、岩谷岳、主藤朝也、田中文明、森正樹、北野正剛
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腸癌におけるcetuximab感受性予測のための細胞内シグナル伝達解析2010

    • Author(s)
      松尾鉄平、西塚哲、石田和茂、岩谷岳、木村祐輔、新田浩幸、大塚幸喜、肥田圭介、佐々木章、若林剛
    • Organizer
      第65回日本消化器外科学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 胞ライセートマイクロアレイによる蛋白ネットワーク解析と臨床応用2010

    • Author(s)
      西塚哲、石田和茂、松尾鉄平、岩谷岳、木村祐輔、新田浩幸、大塚幸喜、肥田圭介、佐々木章、若林剛
    • Organizer
      第65回日本消化器外科学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-16
    • Related Report
      2010 Final Research Report
  • [Presentation] 局所進行食道癌(cT4NxM0)に対するSalvage surgeryの治療成績2010

    • Author(s)
      藤井大和、木村祐輔、岩谷岳、野田芳範、肥田圭介、大塚幸喜、新田浩幸、佐々木章、水野大、若林剛
    • Organizer
      第65回日本消化器外科学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 高度リンパ節転移を有するStage III/IV食道癌に対するDocetaxel/CDDP/5FU療法の検討2010

    • Author(s)
      岩谷岳、木村祐輔、野田芳範、御供真吾、木村聡元、遠藤史隆、鴻巣正史、肥田圭介、佐々木章、若林剛
    • Organizer
      第65回日本消化器外科学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-15
    • Related Report
      2010 Final Research Report
  • [Presentation] 当科における食道癌手術における再建法と治療成績2010

    • Author(s)
      木村祐輔、岩谷岳、野田芳範、肥田圭介、西塚哲、新田浩幸、大塚幸喜、水野大、佐々木章、若林剛
    • Organizer
      第65回日本消化器外科学会学術集会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 大腸癌のゲノムにおけるmicroRNA領域の変異とその臨床病理学的意義2010

    • Author(s)
      石丸神矢、三森功士、田中文明、柴田浩平、主藤朝也、横堀武彦、西田尚弘、古後龍之介、岩谷岳、杉原健一、森正樹
    • Organizer
      第73回大腸癌研究会
    • Place of Presentation
      奄美大島
    • Year and Date
      2010-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation]2010

    • Author(s)
      西田尚弘、三森功士、永原誠、横堀武彦、古後龍之介、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、森正樹
    • Organizer
      第73回大腸癌研究会
    • Place of Presentation
      奄美大島
    • Year and Date
      2010-07-02
    • Related Report
      2010 Final Research Report
  • [Presentation] 高度進行食道癌に対する術前化学療法としてのDocetaxel/CDDP/5FU(DCF)療法の可能性2010

    • Author(s)
      岩谷岳, ら
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      各古屋国際会議場
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Evaluation of primary chemotherapy with docetazel, cisplatin and fluorouracil for advanced esophageal squamous cell carcinoma. American Society of Clinical Oncology2010

    • Author(s)
      T Iwaya, et al.
    • Organizer
      Gastrointestinal Cancer Symposium.
    • Place of Presentation
      Orlando, America.
    • Year and Date
      2010-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemosensitivity prediction of clinically used anticancer agents with quantitative proteomic profiling using reverse-phase lysate microarrays.2010

    • Author(s)
      K Ishida, S Nishizuka, T Iwaya, et al.
    • Organizer
      American Society of Clinical Oncology, Gastrointestinal Cancer Symposium.
    • Place of Presentation
      Orlando, America.
    • Year and Date
      2010-01-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Evaluation of primary chemotherapy with docetaxel, cisplatin and fluorouracil for advanced esophageal squamous cell carcinoma. Chemosensitivity prediction of clinically used anticancer agents with quantitative proteomic profiling using reverse-phase lysate microarrays.2010

    • Author(s)
      Iwaya, et al., Ishida, et al.
    • Organizer
      American Society of Clinical Oncology, Gastrointestinal Cancer Symposium.
    • Place of Presentation
      Orlando, America
    • Year and Date
      2010-01-22
    • Related Report
      2009 Annual Research Report
  • [Book] バイオチップ実用化ハンドブック2010

    • Author(s)
      西塚哲
    • Publisher
      ライセートアレイ
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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