| Project/Area Number |
20591580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
SASAKO Mitsuru Hyogo College of Medicine, 医学部, 教授 (40143490)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Shojiro 兵庫医科大学, 医学部, 講師 (70381960)
KAIBE Nobuaki 兵庫医科大学, 医学部, 病院助手 (40529351)
FUJIWARA Yoshinori 近畿大学, 医学部, 診療講師 (10258155)
YOSHIKAWA Reigetsu 神戸アベンチスト病院, 外科, 医師 (90319864)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 癌幹細胞 / ピロリ菌 / 食道 / 胃癌 / hedgehog情報伝達系 / シチジデアミナーゼ / 分化 / 食道・胃癌 / polycomb群 |
|---|
| Research Abstract |
Purpose
We focused to prognosis of gastric cancer patients, and the expression of AID/Epithelial-mesenchymal transition related gene in gastric cancer tissue.
Results
1. We established a database of gastric cancer patients in Hyogo Collage of Medicine, which contains clinical factor, pathological factors, the expression of AID/EMT related genes.
2. Clinicopathological features of gastric cancer are pathological heterogeneity and invasiveness. We performed quantitative real-time RT-PCR array for AID/EMT (84genes) using resected gastric cancer tissue in our hospital. EMT related gene was significantly related to invasiveness of diffuse type of cancer.
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