| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We found that advanced gastric cancer responded to chemotherapy showed lower expression of 5-FU metabolism-related genes, such as thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD). Serum levels of thioredoxin, a stress-inducible protein, in advanced cancer patients increased one or two days after injection of anti-cancer drugs, which suggests that the serum levels may correlate with tumor decay. Advanced esophageal cancer patients treated with cancer vaccine showed increased titer of cancer antigen-specific antibody. Serum thioredoxin during cancer vaccine therapy increased along with tumor growth, suggesting that the serum levels may develop to be a novel surrogate marker of tumor volume.
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