A basic study on the effect of bariatric surgeries to improve type 2 diabetes : Toward days to cure severe diabetes with surgery.

• Project/Area Number: 20591586
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tohoku University
• Principal Investigator: SHIBATA Chikashi Tohoku University, 大学院・医学系研究科, 准教授 (30455779)
• Co-Investigator(Kenkyū-buntansha): 柴田 近 東北大学, 大学院・医学系研究科, 准教授 (30270804) ; 木内 誠 東北大学, 病院, 助教 (90422146)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 消化管運動 / 消化管ホルモン / 膵液 / 胆汁 / 糖尿病 / 肥満 / metabolic surgery / 外科 / 生理学 / 動物 / 動体機能利用 / 生体機能利用

Research Abstract

In dogs, we studied the effect of bile and/or pancreatic juice diversion into the ileum on gastrointestinal motility and hormone secretion. Fasted and postprandial upper gastrointestinal motility was decreased in dogs with bile and bile/pancreatic juice diversions. Plasma levels of gastric inhibitory polypeptide were decreased in digs with pancreatic juice and bile/pancreatic juice diversions. Plasma levels of peptide tyrosine-tyrosine were decreased in digs with bile diversion.

Research Products

• [Journal Article] Effects of biliary and pancreatic juice diversion into the ileum on gastrointestinal motility and gut hormone secretion in conscious dogs. (2010)
  • Author(s): Sato M, Shibata C, Kikuchi D, Ikezawa F, Imoto H, Sasaki I.
  • Journal Title: Surgery 148 Pages: 1012-1019
  • Peer Reviewed
• [Journal Article] Effects of biliary and pancreatic juice diversion into the ileum on gastrointestinal motility and gut hormone secretion in conscious dogs. (2010)
  • Author(s): Sato M, Shibata C, et al
  • Journal Title: Surgery Volume: 148 Pages: 1102-1109
  • Peer Reviewed
• [Presentation] 胆汁・膵液の流入部位変更が消化管運動・消化管ホルモンに与える影響 (2010)
  • Author(s): 佐藤学,柴田近,鹿郷昌之,木内誠,西條文人,林啓一,生澤史江,菊地大介,井本博文,佐々木巖
  • Organizer: 第96回日本消化器病学会総会
  • Place of Presentation: 新潟市
  • Year and Date: 2010-04-23
• [Presentation] 胆汁・膵液の流入部位変更が消化管運動・消化管ホルモンに与える影響 (2010)
  • Author(s): 佐藤学,柴田近,鹿郷昌之,木内誠,西條文人,林啓一,生澤史江,菊地大介,井本博文,佐々木巖
  • Organizer: 第111回日本外科学会定期学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2010-04-08
• [Presentation] 胆汁・膵液の流入部位変更が消化管運動・消化管ホルモンに与える影響 (2010)
  • Author(s): 佐藤学、柴田近, ほか
  • Organizer: 第110日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-04-08
• [Presentation] 胆汁・膵液の流入部位変更と消化管運動との相関の検討 (2009)
  • Author(s): 佐藤学,柴田近,鹿郷昌之,木内誠,西條文人,林啓一,生澤史江,菊地大介,井本博文,佐々木巖
  • Organizer: 第51回日本消化器病学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2009-10-15
• [Presentation] 胆汁・膵液の流入部位変更と消化管運動との相関の検討 (2009)
  • Author(s): 佐藤学,柴田近,鹿郷昌之,木内誠,西條文人,林啓一,生澤史江,菊地大介,井本博文,佐々木巖
  • Organizer: 第50回日本平滑筋学会総会
  • Place of Presentation: 弘前市
  • Year and Date: 2009-07-22
• [Presentation] 消化管運動制御における胆汁・膵液の役割の検討 (2009)
  • Author(s): 佐藤学, 柴田近, 他
  • Organizer: 2009年度 日本消化器外科学会定期学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-17
• [Presentation] 消化管運動制御における胆汁・膵液の役割の検討 (2009)
  • Author(s): 佐藤学,柴田近,鹿郷昌之,木内誠,西條文人,林啓一,生澤史江,菊地大介,井本博文,佐々木巖
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2009-07-16