Function of New vascular endothelial growth factor (EG-VEGF) in colon cancer.

• Project/Area Number: 20591587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Fukui
• Principal Investigator: YAMAGUCHI Akio University of Fukui, 医学部附属病院, 教授 (10174608)
• Co-Investigator(Kenkyū-buntansha): GOI Takanori 福井大学, 医学部附属病院, 講師 (60225638)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 大腸癌 / 血管新生因子 / 浸潤 / 転移 / EG-VEGF

Research Abstract

To improve the prognosis of cancer patients, it is essential to inhibit the capacity of cancer cells for hematogenous metastasis as well as their proliferative capacity. EG-VEGF factor enhances the angiogenesis and cell invasion in colon cancer. EG-VEGF antibody that we established, inhibibites the angiogenesis and cell inavasion in colon cancer. EG-VEGF molecule-targeted therapy has the potential for improving survival rates.

Research Products

• [Journal Article] The effectiveness of transverse coloplasty in patients with ultra-lower rectal cancer. (2010)
  • Author(s): Goi T, Honda K, Katayama K, Yamaguchi A.
  • Journal Title: Int Surg. 95 Pages: 210-214
  • Peer Reviewed
• [Journal Article] Survivin-3B gene decreases the invasion-inhibitory effect of colon cancer cells with 5-fluorouracil. (2010)
  • Author(s): Sawai K, Goi T, Hirono Y, Katayama K, Yamaguchi A.
  • Journal Title: Oncol Res. 18 Pages: 541-547
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of colorectal cancers in the elderly. (2009)
  • Author(s): Goi T, Kawasaki M, Inoue T, Fujioka M, Hirono Y, Katayama K, Yamaguchi A
  • Journal Title: Int Surg. 94 Pages: 189-195
  • Peer Reviewed
• [Journal Article] Clinicopathological analysis of invading muscularis propria (T2) cancers <or =20 mm in diameter. (2008)
  • Author(s): Goi T, Kawasaki M, Hirono Y, Katayama K, Yamaguchi A.
  • Journal Title: Int Surg. 93 Pages: 1-5
  • Peer Reviewed
• [Presentation] 大腸癌肝転移と血管新生増殖因子:EG-VEGF との関連性について (2010)
  • Author(s): 五井孝憲, 山口明夫, 他
  • Organizer: 第65回日本消化器外科学会総会:シンポジウム
  • Place of Presentation: 下関
  • Year and Date: 2010-07-15
• [Presentation] 大腸癌においてEG-VEGF(endocrine glands-derived-venousendothelial growth factor) 遺伝子は細胞増殖に関与する. (2009)
  • Author(s): 五井孝憲, 山口明夫, 他
  • Organizer: 第109回日本外科学会定期学術集会:サージカルフォーラム
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-02
• [Book] 大腸癌(大腸癌の治療戦略:高齢者のStageI-III大腸癌の治療) (2010)
  • Author(s): 五井孝憲、山口明夫
  • Publisher: 日本臨床
• [Book] 2009-2010(大腸ポリープ・ポリポーシス)(消化器疾患最新治療) (2009)
  • Author(s): 五井孝憲、山口明夫
  • Publisher: 南江堂
• [Remarks] ホームページ等
  • URL: http://www.med.u-fukui.ac.jp/GEKA1