A role of FZD10, a WNT receptor, in the colon carcinogenesis.

• Project/Area Number: 20591589
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyoto University
• Principal Investigator: NAGAYAMA Satoshi Kyoto University, 有明病院消化器外科, 医長 (70362499)
• Co-Investigator(Kenkyū-buntansha): SAKAI Yoshiharu 京都大学, 医学研究科, 教授 (60273455) ; TOGUCHIDA Junya 京都大学, 再生医科学研究所, 教授 (40273502) ; KUBO Hajime 京都大学, 医学研究所, 講師 (50362520)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大腸癌 / 浸潤 / Wnt伝達系 / FZD10 / WNT伝達系 / 大腸癌発生 / 大腸癌肝転移 / 抗体療法 / 発癌

Research Abstract

Since FZD10 is located in plasma membranes as a cell-surface receptor for Wnt ligands and its expression is very low or absent in vital organs, we have focused on this molecule as a likely candidate for antibody-based therapy. We investigated the immunohistochemical expression patterns of FZD10 in tissue samples derived from patients with colorectal cancers. There was no immunoreactivity for FZD10 in normal colonic mucosa or normal liver parenchyma, whereas cancer cells in the primary and metastatic lesions showed an increased level of FZD10 expression. These results suggest that FZD10 may play a role in the progression of colorectal cancers and can be a promising candidate for a novel therapy of metastatic liver lesions from colorectal cancers.

Research Products

• [Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. (2009)
  • Author(s): Nagayama S, Yamada E, Kohno Y, Aoyama T, Fukukawa C, Kubo H, Watanabe G, Katagiri T, Nakamura Y, Sakai Y, Toguchida J
  • Journal Title: Cancer Sci 100 Pages: 405-412
  • Peer Reviewed
• [Journal Article] Activation of the non-canonical Dvl-Rac1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma (2009)
  • Author(s): Fukukawa C, Nagayama S, Tsunoda T, Toguchida J, Nakamura Y, Katagiri T
  • Journal Title: Oncogene 28 Pages: 1110-1120
  • Peer Reviewed
• [Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors (2009)
  • Author(s): Nagayama S
  • Journal Title: Cancer Science 100 Pages: 405-412
  • Peer Reviewed
• [Journal Article] Activation of the non-canonical Dvl-Rca1-JNK pathway by Frizzled homologue 10 in human synovial sarcoma (2009)
  • Author(s): Fukukawa C
  • Journal Title: Oncogene 28 Pages: 1110-1120
  • Peer Reviewed
• [Journal Article] Inverse correlation of the up-regulation of FZD10 expression and the activation of beta-catenin in synchronous colorectal tumors. (2009)
  • Author(s): Nagayama S, et al.
  • Journal Title: Cancer Sci. 100 Pages: 405-12
  • Peer Reviewed
• [Journal Article] Radioimmunotherapy of human synovial sarcoma using a monoclonal antibody against FZD10. (2008)
  • Author(s): Chikako Fukukawa, Hirofumi Hanaoka, Satoshi Nagayama, Tatsuhiko Tsunoda, Junya Toguchida, Keigo Endo, Yusuke Nakamura, Toyomasa Katagiri
  • Journal Title: Cancer Sci 99 Pages: 432-440
  • NAID: 10024002974
  • Peer Reviewed
• [Remarks] ホームページ等