Molecular mechanism for the low invasiveness of laparoscopic surgery

• Project/Area Number: 20591590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: OKAJIMA Masazumi (2010) Hiroshima University, 病院, 特任教授 (90274068); 池田 聡 (2008-2009) Hiroshima University, 医歯(薬)学総合研究科, 寄附講座講師 (60397924)
• Co-Investigator(Kenkyū-buntansha): IKEDA Satoshi 広島大学, 大学院・医歯薬学総合研究科, 寄付講座講師 (60397924) ; 岡島 正純 広島大学, 医歯(薬)学総合研究科, 寄附講座教授 (90274068)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 腹腔鏡手術 / 低侵襲手術 / 分子生物学

Research Abstract

We investigated the molecular mechanism for the low invasiveness of laparoscopic surgery. 1. Portal vein blood pH, hepatic function, and hepatic histology were disturbed in a porcine carbon dioxide pneumoperitoneum model. It may be necessary to pay attention to liver damage during laparoscopic surgery. 2. Post operative adhesions were suppressed in rat pneumoperitoneum model compared to open surgery. Plasminogen activator inhibitor-1 (PAI-1) level, which is a key molecule for post operative adhesion formation, was suppressed in serum and peritoneal lavage in pneumoperitoneum model. The PAI-1 mRNA level measured from rat and human omentum were also suppressed, which implied the mechanism of reduction for postoperative adhesions in laparoscopic surgery.

Research Products

• [Journal Article] Alterations in portal vein blood pH, hepatic function, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model (2010)
  • Author(s): Yoshida M, Ikeda S, Sumitani D, Takakura Y, Yoshimitsu M, Shimomura M, Noma M, Tokunaga M, Okajima M, Ohdan H.
  • Journal Title: Surgical Endoscopy 24(7) Pages: 1693-1700
  • Peer Reviewed
• [Journal Article] Alterations in portal vein blood pH, hepatic function, and hepatic histology in a porcine carbon dioxide pneumoperitoneum model (2010)
  • Author(s): Makoto Yoshida
  • Journal Title: Surgical Endoscopy Volume: 24(7) Pages: 1693-1700
  • Peer Reviewed
• [Journal Article] Alteration in portal vein blood pH, hepatic functions, and hepatic histology in a porcine carbon dioxide pneumoperitoneurn model (2010)
  • Author(s): Makoto Yoshida, et al
  • Journal Title: Surgical Endoscopy (掲載決定, 末定)
  • Peer Reviewed
• [Journal Article] 結腸癌に対する腹腔鏡手術は標準治療となったのか (2009)
  • Author(s): 池田聡, ら
  • Journal Title: 外科治療 101 Pages: 462-471
• [Journal Article] Abscess noted in the inguinal hernial sac after an operation for peritonitis (2009)
  • Author(s): Satoshi Ikeda, et al.
  • Journal Title: World Journal of Gastroenterology 15(8) Pages: 1007-1009
  • Peer Reviewed
• [Journal Article] 大腸外科領域における内視鏡下手術 (2009)
  • Author(s): 池田 聡
  • Journal Title: 広島医学 62(2) Pages: 58-62
  • Peer Reviewed
• [Presentation] Trend of Laparoscopic Surgery for Colorectal Cancer in Japan (2009)
  • Author(s): Masazumi Okajima, et al
  • Organizer: The 18th HCS International Symposium
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 2009-11-09
• [Presentation] 腹腔鏡下および開腹大腸癌手術のコスト比較と補助化学療法のコスト試算 (2009)
  • Author(s): 池田 聡ら
  • Organizer: 第70回大腸癌研究会
  • Place of Presentation: 東京
  • Year and Date: 2009-01-16
• [Presentation] Our procedures and devices for laparoscopic surgery for advanced colorectal cancer (2008)
  • Author(s): Satoshi Ikeda
  • Organizer: 11th World congress of Endoscopic surgery
  • Place of Presentation: Yokohama
  • Year and Date: 2008-09-05
• [Presentation] 進行大腸癌に対する腹腔鏡下手術定型化への試み (2008)
  • Author(s): 池田 聡ら
  • Organizer: 第63回日本消化器外科学会
  • Place of Presentation: 札幌
  • Year and Date: 2008-07-16
• [Remarks] ホームページ等