Effect of hyperthermia on inhibition of cancer stem cells
| Project/Area Number |
20591593
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
OOMORI Hitoshi Nara Medical University, 医学部, 博士研究員 (80213875)
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| Co-Investigator(Kenkyū-buntansha) |
KUNIYASU Hiroki 奈良県立医科大学, 医学部, 教授 (00253055)
笹平 智則 奈良県立医科大学, 医学部, 助教 (90405374)
バワール ウジャール 奈良県立医科大学, 医学部, 博士研究員 (50433339)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAHIRA Tomonori 奈良県立医科大学, 医学部, 助教 (90405374)
BHAWAL Ujjal 奈良県立医科大学, 医学部, 博士研究員 (50433339)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 小腸大腸肛門外科学 / 癌幹細胞 / 幹細胞 / 転移 / 温熱療法 / HMGB1 / 幹細胞微小環境 / 脂肪酸 |
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| Research Abstract |
For examining the factors which possess anti-cancer stem or anti-cancer stem niche effects, we focused on heat therapy, fatty acids, glycoprotein, and hypoxia. Heat therapy reduces stemness of cancer cells. In contrast, linoleic acid induces quiescent cancer stem cells to produce cancer dormancy ; and elaidic acid (trans form of oleic acid) increases proliferating cancer stem cells to enhance overt metastasis. These properties of heat therapy and fatty acids might provide a new therapeutic target.
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Report
(4 results)
Research Products
(114 results)
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[Journal Article] High mobility group box-1-inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma.2008
Author(s)
Sasahira T, Kirita T, Oue N, Bhawal UK, Yamamoto K, Fujii K, Ohmori H, Luo Y, Yasui W, Bosserhoff AK, Kuniyasu H
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Journal Title
Cancer Sci 99(9)
Pages: 1806-1812
NAID
Related Report
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[Journal Article] Basic helix-loop-helix transcription factor DEC1 negatively regulates CyclinD1.
Author(s)
Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kajima H, Kuniyasu H, Abiko Y, Kato Y, Sato S
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Journal Title
Related Report
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[Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation.
Author(s)
ItoY, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
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Journal Title
Related Report
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