| Project/Area Number |
20591595
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Digestive surgery
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
MASUDA Hideki Nihon University, 医学部, 教授 (40173752)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 日本大学, 医学部, 教授 (30238084)
TAKAHASHI Yasuo 日本大学, 医学部, 准教授 (30339329)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AIZAWA Shihoko 日本大学, 医学部, 助手 (30513858)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / オステオポンテイン / 免疫学 / 感染症 / サイトカイン / 脂質代謝 / 脂肪代謝 |
|---|
| Research Abstract |
We simultaneously examined plasma OPN levels and 17 cytokines. In UC patients, significant relationships were observed between plasma OPN levels and cytokines including IL-1β, IL-4, IL-5, IL-6, IL-7, IL-13, IFN-γ, TNF-α and GM-CSF. In the CD patients, we observed a remarkable correlation solely between OPN and IL-8. In conclusion, we posit the importance of OPN in reflecting the distinct pathophysiologies of UC and CD.
|
