T cell function in ulcerative colitis, particularly relationship between osteopontin and ulcerative colitis
| Project/Area Number |
20591595
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nihon University |
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Principal Investigator |
MASUDA Hideki Nihon University, 医学部, 教授 (40173752)
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| Co-Investigator(Kenkyū-buntansha) |
HAYAKAWA Satoshi 日本大学, 医学部, 教授 (30238084)
TAKAHASHI Yasuo 日本大学, 医学部, 准教授 (30339329)
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| Co-Investigator(Renkei-kenkyūsha) |
AIZAWA Shihoko 日本大学, 医学部, 助手 (30513858)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 潰瘍性大腸炎 / クローン病 / 炎症性腸疾患 / オステオポンテイン / 免疫学 / 感染症 / サイトカイン / 脂質代謝 / 脂肪代謝 |
|---|
| Research Abstract |
We simultaneously examined plasma OPN levels and 17 cytokines. In UC patients, significant relationships were observed between plasma OPN levels and cytokines including IL-1β, IL-4, IL-5, IL-6, IL-7, IL-13, IFN-γ, TNF-α and GM-CSF. In the CD patients, we observed a remarkable correlation solely between OPN and IL-8. In conclusion, we posit the importance of OPN in reflecting the distinct pathophysiologies of UC and CD.
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Report
(4 results)
Research Products
(4 results)
