New preservation solution for liver transplantation

• Project/Area Number: 20591602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUDOU Atsushi Tokyo Medical and Dental University, 医学部附属病院, 助教 (20376734)
• Co-Investigator(Kenkyū-buntansha): ARII Shigeki 東京医科歯科大学 (70431905) ; 有井 滋樹 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50151171)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 冷保存虚血再還流障害 / 肝移植 / 保存液 / Mrp2 / 内在化 / 微小循環障害 / 生体内異物解毒 / 脂肪肝 / 虚血再灌流障害 / 臓器保存液 / Kupffer細胞活性化 / 冷保存障害 / 再還流障害 / 肝細胞機能保存 / 低酸素 / グリチルリチン

Research Abstract

Mrp2-dependent decreased bile flow in the post-warm ischemic rat liver. Severe Macrovesicular Fatty Liver Decreases PPARγ-dependent Organic Anion Transports through Mrp2 in Rats. Preservation Solutions Alter Mrp2-Dependent Bile Flow in Cold Ischemic Rat Livers.

Research Products

• [Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid -enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model. (2010)
  • Author(s): Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Arii S, Nishiguchi S.
  • Journal Title: Hepatol Res. 40(8) Pages: 823-831
  • NAID: 10026595516
• [Journal Article] 肝疾患における血液生化学検査、肝炎ウィルスマーカー、腫瘍マーカーの見方 (2010)
  • Author(s): 工藤篤、有井滋樹
  • Journal Title: 肝胆膵 60(4) Pages: 603-611
• [Journal Article] Preservation solutions alter Mrp2-dependent bile flow in cold ischemicrat livers. (2010)
  • Author(s): Sui S, Kudo A, Suematsu M, Tanaka S, Nakamura N, Ito K, Arii S.
  • Journal Title: J Surg Res. Volume: Mar ; 159(1) Pages: 572-581
  • Peer Reviewed
• [Journal Article] 肝疾患における血液生化学検査、肝炎ウィルスマーカー、腫瘍マーカーの見方 (2010)
  • Author(s): 工藤篤、有井滋樹
  • Journal Title: 肝胆膵 Volume: 60(4) Pages: 603-611
• [Journal Article] Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model. (2010)
  • Author(s): Yoshikawa S, Iijima H, Saito M, Tanaka H, Imanishi H, Yoshimoto N, Yoshimoto T, Futatsugi-Yumikura S, Nakanishi K, Tsujimura T, Nishigami T, Kudo A, Arii S, Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 40(8) Pages: 823-831
  • NAID: 10026595516
  • Peer Reviewed
• [Journal Article] Preservation solutions alter Mrp2-dependent bile flow in cold ischemic rat livers. (2010)
  • Author(s): Sui S, 工藤篤, Suematsu M, Tanaka S, Nakamura N, Ito K, 有井滋樹
  • Journal Title: J Surg Res. Mar ; 59(1) Pages: 572-581
  • Peer Reviewed
• [Journal Article] Decreased Mrp2-dependent bile flow in the post-warm ischemic rat liver. (2009)
  • Author(s): Ban D, Kudo A, Sui S, Tanaka S, Nakamura N, Ito K, Suematsu M, Arii S
  • Journal Title: J Surg Res. 153(2) Pages: 310-316
• [Journal Article] Preservation Solutions Alter Mrp2-Dependent Bile Flow in Cold Ischemic Rat Livers. (2009)
  • Author(s): Sui S, Kudo A, Suematsu M, Tanaka S, Nakamura N, Ito K, Arii S
  • Journal Title: J Surg Res.
• [Journal Article] Decreased Mrp2-dependent bile flow in the post-warm ischemic rat liver. (2009)
  • Author(s): Ban D, 工藤篤, Ban D, 工藤篤, Sui S, Tanaka S, Nakamura N, Ito K, Suematsu M, 有井滋樹.
  • Journal Title: J Surg Res. May15 ; 153(2) Pages: 310-316
  • Peer Reviewed
• [Journal Article] 肝切除術前評価における従来法の限界と新たな評価法の提唱 (2008)
  • Author(s): 工藤篤, 猪狩享, 野口典男, 黒川敏昭, 中村典明, 田中真二, 小池盛雄, 有井滋樹
  • Journal Title: 消化器科 47(5) Pages: 577-584
• [Journal Article] 肝切除術前評価における従来法の限界と新たな評価法の提唱 (2008)
  • Author(s): 工藤篤、有井滋樹
  • Journal Title: 消化器科 47 Pages: 577-584
• [Journal Article] 肝切除術前評価における従来法の限界と新たな評価法の提唱 (2008)
  • Author(s): 工藤篤, 猪狩享, 野口典男, 黒川敏昭, 中村典明, 田中真二, 小池盛夫, 有井滋樹
  • Journal Title: 消化器科 47
• [Journal Article] Preservation solutions alter Mrp2 -dependent bile flow in post -cold ischemic rat liver
  • Author(s): Sui S, Kudo A, Suematsu M, Tanaka S, Nakamura N, Ito K, Arii s.
  • Journal Title: J Surg Res. (In press)
  • Peer Reviewed
• [Presentation] 肝移植後肝機能を保持する病態生理から考える (2011)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: 肝臓保存液京都臓器保存セミナー
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-03-19
• [Presentation] 肝移植後肝機能を保持する病態生理から考える肝臓保存液 (2011)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: 京都臓器保存セミナー
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2011-03-19
• [Presentation] 生体内異物解毒機構はNASHの重症度を決定する (2010)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: 第24回類洞壁細胞研究会
  • Place of Presentation: 福島
  • Year and Date: 2010-11-28
• [Presentation] 術後肝不全死を予期する non-invasive markerの検討 (2010)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-16
• [Presentation] 術後肝不全死を予期するnon-invasive markerの検討 (2010)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: JDDW2010
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-16
• [Presentation] Mrp2発現はNASHの重症度を左右する (2010)
  • Author(s): 工藤篤、有井滋樹
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-27
• [Presentation] Gadlinium ethoxybenzyl Diethylenetriamine Pentaacetic Acid(EOB)を用いた術前肝機能評価. (2009)
  • Author(s): 工藤篤, 野口典男, 黒川敏昭, 中村典明, 田中真二, 有井滋樹
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-02
• [Presentation] グリチルリチンとグルタチオンのCombination treatment で肝グラフト片の生体内異物解毒機構は回復する (2008)
  • Author(s): 工藤篤, 末松誠, 野口典男, 黒川敏昭, 中村典明, 田中真二, 有井滋樹
  • Organizer: 弟2 2回 肝類洞壁細胞研究会
  • Place of Presentation: 福岡
  • Year and Date: 2008-11-29
• [Presentation] 肝臓移植グラフトの予備能から考えた新規臓器保存液の提唱 (2008)
  • Author(s): 工膝篤, 光法雄介, 松村聡, 平良薫, 中村典明, 伊東浩次, 田中真二, 有井滋樹.
  • Organizer: 第108回日本外科学会定期学術集会
  • Place of Presentation: 長崎
  • Year and Date: 2008-05-15
• [Remarks] 肝臓保存液京都臓器保存セミナー