Elucidation of mechanism of mesenchymal transition in HCC.
| Project/Area Number |
20591603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKAMURA Hiroyuki Kanazawa University, 附属病院, 助教 (40377396)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 肝臓外科学 / 肝細胞癌 / Mesenchymal transition |
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| Research Abstract |
I clarified epithelial mesenchymal transition (EMT) which was transformation to treatment resistance to be often seen in local recurrence in the post-treatment (RFA and TACE) liver of the hepatocellular carcinoma (HCC). Furthermore I elucidated the molecular mechanism about EMT of HCC and clarified molecular target to prevent EMT with in vivo experimental model. It was probed that HIF-1 α has had extremely important role in EMT of the HCC and the EMT was restrained by using a repressor of HIF-1α such as valproic acid (VPA).
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Report
(4 results)
Research Products
(3 results)
