| Project/Area Number |
20591604
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKATA Takenari Shinshu University, 医学部附属病院, 講師 (70377638)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAGAWA Shinichi 信州大学, 医学部, 教授 (80229806)
MOTOYAMA Hiroaki 信州大学, 医学部附属病院, 助教(特定雇用) (20569587)
三輪 史郎 信州大学, 医学部, 准教授 (20293516)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 移植医療 / 再生医療 / 骨髄移植 / 移植・再生医療 / 骨髄細胞 |
|---|
| Research Abstract |
We used Long Evans Cinnamon (LEC) rats as recipients, a model of Wilson disease and liver carcinogenesis. GFP-expressing BMCs were injected into newborn LEC rats through the spleen.
At 18 months after injection, we found some green fluorescent protein-expressing areas macroscopically in the liver of treated LEC rats. The oxidative activity of ceruloplasmin increased. Moreover, we confirmed that the BMDHs were generated by cell fusion and was not detected in any of the neoplastic lesions or cholngiofibrotic regions.
Our results suggest that this novel strategy for creating BMDHs is effective and safe.
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