The role of calcitonin in the early phase of liver regeneration and its molecular mechanism.

• Project/Area Number: 20591606
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: YOKOYAMA Yukihiro Nagoya University, 医学系研究科, 寄附講座講師 (80378091)
• Co-Investigator(Kenkyū-buntansha): NAGINO Masato 名古屋大学, 大学院・医学研究科, 教授 (20237564) ; EBATA Tomoki 名古屋大学, 大学院・医学研究科, 准教授 (60362258) ; KOKURYO Tosio 名古屋大学, 大学院・医学研究科, 講師 (60378023) ; 西尾 秀樹 名古屋大学, 大学院・医学研究科, 准教授 (30345897)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肝再生 / カルシトニン / CGRP

Research Abstract

We hypothesized that the calcitonin plays an important role in the liver regeneration after hepatectomy. The mean level of CGRP gene in the remnant liver was rapidly increased at 1h after hepatectomy and this overexpression of CGRP gene persisted still 12h after hepatectomy. In the immunohistochemistry, there were many droplets in hepatocytes of 12h after hepatectomy. The serum CGRP level was significantly higher at 12h after hepatectomy, and as correlate with this, the serum calcium level was significantly lower at 12h after hepatectomy. In animal experiment used with the CGRP antagonist, the liver regeneration rate after 70% hepatectomy was significantly decreased in the CGRP group.

Research Products

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