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The role of PPARγ in bile duct ligation-induced hepatic injury in rats.

Research Project

Project/Area Number 20591608
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionNagoya University

Principal Investigator

EBATA Tomoki  Nagoya University, 医学系研究科, 講師 (60362258)

Co-Investigator(Kenkyū-buntansha) KOKURYO Toshio  名古屋大学, 大学院・医学系研究科, 特任助教 (60378023)
YOKOYAMA Yukihiro  名古屋大学, 大学院・医学系研究科, 寄附講座講師 (80378091)
NAGINO Masato  名古屋大学, 大学院・医学系研究科, 教授 (20237564)
SUGAWARA Gen  名古屋大学, 医学部附属病院, 助教 (00402587)
安部 哲也  名古屋大学, 愛知県がんセンター・胸部外科部, 医長 (90378092)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsPPAR_Y / 15D-PGJ_2 / PPARγ / 15d-PGJ2 / GW9662
Research Abstract

In this study, we sought to determine the effects of PPAR_Y modulation on bile duct ligation (BDL)-induced hepatic injury and on lipopolysaccharide (LPS)-induced acute obstructive cholangitis.
PPAR_Y activation with PGJ2 can be a potent therapeutic option for hepatic injury under the condition of biliary obstruction and acute obstructive cholangitis

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] 15-deoxy-delta12,14-prostaglandin J2 prevents inflammatory response and endothelial cell damage in rats with acute obstructive cholangitis.2010

    • Author(s)
      Watanabe K, Yokovama Y, Kokuryo T, Kawai K, Kitagawa T, Seki T, Nakagawa A, Nagino M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 298(3)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] The mechanism of protective effects of PPARγ activation on bile duct ligation-induced hepatic injury in rats2009

    • Author(s)
      Tomomi Kitagawa, Yukihiro Yokovama, Toshio Kokurvo, Kiyotaka Kawai, Katsutaka Watanabe, Masato Nagino.
    • Organizer
      60 th American association for the study of liver diseases
    • Place of Presentation
      Boston
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 15-Deoxy-A^<12>,^<14>-Prostaglandin J2 prevents the inflammatory response and improves the survival in rats with acute obstructive cholangitis2009

    • Author(s)
      Yukihiro Yokovama, Katsutaka Watanabe, Toshio Kokurvo, Kiyotaka Kawai, Tomomi Kitagawa, Takashi Seki, Akifumi Nakagawa, Masato Nagino.
    • Organizer
      60 th American association for the study of liver diseases
    • Place of Presentation
      Boston
    • Year and Date
      2009-11-01
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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