Phase I study of HSP70 mRNA electroplorated denritic cells in patients with hepatocellular carcinoma

Research Project

Project/Area Number	20591612
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Digestive surgery
Research Institution	Yamaguchi University
Principal Investigator	TAMESA Takao Yamaguchi University, 医学部附属病院, 助教 (30359905)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	肝細胞癌 / mRNA導入樹状細胞療法 / エレクトロポレーション法 / 第I相試験 / 癌 / 臨床 / プロテオーム / 免疫治療 / 樹状細胞療法 / プロテーム
Research Abstract	We conducted Phase I clinical trial of HSP70 mRNA-electroporated matured dendritic cells (DCs) in patients with hepatocellular carcinoma. A dose of DCs administrated subcutaneously 3 times every 3 weeks were escalated 1x10^7, 2x10^7, 3x10^7 cells. Ten patients were treated and had no serious events in this follow- up period. Two patients were CR. This treatment was safe and effective.