Phase I study of HSP70 mRNA electroplorated denritic cells in patients with hepatocellular carcinoma
Project/Area Number |
20591612
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Yamaguchi University |
Principal Investigator |
TAMESA Takao Yamaguchi University, 医学部附属病院, 助教 (30359905)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 肝細胞癌 / mRNA導入樹状細胞療法 / エレクトロポレーション法 / 第I相試験 / 癌 / 臨床 / プロテオーム / 免疫治療 / 樹状細胞療法 / プロテーム |
Research Abstract |
We conducted Phase I clinical trial of HSP70 mRNA-electroporated matured dendritic cells (DCs) in patients with hepatocellular carcinoma. A dose of DCs administrated subcutaneously 3 times every 3 weeks were escalated 1x10^7, 2x10^7, 3x10^7 cells. Ten patients were treated and had no serious events in this follow- up period. Two patients were CR. This treatment was safe and effective.
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Report
(4 results)
Research Products
(2 results)