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Effect of liver resection on the pharmacodynamics of gemcitabine hydrohloride

Research Project

Project/Area Number 20591618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionAkita University

Principal Investigator

YAMAMOTO Yuzo  Akita University, 医学系研究科, 教授 (70281730)

Co-Investigator(Kenkyū-buntansha) KUME Makoto  秋田大学, 医学部, 講師 (00372326)
UCHINAMI Hiroshi  秋田大学, 医学部, 講師 (40400486)
Research Collaborator GOTO Toru  秋田大学
YOSHIOKA Masato  秋田大学
WATANABE Go  秋田大学
IWASAKI Wataru  秋田大学
KIKUCHI Isao  秋田大学
SATO Kohei  秋田大学
NAKAGAWA Yasuhiko  秋田大学
KUDOH Kazuhiro  秋田大学
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords胆道外科学 / 胆道癌 / 補助化学療法 / ゲムシタビン / 薬物代謝動態 / 手術侵襲 / 肝切除 / 認容性 / 有害事象 / 代謝 / 肝切除術 / 個別化治療 / 周術期薬理学 / 薬剤忍容性 / 薬物動態の個体内変動 / 肝切徐術
Research Abstract

In rat partial hepatectomy model, gemcitabine administration of recommended dose resulted in higher blood concentration (1.24 times) than non-hepatectomized rat on POD 2. Ad-ministration of 80% dose could achieve the blood concentration similar to that in nonhepatectomized rat received recommended dose. However, after completion of liver regeneration on POD 14, recommended dose was necessary to achieve the expecting blood concentration. On the other hand, in the clinical setting of partial hepatectomy, administration of recommended dose of gemcitabine did not cause an excessive blood concentration in spite of reduced liver volume. However, the incidence of an adverse effect relating to bone marrow suppression was higher in the patients after hepatectomy. These result suggest that reduced tolerance for gemcitabine following hepatectomy does not simply responsible for gemcitabine pharmacodynamics in the blood.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (15 results)

All 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (9 results)

  • [Journal Article] 急速な転帰をたどった下部胆管原発の未分化癌の1例2010

    • Author(s)
      打波宇、阿部ゆき、工藤和大、久米真、南條博、山本雄造
    • Journal Title

      日消外会誌 43

      Pages: 166-171

    • NAID

      110007539270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change in the fatty acid composition of the liver with the administration of n-3 poly unsaturated fatty acids and the effects on warm ischemia/reperfu-sion injury in the rat liver.2010

    • Author(s)
      Iwasaki W, Kume M, Kudo K, Uchinami H, Kikuchi I, Nakagawa Y, Yoshioka M, Yamamoto Y.
    • Journal Title

      Shock. 33

      Pages: 306-14

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Change in the fatty acid composition of the liver with the administration of n-3 poly unsat urated fatty acids and the effects on warm ischemia/reperfu-sion injury in the rat liver.2010

    • Author(s)
      Iwasaki
    • Journal Title

      Shock

      Volume: 33 Pages: 306-314

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急速な転帰をたどった下部胆管原発の未分化癌の1例2010

    • Author(s)
      打波宇
    • Journal Title

      日消外会誌

      Volume: 43 Pages: 166-171

    • NAID

      110007539270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and prognostic significance of urinary trypsin inhibitor in patients with hepatocellular carcinoma after hepatectomy.2009

    • Author(s)
      Kikuchi I, Uchinami H, Nanjo H, Hashimoto M, Nakajima A, Kume M, Mencin A, Yamamoto Y.
    • Journal Title

      Ann Surg Oncol. 10

      Pages: 2805-17

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implication of protein kinase A for a hepato-protective mechanism of milrinone pretreatment.2009

    • Author(s)
      Satoh K, Kume M, Abe Y, Uchinami H, Yakubouski S, Takahashi T, Sato T, Yamamoto Y
    • Journal Title

      J Surg Res 155

      Pages: 32-39

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] 化学療法が原発巣には著効したが、腹膜播種が進行していた肝内胆管癌の1例2010

    • Author(s)
      阿部ゆき
    • Organizer
      第22回日本肝胆膵外科学会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2010 Annual Research Report
  • [Presentation] Surgery-affetced pharmacokinetics of gemcitabine (2',2'-difluorodeoxycitidine) after 70% hepatectomy in rats2009

    • Author(s)
      後藤徹, 久米真, 他
    • Organizer
      European Society for Surgical Research
    • Place of Presentation
      Nimes, France
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット肝切除術がゲムシタビン薬物動態に及ぼす影響2009

    • Author(s)
      久米真、後藤徹、山本雄造
    • Organizer
      第47回日本癌治療学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] 肝胆膵領域癌術後のゲムシタビン補助化学療法で肝切除によって影響される薬物認容性の変化2009

    • Author(s)
      久米真、後藤徹、山本雄造
    • Organizer
      第64回日本消化器外科学会
    • Place of Presentation
      大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Surgery-affected pharmacokinet-ics of gemcitabine (2',2'-difluorodeoxycytidine) after 70% hepatectomy in rats.2009

    • Author(s)
      Goto T, Kume M, Yamamoto Y
    • Organizer
      44^<th> Congress of the European Society for Surgical Research (ESSR)
    • Place of Presentation
      Nimes, France.
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット肝切除術による塩酸ゲムシタビン血中動態の変化2009

    • Author(s)
      後藤徹、久米真、山本雄造
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] ラット肝切除術による塩酸ゲムシタビン血中動態の変化2009

    • Author(s)
      後藤徹、久米真, 他
    • Organizer
      第109回 日本外科学会 定期学術集会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝胆膵領域癌術後のゲムシタビン補助化学療法において肝切除による薬剤忍容性の変化2009

    • Author(s)
      久米真、打波宇, 他
    • Organizer
      第64回 日本消化器外科学会 総会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラット肝切除術がゲムシタビン薬物動態に及ぼす影響2009

    • Author(s)
      久米真、山本雄造
    • Organizer
      第47回 日本癌治療学会 学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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