Participation of Wee1 gene to carcinogenesis of the pancreatic cancer in new genetically-modified mouse and clinical implications of Wee1 gene
| Project/Area Number |
20591630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
TOMINAGA Yohei Kyushu University, 医学研究院, 特任講師 (90304823)
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Eishi 九州大学, 医学研究院, 准教授 (30264021)
OHUCHIDA Kenoki 九州大学, 医学研究院, 客員助教 (20452708)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵臓外科学 / 膵癌 / 細胞周期 / microdissection / Weel / G2 / Mチェツクポイント / ノックアウトマウス / 膵臓がん / Wee1 / Mチェックポイント |
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| Research Abstract |
WEE1 mRNA expression in pancreatic cancer cell lines is higher than that in HPDE cells. Six normal pancreas tissues and 51 PDAC samples were analyzed by immunostaining. We did not find any significant association between WEE1 expression and various clinicopathologic factors in patients with pancreatic caner. There was no difference in overall survival and disease free survival between WEE1-positive and WEE1-negtive groups. Unfortunately, we did not recognize the clinical implications of Wee1 gene to the pancreatic cancer.
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Report
(4 results)
Research Products
(10 results)
