| Project/Area Number |
20591634
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
TAKAMORI Hiroshi Kumamoto University, 大学院・生命科学研究部, 講師 (90363514)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Masahiko 熊本大学, 医学部附属病院, 非常勤診療医師 (80284769)
HAYASHI Naoko 熊本大学, 医学部附属病院, 非常勤診療医師 (20452899)
HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
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| Co-Investigator(Renkei-kenkyūsha) |
OHMURAYA Masaki 熊本大学, 発生医学研究センター, 研究機関 (60398229)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | がん幹細胞 / ポリコーム群蛋白 / Bmi-1 / EZH-2 / 膵癌 / 膵管内乳頭状粘液腫瘍 / 発癌 / 転移制御 / がん根治治療 / 膵がん / 正常幹細胞 / miR-101 / 消化器がん |
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| Research Abstract |
Bmi-1, which is one of the polycomb group protein, is expressed in the nucleus of the cancer cells, but is not expressed in stroma cells in the pancreatic cancer tissues. There was no specific characteristic of expression of Bmi-1, that is, Bmi-1 distributes in the tumor tissue diffusely. There was no statistical significance of prognosis between Bmi-1 expression cases and a non-expression case of Bmi-1. EZH-2, which is also one of the polycomb group protein, is not expressed in normal pancreatic duct and adenoma, but is expressed in cancer cells. It indicated that EZH-2 might be contributed to carcinogenesis of pancreatic cancer.
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