| Project/Area Number |
20591635
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
|---|
| Research Institution | University of Miyazaki |
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Principal Investigator |
CHIJIIWA Kazuo University of Miyazaki, 医学部, 教授 (90179945)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONDO Kazuhiro 宮崎大学, 医学部, 准教授 (10244196)
KAI Masahiro 宮崎大学, 医学部, 講師 (40264379)
OHUCHIDA Jiro 宮崎大学, 医学部, 助教 (10363590)
HIDAKA Hidek 宮崎大学, 医学部, 助教 (90398264)
UCHIYAMA Shuichiro 宮崎大学, 医学部, 助教 (50437935)
NAGAIKE Koki 宮崎大学, 医学部, 助教 (70437937)
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|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 大量肝切除 / 閉塞性黄疸 / 肝不全 / トランスポーター / 門脈塞栓 |
|---|
| Research Abstract |
Excessive hepatectomy close to the hepatic reserve function has a risk to induce postoperative liver failure. The mechanisms inducing hyperbiliruninemia with respect to anion transporters were examined in rats after 90% hepatectomy and found that excreting transporter expression (Bsep, Mrp3) but not the uptake transporters (NTCP, OATP) showed a significant difference compared to 70% hepatectomy. Moreover, Biomarkers (Glypican-3, HAI-1) influencing prognosis were established in hepatocellular carcinoma.
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