Establishment of the hepatic reserve and molecular biological

• Project/Area Number: 20591635
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: University of Miyazaki
• Principal Investigator: CHIJIIWA Kazuo University of Miyazaki, 医学部, 教授 (90179945)
• Co-Investigator(Kenkyū-buntansha): KONDO Kazuhiro 宮崎大学, 医学部, 准教授 (10244196) ; KAI Masahiro 宮崎大学, 医学部, 講師 (40264379) ; OHUCHIDA Jiro 宮崎大学, 医学部, 助教 (10363590) ; HIDAKA Hidek 宮崎大学, 医学部, 助教 (90398264) ; UCHIYAMA Shuichiro 宮崎大学, 医学部, 助教 (50437935) ; NAGAIKE Koki 宮崎大学, 医学部, 助教 (70437937)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 大量肝切除 / 閉塞性黄疸 / 肝不全 / トランスポーター / 門脈塞栓

Research Abstract

Excessive hepatectomy close to the hepatic reserve function has a risk to induce postoperative liver failure. The mechanisms inducing hyperbiliruninemia with respect to anion transporters were examined in rats after 90% hepatectomy and found that excreting transporter expression (Bsep, Mrp3) but not the uptake transporters (NTCP, OATP) showed a significant difference compared to 70% hepatectomy. Moreover, Biomarkers (Glypican-3, HAI-1) influencing prognosis were established in hepatocellular carcinoma.

Research Products

• [Journal Article] Prognostic Significance of Circumferential Cell Surface Immunoreactivity of Glypican-3 in Hepatocellular Carcinoma. (2011)
  • Author(s): Yorita, K., Takahashi, N., Takai, H., Kato, A., Suzuki, M., Ishiguro, T., Ohtomo, T., Nagaike, K., Kondo, K., Chijiiwa, K., Kataoka, H.
  • Journal Title: Liver International 31(1) Pages: 120-131
• [Journal Article] Prognostic Significance of Circumferential Cell Surface Immunoreactivity of Glypican-3 in Hepatocellular Carcinoma. (2011)
  • Author(s): Yorita, K., et.al., (10/11)
  • Journal Title: Liver International Volume: 31 Pages: 120-131
  • Peer Reviewed
• [Journal Article] Expression of Hepatocyte Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes. (2010)
  • Author(s): Funagayama, M., Kondo, K., Chijiiwa, K., Kataoka, H.
  • Journal Title: World Journal of Surgery 34(7) Pages: 1563-1571
• [Journal Article] Predictive Value of Tc-99m Galactosyl Human Serum Albmin Liver SPECT on the Assessment of Functional Recovery after Partial Hepatectomy:A Comparison with CT Volumetry. (2010)
  • Author(s): Wakamatsu, H., Nagamachi, S., Kiyohara, S., Fujita, S., Kamimura, K., Nishi, R., Nagano, M., Kondou, K., Chijiiwa, K., Tamura, S
  • Journal Title: Annals of Nuclear Medicine 24(10) Pages: 729-734
• [Journal Article] Effects of Bile Acids on Rat Hepatic Mirosomal Type I 11β-hydroxysteroid Dehydrogenase. (2010)
  • Author(s): Maeda, Y., Naganuma, S., Niina, I., Shinohara, A., Koshimoto, C., Kondo, K., Chijiiwa, K.
  • Journal Title: Steroids 75(2) Pages: 164-168
• [Journal Article] Dickkopf-1 is Overexpressed in Human Pancreatic Ductal Adenocarcinoma Cells and is Involved in Invasive Growth. (2010)
  • Author(s): Takahashi, N., Fukushima, T., Yorita, K., Tanaka, H., Chijiiwa, K., Kataoka, H.
  • Journal Title: International Journal of Cancer 126(7) Pages: 1611-1620
• [Journal Article] Expression of Hepatocyte Growth Factor Activater Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcome. (2010)
  • Author(s): Funagayama, F, Kondo, K., Chijiiwa, K., Kataoka, H.
  • Journal Title: World Journal of Surgery Volume: 34 Pages: 1563-1571
  • Peer Reviewed
• [Journal Article] Effects of Bile Acids on Rat Hepatic Mirosomal Type I 11β-hydroxysteroid Dehydrogenase. (2010)
  • Author(s): Maeda, Y., et.al., (7/7)
  • Journal Title: Steroids Volume: 75 Pages: 164-168
  • Peer Reviewed
• [Journal Article] Surgical Strategy for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Based on Prognostic Factors. (2009)
  • Author(s): Kondo, K., Chijiiwa, K., Kai, M., Otani, K., Nagaike, K., Ohuchida, J., Hiyoshi, M., Nagano, M.
  • Journal Title: Journal of Gastrointestinal Surgery 13(6) Pages: 1078-1083
• [Journal Article] Prospective Randomized Controlled Study of Gastric Emptying Assessed by ^<13>C-Acetate Breath Test After Pylorus-Preserving Pancreaticoduodenectomy. Comparison between Antecolic and Vertical Retrocolic Duodenojejunostomy. (2009)
  • Author(s): Chijiiwa, K., Imamura, N., Ohuchida, J., Hiyoshi, M., Nagano, M., Otani, K., Kai, M., Kondo, K.
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Surgery 16(1) Pages: 49-55
• [Journal Article] Differential Expression of Organic Anion Transporters in Rats Subjected to 70% or 90% Hepatectomy. (2009)
  • Author(s): Sano, K., Chijiiwa, K., Kai, M., Hidaka, Y., Kanemaru, M.
  • Journal Title: Hepato-Gastroenterology 56(89) Pages: 176-180
• [Journal Article] Clinicopathologic Characteristics of Hepatocellular Carcinoma with Bile Duct Invasion. (2009)
  • Author(s): Ikenaga, N., Chijiiwa, K., Otani, K., Ohuchida, J., Uchiyama, S., Kondo, K.
  • Journal Title: Journal of Gastrointestial Surgery 13(1) Pages: 492-497
• [Journal Article] Differential Expression of Organic Anion Transporters in Rats Subjected to 70% or 90% Hepatectomy (2009)
  • Author(s): Sano, K., Chijiiwa, K., et al.
  • Journal Title: Hepato-Gastroenterology 56 Pages: 176-180
  • Peer Reviewed
• [Journal Article] Surgical Strategy for Hepatocellular Carcinoma Patients with Portal Vein Tumor Thrombus Based on Prognostic Factors (2009)
  • Author(s): Kondo, K., Chijiiwa, K., et al.
  • Journal Title: Journal of Gastrointestinal Surgery 13 Pages: 1078-1083
  • Peer Reviewed
• [Journal Article] Outcome of Surgical Treatment of Hilar Cholangiocarcinoma. (2008)
  • Author(s): Otani, K., Chijiiwa, K., Kai, M., Ohuchida, J., Nagano, M., Tsuchiya, K., Kondo, K.
  • Journal Title: Journal of Gastrointest Srugery 12(6) Pages: 1033-1040
• [Journal Article] Prospective Randomized Controlled Studv of Gastric Emptying Assessed by C^<13>-Acetate Breath Test After Pylorus-Preserving Pancreaticoduodenectomv. Comparison between Antecolic and Vertical Retrocolic Duodenojejunostomv. (2008)
  • Author(s): Chijiiwa, K., Imamura, N., Ohuchida, J., et. al.
  • Journal Title: J HBP Surg. 16 Pages: 49-55
  • Peer Reviewed
• [Journal Article] Outcome of Surgical Treatment of Hilar Cholangiocarcinoma. (2008)
  • Author(s): Otani, K., Chijiiwa, K., Kai, M., et. al.
  • Journal Title: Journal of Gastrointestinal Surgery 12 Pages: 1033-1040
  • Peer Reviewed
• [Journal Article] Expression of Hepatocyst Growth Factor Activator Inhibitor Type 1 in Human Hepatocellular Carcinoma and Postoperative Outcomes
  • Author(s): Funagayama, M., Kondo, K., Chijiiwa, K., et al.
  • Journal Title: World Journal of Surgery (in press)
  • Peer Reviewed
• [Journal Article] Differential Expression of Organic Anion Transporters in Rats Subjected to 70% or 90% Hepatectomv.
  • Author(s): Sano, K., Chijiiwa, K., Kai. M., Hidaka, Y., Kanemaru, M.
  • Journal Title: Hepato-Gastroenterology (in press)
  • Peer Reviewed
• [Presentation] Prognostic Significance of 1. Circumferential Cell Surface Immunoreactivity of Glypican-3 in Hepatocellular Carcinoma. (2011)
  • Author(s): Yorita, K., Takahashi, N., Kato, A., Suzuki, M., Ishiguro, T., Ohtomo, T., Kondo, K., Chijiiwa,K, Kataoka, H.
  • Organizer: The 3rd JCA-AACR Special Joint Conference : The Latest Advance in Liver Cancer Research
  • Place of Presentation: Chiba
• [Presentation] 肝細胞癌に対する担癌領域門脈先行クランプによる系統的肝切除術 (2010)
  • Author(s): 近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
• [Presentation] ミニシンポジウム3:肝予備能の評価:ICG血中停滞率とGSA R-maxによる肝予備能評価と肝切除術後残肝機能との相関について (2009)
  • Author(s): 近藤千博, 千々岩一男, 等
  • Organizer: 第21回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-12
• [Presentation] ラット急性肝不全モデルにおける有機アニオントランスポーターの変動 (2009)
  • Author(s): 佐野浩一郎, 千々岩一男, 甲斐真弘, 日高淑晶, 金丸幹郎
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
• [Presentation] ミニシンポジウム3;肝予備能の評価:ICG血中停滞率とGSA R-maxによる肝予備能評価と肝切除術後残肝機能との相関について (2009)
  • Author(s): 近藤千博, 千々岩一男, 甲斐真弘, 大谷和広, 長池幸樹, 大内田次郎, 旭吉雅秀, 永野元章, 長町茂樹
  • Organizer: 第21回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 名古屋
• [Presentation] シンポジウム3:胆道癌における進展度診断の新展開:胆道癌の進展度診断と予後因子 (2009)
  • Author(s): 甲斐真弘, 千々岩一男, 大内田次郎, 近藤千博, 大谷和広, 長池幸樹, 永野元章, 旭吉雅秀, 今村直哉
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Book] 消化器疾患最新の治療2011-2012(第IV章肝・胆・膵疾患-A.肝:16肝細胞癌) (2011)
  • Author(s): 近藤千博, 千々岩一男
  • Publisher: 南江堂
• [Book] 肝良性腫瘍(消化器疾患の最新の治療2009-2010.:16.) (2009)
  • Author(s): 近藤千博, 千々岩一男
  • Total Pages: 447
  • Publisher: 南江堂
• [Book] Digestive Surgery NOw No.4胆・膵外科標準手術操作のコツとトラブルシューティング:総胆管拡張症手術 (2009)
  • Author(s): 大内田次郎、千々岩一男
  • Total Pages: 169
  • Publisher: メジカルビュー社
• [Book] 消化器疾患の最新の治療2009-2010. 16. 肝良性腫瘍 (2009)
  • Author(s): 近藤千博, 千々岩一男
  • Total Pages: 447
  • Publisher: 南江堂
• [Book] Digestive Surgery NOW No. 4胆・膵外科標準手術 操作のコツとトラブルシューティング. (2009)
  • Author(s): 大内田次郎, 千々岩一男, 杉山政則, 上西紀夫, 後藤満一, 渡邊昌彦, 編集
  • Total Pages: 447
  • Publisher: メジカルビュー社
• [Remarks] ホームページ等
  • URL: http://www.med.my/in
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/1surgery/index.html
• [Remarks]
  • URL: http://www.med.miyazaki-u.ac.jp/lsurgery/index.html