| Project/Area Number |
20591636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
KENJO Akira Fukushima Medical University, 医学部, 助教 (40305355)
|
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takuro 福島県立医科大学, 医学部, 医監兼教授 (20305361)
SATOH Yoshihiro 福島県立医科大学, 医学部, 博士研究員 (60347218)
KIMURA Takashi 福島県立医科大学, 医学部, 助教 (00381369)
GOTOH Mitsukazu 福島県立医科大学, 医学部, 教授 (50162160)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 膵癌 / 樹状細胞 / OK-432 / 術前 / 腫瘍内局注 |
|---|
| Research Abstract |
On histological findings of DC group, colliquative necrosis with lymphocyte infiltration, which are uncommon findings of pancreatic cancer. CD83^+ cells were significantly accumulated in the regional lymph nodes of DC group. Two of 9 patients of DC group are currently alive over 5 years after surgery without any other adjuvant therapy. This is the first report of Preoperative EUS-guided intratumoral iDCs injection together with OK-432 for pancreatic cancer. Further investigations to confirm and to enhance antitumor response are warranted.
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