Reserch of large maf transcription factors on pancreatic cell and preadipocyte differentiation
Project/Area Number |
20591637
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Tokyo Women's Medical University |
Principal Investigator |
|
Co-Investigator(Renkei-kenkyūsha) |
TSUCHIYA Ken 東京女子医科大学, 医学部, 准教授 (00246472)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 転写因子 / インスリン / maf / siRNA / マイクロアレイ / 膵細胞 / mafA / mafB / c-maf / microarry / microarray / large maf |
Research Abstract |
Suppression of mafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells, which suggests a possible role of the transcription factor mafA in regulation of adipocyte function and differentiation. MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs, and mafA is likely involved in the regulation of hormonal systems related to glucose metabolism.
|
Report
(5 results)
Research Products
(19 results)