Reserch of large maf transcription factors on pancreatic cell and preadipocyte differentiation

• Project/Area Number: 20591637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: TSUCHIYA Mariko 東京女子医科大学, 医学部, 准教授 (00266826)
• Co-Investigator(Renkei-kenkyūsha): TSUCHIYA Ken 東京女子医科大学, 医学部, 准教授 (00246472)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 転写因子 / インスリン / maf / siRNA / マイクロアレイ / 膵細胞 / mafA / mafB / c-maf / microarry / microarray / large maf

Research Abstract

Suppression of mafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells, which suggests a possible role of the transcription factor mafA in regulation of adipocyte function and differentiation. MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs, and mafA is likely involved in the regulation of hormonal systems related to glucose metabolism.

Research Products

• [Journal Article] Kosaku Nitta and Atsushi Maeda MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs (2011)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, Mikiko Fujita, Akira Takinishi, Maiko Furukawa
  • Journal Title: Int. J. Biomed. Sci. Volume: 7(1) Pages: 19-26
• [Journal Article] MafA is a key molecule in glucose and energy balance in the central nervous system and peripheral organs. (2011)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, Mikiko Fujita, Akira Takinishi, Maiko Furukawa, Kosaku Nitta, Atsushi Maeda
  • Journal Title: Int.J.Biomed.Sci. in press.
  • Peer Reviewed
• [Journal Article] Supression of MafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells (2009)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Ayume Suzuki, Kazuki Yasuda, Takumi Yoshida, Kosaku Nitta and Ken Tsuchiya
  • Journal Title: Int. J. Mol. Med. Volume: 23 Pages: 725-732
• [Journal Article] Supression of MafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells (2009)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Ayume Suzuki, Kazuki Yasuda, Takumi Yoshida, Kosaku Nitta, Ken Tsuchiya
  • Journal Title: Int.J.Mol.Med. 23 Pages: 725-732
  • Peer Reviewed
• [Journal Article] Suppression of MafA mRNA with siRNA prevents adipose cell differentiation in 3T3-L1 cells (2009)
  • Author(s): Mariko Tsuchiya, et.al.
  • Journal Title: International Journal of Molecular Medicine 23 Pages: 725-732
  • Peer Reviewed
• [Journal Article] MafA is a key molecule in glucose and energy balance in the central Nervous system and peripheral organs
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, et.al.
  • Journal Title: International Journal of Biomedical Science Volume: (In press)
  • Peer Reviewed
• [Presentation] Transcription factor mafB and a functional link to E-cadherin expression in b cell differentiation (2011)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kosaku Nitta, Atsushi Maeda
  • Organizer: 71st scientific sessions of American Diabetes Association
  • Place of Presentation: San Diego, CA
• [Presentation] Transcription factor mafB is implicated in regulation of expression of lipocalin2 and EMT-related genes as well as genes composing of developing pancreas (2010)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Kosaku Nitta, Ken Tsuchiya
  • Organizer: 70^<th> scientific session of American Diabetic Association
  • Place of Presentation: Orland, FL
• [Presentation] Transcription factor mafB is implicated in regulation of expression of lipocalin2 and EMT-related genes as well as genes composing of developing pancreas. (2010)
  • Author(s): Mariko Tsuchiya
  • Organizer: 70^<th> scientific session of American Diabetic Association
  • Place of Presentation: Orland, FL
• [Presentation] Transcription factor MafB is implicated in regulation of expression of lipocalin2 and EMT-related genes as well as genes composing of developing pancreas (2010)
  • Author(s): Mariko Tsuchiya, Atsushi Meda Kosaku Nitta, Ken Tsuchiya
  • Organizer: 70^<th> scientific session of American Diabetic Association
  • Place of Presentation: Orlando, FL USA
• [Presentation] MafA is a key molecule in glucose and energy balance in the central nervous system as in the peripheral organs (2009)
  • Author(s): Mariko Tsuchiya, Ken Tsuchiya, Kazuki Yasuda, Ayume Suzuki, Atsushi Maeda
  • Organizer: 69^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: New Orleans, LA
• [Presentation] Functional role of transcription factor of mafB in vivo assessed by siRNA techinique and microarray analysis (2009)
  • Author(s): Mariko Tsuchiya, Ayume Suzuki, Akiko Hayashi, Junko Tanaka, Ken Tsuchiya Atsushi Maeda
  • Place of Presentation: Viena
• [Presentation] MafA is a key molecule in glucose and energy balance in the central nervous system as in the peripheral organs. (2009)
  • Author(s): Mariko Tsuchiya
  • Organizer: 69^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: New Orleans, LA
• [Presentation] Functional role of transcription factor of mafB in vivo assessed by siRNA techinique and microarray analysis. (2009)
  • Author(s): Mariko Tsuchiya
  • Place of Presentation: Viena
• [Presentation] MafA is a key molecule in glucose and energy balance in the central nervous system as in the peripheral organs (2009)
  • Author(s): Mariko Tsuchiya
  • Organizer: 69^<th> Scientific sessions of American Diabetes Association
  • Place of Presentation: New Orleans, LA
• [Presentation] Functional roles of transcriptional factor mafB in vivo assessed by siRNA technique and microarray analysis (2009)
  • Author(s): Mariko Tsuchiya
  • Organizer: 45^<th> EASD Annual Meeting
  • Place of Presentation: Vienna
• [Presentation] Supression of mafA mRNA attenuates morphology and functions of adipocyte differentiation by 3T3-L1 cells (2008)
  • Author(s): Mariko Tsuchiya, Atsushi Maeda, Kazuki Yasuda, Ken Tsuchiya
  • Organizer: 68^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: San Francisco, CA
• [Presentation] Supression of mafA mRNA attenuates morphology and functions of adipocyte differentiation by 3T3-L1 cells. (2008)
  • Author(s): Mariko Tsuchiya
  • Organizer: 68^<th> scientific sessions of American Diabetic Association
  • Place of Presentation: San Francisco, CA
• [Presentation] Suppression of MafA mRNA with siRNA Attenuates Morpholpgy and Function of Adipocyte Differentiation by 3T3-L1Cells (2008)
  • Author(s): Mariko Tsuchiya
  • Organizer: 68^<th> scientitific sessions of American Diabetic Association
  • Place of Presentation: San Francisco, CA USA