ヒト膵臓癌におけるシーエックスシーケモカインの検討(予後・背景因子・分化度)

• Project/Area Number: 20591640
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hyogo College of Medicine
• Principal Investigator: SATAKE Makoto Hyogo College of Medicine, 医学部, 助教 (70399153)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373) ; KURODA Nobukazu 兵庫医科大学, 医学部, 講師 (20301658) ; HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968) ; UYAMA Naoki 兵庫医科大学, 医学部, 助教 (70402873) ; SUZUMURA Kazuhiro 兵庫医科大学, 医学部, 助教 (50434949)
• Co-Investigator(Renkei-kenkyūsha): HOWARD A Reber David Geffen school of Medicine at UCLA. Laboratory Director of Ronald S. Hirshberg Translation Pancreatic Cancer Research Laboratory, Professor of General Surgery ; GO VLiang Scientific Adivisory Board. David Geffen school of Medicine at UCLA. Laboratory Director of Ronald S. Hirshberg Translation Pancreatic Cancer Research Laboratory. Chief editor of journal Pancreas, Chair
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 膵臓癌 / ケモカイン / 血管新生 / レセプターシグナル / 増殖転移

Research Abstract

In human pancreatic cancer cell lines and tissue from patients with pancreatic cancer. Angiogenetic ELR+CXCL and its receptor CXCR2 were elevated. This over expression was correlated with the calcification of pancreatic cancer

Research Products

• [Presentation] The role of CXCLs and receptors CXCR2 and CXCR3 on human PaCa growth. (2010)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Hines O.J., Reber H.A., Go V.L., Uyama N., Suzumura K., Fujimoto J.
  • Organizer: American pancreatic association meeting.
  • Place of Presentation: Chicago, IL.U.S
• [Presentation] ヒト膵臓癌発育におけるCOX-2, PGE2の役割 (2010)
  • Author(s): 佐竹真、黒田暢一、平野公通、岡田敏弘、Eibl G、Reber H.A., Go V.L、宇山直樹、鈴村和大、Hines O.J., 藤元治朗
  • Organizer: 日本膵臓病学会総会+IAP joint meeting.
  • Place of Presentation: Fukuoka, Japan
• [Presentation] COX-2 dependent expression of angiogenic CXC chemokines ligand in human pancreatic cancer cell line. (2010)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Reber H.A., Go V.L., Uyama N., Suzumura K., Hines O.J., Fujimoto J.
  • Organizer: 2010 AGA Meeting
  • Place of Presentation: New Orleans. US
• [Presentation] COX-2 dependent expression of angiogenic CXC chemokines ligand in human pancreatic cancer cell line. (2010)
  • Author(s): Satake Makoto
  • Organizer: 2010 AGA Meeting
  • Place of Presentation: New Orleans US
• [Presentation] ヒト膵臓癌発育におけるCOX-2, PGE2の役割 (2010)
  • Author(s): Satake Makoto
  • Organizer: 日本膵臓病学会総会+IAP joint meeting
  • Place of Presentation: Fukuoka, Japan
• [Presentation] The role of CXCLs and receptors CXCR2 and CXCR3 on human PaCa growth (2010)
  • Author(s): Satake Makoto
  • Organizer: American pancreatic association meeting.
  • Place of Presentation: Chicago, IL U.S
• [Presentation] The role of CXCLs and receptors CXCR2 and CXCR3 on human PaCa growth. (2009)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Reber H.A., Go V.L., Uyama N., Suzumura K., Fujimoto J.
  • Organizer: 40^<th>.Joint Meeting of American pancreatic association and Japan Pnacreas Society.
  • Place of Presentation: Hawaii. U.S
• [Presentation] ヒト膵臓癌発育におけるCOX-2, PGE2の役割 (2009)
  • Author(s): 佐竹真、黒田暢一、平野公通、岡田敏弘、Eibl G、Reber H.A., Go V.L、宇山直樹、鈴村和大、Hines O.J., 藤元治朗
  • Organizer: 日本膵臓病学会総会
  • Place of Presentation: 東京、日本
• [Presentation] Characterization of Pancreatic cancer cell by COX-2 dependent growth. (2009)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Reber H.A., Go V.L., Uyama N., Suzumura K., Fujimoto J.
  • Organizer: AGA Meeting
  • Place of Presentation: Chicago, IL.U.S.
• [Presentation] Characterization of Pancreatic cancer cell by COX-2 dependent growth (2009)
  • Author(s): Satake Makoto
  • Organizer: AGA Meeting
  • Place of Presentation: Chicago.US
• [Presentation] ヒト膵臓癌発育におけるCOX-2,PGE2の役割 (2009)
  • Author(s): 佐竹真
  • Organizer: 日本膵臓病学会総会
  • Place of Presentation: 東京 日本
• [Presentation] The role of CXCLs and receptors CXCR2 and CXCR3 on human PaCa growth (2009)
  • Author(s): Satake Makoto
  • Organizer: American pancreatic association meeting.
  • Place of Presentation: Hawaii U.S
• [Presentation] The role of SCF/KIT system in pancreatic transdifferentiation. (2008)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Reber H.A., Go V.L., Uyama N., Suzumura K., Fujimoto J., Tsujimura T.
  • Organizer: American pancreatic association meeting.
  • Place of Presentation: Chicago, IL.U.S
• [Presentation] 膵幹細胞からの膵細胞再生についての検討,Tyrosine kinase receptorの役割 (2008)
  • Author(s): 佐竹真、黒田暢一、平野公通、岡田敏弘、Eibl G、Reber H.A., Go V.L、宇山直樹、鈴村和大、藤元治朗, 辻村亨
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 札幌 日本
• [Presentation] Pancreatic transdifferentiation induced from stem cell. (2008)
  • Author(s): Satake M., Kuroda N., Eibl G., Hirano T., Okada T., Reber H.A., Go V.L., Uyama N., Suzumura K., Fujimoto J., Tsujimura T.
  • Organizer: AGA Meeting
  • Place of Presentation: San Diego. CA.US
• [Presentation] Pancreatic transdifferentiation induced from stem cell (2008)
  • Author(s): Satake Makoto
  • Organizer: AGA Meeting
  • Place of Presentation: Los Angeles. US
• [Presentation] 膵幹細胞からの膵細胞再生についての検討, Tyrosine kinase receptorの役割 (2008)
  • Author(s): 佐竹真
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 札幌日本
• [Presentation] The role of SCF/KIT system in pancreatic transdifferentiation (2008)
  • Author(s): Satake Makoto
  • Organizer: American pancreatic association meeting.
  • Place of Presentation: Chicago U. S
• [Book] 胆と膵(膵癌におけるプロスタグランディン 膵基礎研究の新しい潮流 vol.31.No6) (2010)
  • Author(s): 佐竹真、黒田暢一、藤元治朗
  • Publisher: 医学図書出版
• [Book] 胆と膵vol.31.No6膵基礎研究の新しい潮流 (2010)
  • Author(s): 佐竹真, 藤元治朗
  • Publisher: 医学図書出版
• [Book] 腫瘍マーカーハンドブック(改訂版) (2010)
  • Author(s): 佐竹真, 藤元治朗
  • Total Pages: 295
  • Publisher: 医薬ジャーナル者
• [Book] Span-1,腫瘍マーカーハンドブック(石井勝編集) (2009)
  • Author(s): 佐竹克介,佐竹真,藤元治朗
  • Publisher: 医薬ジャーナル