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Pioglitazone prevented the neointimal hyperplasia at the site of anastomosis

Research Project

Project/Area Number 20591646
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionKobe University

Principal Investigator

OKADA Kenji  Kobe University, 医学部附属病院, 特命准教授 (90284356)

Co-Investigator(Kenkyū-buntansha) OKITA Yutaka  神戸大学, 医学(系)研究科(研究院), 教授 (40322193)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心臓血管外科学 / 小口径人工血管 / ピオグリタゾン / 吻合部狭窄
Research Abstract

Small caliber (〓2mm) prosthetic graft for coronary artery bypass grafting has not been developed for clinical use. The major cause of sticking point is the neointimal hyperplasia at the site of anastomosis. In the current study, we used a rat aortic interposition model with autologous femoral vein. Oral dose of Pioglitazone successfully prevented graft degeneration including the neointimal hyperplasia at the anastomosis. We are now under investigation for the prevention of neointimal hyperplasia at the anastomosis of small-caliber vascular prosthesis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Pioglitazone preserves vein graft integrity in a rat aortic interposition model2010

    • Author(s)
      Zhi Chen, Tomomi Hasegawa, Akiko Tanaka, Yutaka Okita, Kenji Okada
    • Journal Title

      J Thorac Cardiovasc Surg. 140(2)

      Pages: 408-416

    • NAID

      120003272518

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone preserves vein graft integrity in a rat aortic interposition model2010

    • Author(s)
      Zhi Chen, Tomomi Hasegawa, Akiko Tanaka, Yutaka Okita, Kenji Okada
    • Journal Title

      J Thorac Cardiovasc Surg

      Volume: 140 Pages: 408-416

    • NAID

      120003272518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pioglitazone preserves vein graft integrity in a rat aortic interposition model

    • Author(s)
      Zhi Chen, Tomomi Hasegawa, Akiko Tanaka, Yutaka Okita, Kenji Okada
    • Journal Title

      J Thorac Cardiovasc Surg (印刷中, 掲載確定)

    • NAID

      120003272518

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ピオグリタゾンによる静脈グラフト劣化抑制効果に関する実験的検討2009

    • Author(s)
      陳志, 岡田健次、長谷川智巳、田中亜紀子、大北裕
    • Organizer
      第109回日本外科学会定期学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-04
    • Related Report
      2010 Final Research Report
  • [Presentation] ピオグリタゾンによる静脈グラフト劣化抑制効果に関する実験的検討2009

    • Author(s)
      陳志
    • Organizer
      第109回日本外科学会定期学術総会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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