The Cardioprotective Effect of Bone Marrow Stem Cells in the Late Phase of Ischemic Preconditioning

• Project/Area Number: 20591648
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: MORIKAGE Noriyasu Yamaguchi University, 医学部附属病院, 講師 (50335741)
• Co-Investigator(Kenkyū-buntansha): 古谷 彰 山口大学, 医学部附属病院, 学術研究員 (90346552) ; 李 桃生 山口大学, 大学院・医学系研究科, 講師 (50379997)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Ischemic preconditioning / 虚血再灌流障害 / 幹細胞 / 骨髄幹細胞 / 虚血プレコンディショニング / Ischemic Preconditioning

Research Abstract

Ischemic preconditioning is an innate phenomenon in which brief exposure to sublethal ischemia provides tissue protection from ischemia/reperfusion injury. But the precise mechanisms of organ protection by ischemic preconditioning are unclear. This study shows that the enhanced mobilization and recruitment of bone marrow stem cells play an important role in the late phase of ischemic preconditioning.

Research Products

• [Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase. (2009)
  • Author(s): Kamota T, Li TS, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Ikeda Y, Matsuzaki M, Hamano K.
  • Journal Title: J Am Coll Cardiol. 53(19) Pages: 1814-22
  • Peer Reviewed
• [Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase (2009)
  • Author(s): Takahiro Kamota
  • Journal Title: Journal of the American College of Cardiology 53 Pages: 1814-1822
  • Peer Reviewed
• [Journal Article] Ischemic preconditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase (2009)
  • Author(s): Kamota T, et al
  • Journal Title: Journal of the American College of Cardiology (in press)
  • Peer Reviewed
• [Journal Article] Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells. (2008)
  • Author(s): Li TS, Takahashi M, Ohshima M, Qin SL, Kubo M, Muramatsu K, Hamano K.
  • Journal Title: Cell Transplant. 17(6) Pages: 695-703
  • Peer Reviewed
• [Journal Article] Myocardial repair achieved by the intramyocardial implantation of adult cardiomyocytes in combination with bone marrow cells (2008)
  • Author(s): Li TS, et al
  • Journal Title: Cell Transplantation 17 Pages: 695-703
  • Peer Reviewed
• [Presentation] 虚血プレコンディショニングによる心筋保護効果における骨髄幹細胞の関与 (2010)
  • Author(s): 鴨田隆弘、李桃生、濱野公一
  • Organizer: 第9回再生心臓血管外科治療研究会
  • Place of Presentation: 神戸、神戸国際会議場
  • Year and Date: 2010-02-15
• [Presentation] 虚血プレコンディショニングによる心筋保護効果における骨髄幹細胞の関与 (2010)
  • Author(s): 鴨田隆弘
  • Organizer: 第9回再生心臓血管外科治療研究会
  • Place of Presentation: 神戸
  • Year and Date: 2010-02-15
• [Presentation] Ischemic preconditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase (2008)
  • Author(s): Kamota T, Li TS,, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Hamano K
  • Organizer: American Heart Association Scientific Sessions 2008
  • Place of Presentation: New Orleans, Ernest N. Morial Convention Center, USA
  • Year and Date: 2008-11-10
• [Presentation] Ischemic preconditioning enhances the mobilization and recruitment of bone marrowstem cells to protect against ischemia/reperfusion injury in the late phase (2008)
  • Author(s): Takahiro Kamota
  • Organizer: American Heart Association Scientific Sessions 2008
  • Place of Presentation: New Orleans (U.S.A.)
  • Year and Date: 2008-11-10
• [Remarks] ホームページ等 なし