The Cardioprotective Effect of Bone Marrow Stem Cells in the Late Phase of Ischemic Preconditioning
| Project/Area Number |
20591648
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MORIKAGE Noriyasu Yamaguchi University, 医学部附属病院, 講師 (50335741)
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| Co-Investigator(Kenkyū-buntansha) |
古谷 彰 山口大学, 医学部附属病院, 学術研究員 (90346552)
李 桃生 山口大学, 大学院・医学系研究科, 講師 (50379997)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Ischemic preconditioning / 虚血再灌流障害 / 幹細胞 / 骨髄幹細胞 / 虚血プレコンディショニング / Ischemic Preconditioning |
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| Research Abstract |
Ischemic preconditioning is an innate phenomenon in which brief exposure to sublethal ischemia provides tissue protection from ischemia/reperfusion injury. But the precise mechanisms of organ protection by ischemic preconditioning are unclear. This study shows that the enhanced mobilization and recruitment of bone marrow stem cells play an important role in the late phase of ischemic preconditioning.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase.2009
Author(s)
Kamota T, Li TS, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Ikeda Y, Matsuzaki M, Hamano K.
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Journal Title
J Am Coll Cardiol. 53(19)
Pages: 1814-22
Related Report
Peer Reviewed
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[Presentation] Ischemic preconditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase2008
Author(s)
Kamota T, Li TS,, Morikage N, Murakami M, Ohshima M, Kubo M, Kobayashi T, Mikamo A, Hamano K
Organizer
American Heart Association Scientific Sessions 2008
Place of Presentation
New Orleans, Ernest N. Morial Convention Center, USA
Year and Date
2008-11-10
Related Report
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