Protective effects of cold spinoplegia with fasudi I against ischemic spinal cord injury in rabbits

• Project/Area Number: 20591650
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyushu University
• Principal Investigator: NAKASHIMA Atsuhiro Kyushu University, 九州大学病院, 助教 (10260704)
• Co-Investigator(Kenkyū-buntansha): TANOUE Yoshihisa 九州大学, 病院, 助教 (40372742)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 脊髄虚血 / rho-kinase inhibitor / 虚血再潅流障害 / spiuoplegia / spinoplegia

Research Abstract

This study has revealed that fasudil has a neuroprotective effect against ischemic spinal cord injury in rabbits. Inhibition of the Rho/Rho kinase pathway by fasudil reduces the number of infiltrating cells in the ventral horn and prolongs the expression of eNOS. In the near future, ROCK may be an important therapeutic target for paraplegia induced by spinal cord ischemia.

Research Products

• [Presentation] ウサギの脊髄虚血モデルによる対麻痺に対するRho-kinase阻害薬の有効性の検討 (2008)
  • Author(s): 馬場啓徳, 田ノ上禎久, 木村聡, 小田晋一郎, 小林真理子, 前田武俊, 富永隆治
  • Organizer: 日本心臓血管外科学会総会
  • Place of Presentation: 福岡
• [Presentation] ウサギの脊髄虚血モデルによる対麻痺に対するRho-kinase阻害薬の有効性の検討 (2007)
  • Author(s): 馬場啓徳, 田ノ上禎久, 小田晋一郎, 小林真理子, 前田武俊, 富永隆治
  • Organizer: 日本循環器学会九州地方会
  • Place of Presentation: 別府
• [Remarks] ホームページ等
  • URL: http://csl.med.kyushu-u.ac.jp/