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Improvement of the stabilization on the target coronary artery motion by 3-dimensional digital motion capture and reconstruction technology.

Research Project

Project/Area Number 20591651
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionFukushima Medical University

Principal Investigator

YOKOYAMA Hitoshi  Fukushima Medical University, 医学部, 教授 (80282127)

Co-Investigator(Kenkyū-buntansha) TAKASE Shinya  福島県立医科大学, 医学部, 講師 (30347223)
WAKAMATSU Hiroki  福島県立医科大学, 医学部, 講師 (50443875)
三澤 幸辰  福島県立医科大学, 医学部, 博士研究員 (50381405)
Co-Investigator(Renkei-kenkyūsha) OMATA Sadao  日本大学, 工学部, 教授 (90060186)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords外科 / 心臓 / 心拍動下手術 / 3次元デジタル解析システム / レミフェンタニル / ノルアドレナリン / フェニレフリン / ランジオロール / 冠動脈運動 / Off nump coronary artery bypass / Three dimensional movement analysis / Stabilization / β adrenegic recentor blocker
Research Abstract

Adequate stabilization of anastomosis sites during off-pump coronary artery bypass is essential to obtain excellent graft patency. We examined the effect of several drugs and mechanical ventilation on the target coronary artery motion by three-dimensional digital motion capture and reconstruction technology.
Selective beta-1 receptor blockade significantly reduces the three dimensional motion at anastomosis sites on the beating heart.
Low volume or postponement of ventilation might be beneficial to excellent coronary artery stabilization during OPCAB surgery.
The heart rate during remifentanil infusion significantly decreased at all stabilized areas. But we revealed that target coronary artery motion under mechanical stabilizers does not increase after remifentanil administration.
Noradrenarine significantly increases target coronary artery motion under a beating heart, whereas Phenylephrine does not. Phenylephrine is apparently more suitable for treating hypotension that develops during OPCAB.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2011 2010 2009 2008

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (14 results) Book (1 results)

  • [Journal Article] Selective beta-1 receptor blockade further reduces the mechanically stabilized target coronary artery motion during beating heart surgery.2010

    • Author(s)
      Wakamatsu H, Yokoyama H
    • Journal Title

      Innovations 5

      Pages: 349-354

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Landiolol reduces coronary artery motion in an open chest porcine model : Implication for off-pump coronary artery bypass surgery.2010

    • Author(s)
      Wakamatsu H, Yokoyama H
    • Journal Title

      Gen Thorac Cardiovasc Surg 63

      Pages: 764-768

    • NAID

      10030230985

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-term and long-term outcome of the octogenerians after off-pump coronary artery bypass surgery.2010

    • Author(s)
      Takase S, Wakamatsu H, Yokoyama H
    • Journal Title

      Gen Thorac Cardiovasc Surg 58

      Pages: 561-567

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of endovascular laser treatment for varicose veins with high ligation using pulse mode and without high ligation using continuous mode and lower energy.2010

    • Author(s)
      Satokawa H, Yokoyama H, Wakamatsu H, Igarashi T.
    • Journal Title

      Ann Vasc Dis 3

      Pages: 46-51

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective beta-1 receptor blockade further reduces the mechanically stabilized target coronary artery motion during beating heart surgery.2010

    • Author(s)
      若松大樹
    • Journal Title

      Innovations

      Volume: 5(5) Pages: 349-354

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short- and long-term outcome of the octogenarians after off-pump coronary artery bypass surgery.2010

    • Author(s)
      高瀬信弥
    • Journal Title

      Gen Thorac Cardiovasc Surg

      Volume: 58(11) Pages: 561-567

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 塩酸landiolol術中投与によるOPCAB術後心房細動予防効果の検討2010

    • Author(s)
      若松大樹
    • Journal Title

      胸部外科

      Volume: 63(9) Pages: 764-765

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合的CABGアルゴリズムによるOPCAB安全性の向上:ラーニングカーブ初期からの戦略と手技2009

    • Author(s)
      横山斉
    • Journal Title

      胸部外科 62

      Pages: 28-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aortic arch repair with coronary artery revascularization.2009

    • Author(s)
      Wakamatsu H, Sato Y, Takase S, Sato Y, Satokawa H, Yokoyama H
    • Journal Title

      Fukushima J Med Aci 55

      Pages: 52-60

    • NAID

      10031185698

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological cardiac stabilization during off-pump coronary artery bypass : Effects of landiolol hydrochloride, a novel short-acting β1 receptor antagonist (心拍動下冠動脈バイパス術における超短時間作用型β1遮断薬(ランジオロールハイドロクロライド)を用いた薬理学的心表面固定法の評価)2009

    • Author(s)
      若松大樹
    • Journal Title

      学位論文内容及び審査結果の要旨 第46集

      Pages: 31-32

    • Related Report
      2009 Annual Research Report
  • [Presentation] OPCAB中の心表面冠動脈運動に対するフェニレフリン及びノルアドレナリンの影響2011

    • Author(s)
      黒澤博之
    • Organizer
      第41回日本心臓血管外科学会学術総会
    • Place of Presentation
      舞浜
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 心拍動下冠動脈バイパス術におけるremifen-tanilの心表面運動に対する影響の検討2011

    • Author(s)
      瀬戸夕輝
    • Organizer
      第41回日本心臓血管外科学会学術総会
    • Place of Presentation
      舞浜
    • Year and Date
      2011-02-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベータブロッカーによるCABG治療成績向上の試み2010

    • Author(s)
      横山斉
    • Organizer
      周術期β1遮断薬セミナー
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 冠動脈バイパス術の戦略と成績-最新のRCTを考える-2010

    • Author(s)
      横山斉
    • Organizer
      和歌山循環器治療セミナー
    • Place of Presentation
      和歌山
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 「我が国のCABGの現況:標準術式としてのOPCABの成績からガイドラインを再考する」:日本冠疾患学会・冠動脈外科学会ジョイントシンポジウム「冠血行再建のより良いガイドラインにむけて」2010

    • Author(s)
      横山斉
    • Organizer
      第15回日本冠動脈外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 「我が国のCABGの現況:標準術式としてのOPCABの成績からガイドラインを再考する」:日本冠疾患学会・冠動脈外科学会ジョイントシンポジウム「冠血行再建のより良いガイドラインに向けて」2010

    • Author(s)
      横山斉
    • Organizer
      第15回日本冠動脈外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Roles of beta1-blocker during off-pump coronary artery bypass2010

    • Author(s)
      横山斉
    • Organizer
      Current Seminar in Osaka 2010
    • Place of Presentation
      大阪
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 心臓血管外科の現状と展望2010

    • Author(s)
      横山斉
    • Organizer
      札幌胸部外科フォーラム
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] OPCAB冠動脈吻合:外科医のベストパフォーマンスのために2010

    • Author(s)
      横山斉
    • Organizer
      関西胸部外科学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 心拍動下冠動脈バイパス術の長期成績とその優位性-OPCABを中心とした統合的冠動脈再建法421例の検討から-2010

    • Author(s)
      高瀬信弥、佐戸川弘之、若松大樹、横山斉
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋(シンポジウム)
    • Year and Date
      2010-04-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 心拍動下冠動脈バイパス:βプロッカーによる治療成績向2010

    • Author(s)
      横山斉
    • Organizer
      第40回日本心臓血管外科学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2010-02-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 心拍動下冠動脈バイパス術における超短時間作用型β1遮断薬を用いた薬理学的心表面固定法の評価2009

    • Author(s)
      若松大樹, 佐戸川弘之, 佐藤洋一, 高瀬信弥, 佐藤善之, 瀬戸夕輝, 坪井栄俊, 五十嵐 崇, 山本晃裕, 横山 斉, 尾俣定夫1)
    • Organizer
      第147回日本循環器学会東北地方会
    • Place of Presentation
      仙台
    • Year and Date
      2009-02-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmacological stabilization during off pump coronary artery bypass : Effects of landiolol hydrochloride, a novel short acting beta-receptor antagonist2008

    • Author(s)
      若松大樹, 横山斉, 尾俣定夫(日本大学工学部)
    • Organizer
      福島医学会第415回学術研究集会
    • Place of Presentation
      福島
    • Year and Date
      2008-10-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pharmacological stabilization During Off Pump Coronary Artery Bypass : Effects of Landiolol Hydrochloride, A Novel Short Acting Beta-Receptor Antagonist2008

    • Author(s)
      Hiroki Wakamatsu, Hitoshi Yokoyama
    • Organizer
      International Society for Minimally Invasive Cardiothoracic Surgery
    • Place of Presentation
      Boston
    • Related Report
      2008 Annual Research Report
  • [Book] 福島の進路 No.316発行(「心臓血管外科における最新治療と産学共同研究」)2008

    • Author(s)
      若松大樹
    • Publisher
      (財)福島経済研究所(2008.11.26発行)
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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