Effect of human atrial natriuretic peptide on ischemic spinal cord injury ; therapeutic potential and possible underlying mechanism.
| Project/Area Number |
20591652
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
OKAJIMA Kenji Nagoya City University, 大学院・医学研究科, 教授 (60152295)
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| Co-Investigator(Kenkyū-buntansha) |
HARADA Naoaki 名古屋市立大学, 大学院・医学研究科, 准教授 (00309915)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ヒト心房性ナトリウム利尿ペプチド / 知覚神経 / カルシトニン遺伝子関連ペプチド / インスリン様成長因子-I / 虚血性脊髄障害 / 脊髄障害 / アポトーシス |
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| Research Abstract |
Human atrial natriuretic peptide (ANP) stimulated sensory neurons in vitro. When intravenously administered prior to the insult, ANP reduced ischemic spinal cord injury through attenuation of spinal cord tissue inflammatory responses. However, ANP did not reduce the spinal cord injury, when administered intravenously after the insult. Subcutaneous administration of ANP may exert therapeutic effect on the ischemic spinal cord injury by increasing ANP levels of the injured spinal cord tissue and by stimulating nociceptive pathway, thus showing more marked and longer therapeutic effect on the ischemic spinal cord injury than intravenous ANP administration.
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Report
(4 results)
Research Products
(51 results)
