| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Human atrial natriuretic peptide (ANP) stimulated sensory neurons in vitro. When intravenously administered prior to the insult, ANP reduced ischemic spinal cord injury through attenuation of spinal cord tissue inflammatory responses. However, ANP did not reduce the spinal cord injury, when administered intravenously after the insult. Subcutaneous administration of ANP may exert therapeutic effect on the ischemic spinal cord injury by increasing ANP levels of the injured spinal cord tissue and by stimulating nociceptive pathway, thus showing more marked and longer therapeutic effect on the ischemic spinal cord injury than intravenous ANP administration.
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