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Direct delivery of vascular endothelial growth factor improves heart failure in rats' myocardial infarction model.

Research Project

Project/Area Number 20591655
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionWakayama Medical University

Principal Investigator

TOGUCHI Koji (2010)  Wakayama Medical University, 医学部, 助教 (20549753)

金子 政弘 (2008-2009)  Wakayama Medical University, 医学部, 学内助教 (40433346)

Co-Investigator(Kenkyū-buntansha) KANEKO Masahiro  和歌山県立医科大学, 医学部, 学内助教 (40433346)
HIRAMATSU Takeshi  和歌山県立医科大学, 医学部, 講師 (70221520)
OKAMURA Yoshitaka  和歌山県立医科大学, 医学部, 教授 (80245076)
MAEDA Masanobu  和歌山県立医科大学, 医学部, 教授 (80181593)
WAKI Hidefumi  和歌山県立医科大学, 医学部, 講師 (50274957)
KOHSAKA Akira  和歌山県立医科大学, 医学部, 講師 (00458051)
NISHIMURA Yoshiharu  和歌山県立医科大学, 医学部, 講師 (70254539)
HATADA Atsutoshi  和歌山県立医科大学, 医学部, 助教 (70508027)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords急性心筋梗塞 / 血管内皮増殖因子 / 心不全 / タンパク質導入 / タンパク質治療 / 心筋梗塞 / タンパク質導 / 血管内皮細胞増殖因子
Research Abstract

It was successful that direct delivery of vascular endothelial growth factor(VEGF) into myocardium in acute myocardial infarction rat model. The direct delivery of VEGF reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery of VEGF improved cardiac function.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (3 results)

All 2010 2008

All Presentation (3 results)

  • [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyocytes reduced infarcted areas in acute myocardial infarction rats2010

    • Author(s)
      Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Final Research Report
  • [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyo cytes reduced infarcted areas in acute myocardial infarction rats2010

    • Author(s)
      Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
    • Organizer
      第87回日本生理学会
    • Place of Presentation
      盛岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] Direct delivery of neuronal nitric oxide synthase into myocardium improves heart failure after acute myocardial infarction in rats.2008

    • Author(s)
      Atsutoshi Hatada
    • Organizer
      XXVIII Europian Section Meeting of the international Society for Heart Research
    • Place of Presentation
      Athens
    • Year and Date
      2008-05-29
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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