Direct delivery of vascular endothelial growth factor improves heart failure in rats' myocardial infarction model.

• Project/Area Number: 20591655
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: TOGUCHI Koji (2010) Wakayama Medical University, 医学部, 助教 (20549753); 金子 政弘 (2008-2009) Wakayama Medical University, 医学部, 学内助教 (40433346)
• Co-Investigator(Kenkyū-buntansha): KANEKO Masahiro 和歌山県立医科大学, 医学部, 学内助教 (40433346) ; HIRAMATSU Takeshi 和歌山県立医科大学, 医学部, 講師 (70221520) ; OKAMURA Yoshitaka 和歌山県立医科大学, 医学部, 教授 (80245076) ; MAEDA Masanobu 和歌山県立医科大学, 医学部, 教授 (80181593) ; WAKI Hidefumi 和歌山県立医科大学, 医学部, 講師 (50274957) ; KOHSAKA Akira 和歌山県立医科大学, 医学部, 講師 (00458051) ; NISHIMURA Yoshiharu 和歌山県立医科大学, 医学部, 講師 (70254539) ; HATADA Atsutoshi 和歌山県立医科大学, 医学部, 助教 (70508027)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 急性心筋梗塞 / 血管内皮増殖因子 / 心不全 / タンパク質導入 / タンパク質治療 / 心筋梗塞 / タンパク質導 / 血管内皮細胞増殖因子

Research Abstract

It was successful that direct delivery of vascular endothelial growth factor(VEGF) into myocardium in acute myocardial infarction rat model. The direct delivery of VEGF reduced the size of infarcted area in acute phase after acute myocardial infarction. And then the direct delivery of VEGF improved cardiac function.

Research Products

• [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyocytes reduced infarcted areas in acute myocardial infarction rats (2010)
  • Author(s): Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
• [Presentation] Direct transduction of vascular endothelial growth factor into cardiomyo cytes reduced infarcted areas in acute myocardial infarction rats (2010)
  • Author(s): Masahiro Kaneko, Atsutoshi Hatada, Yoshiharu Nishimura, Shunji Uchita, Koji Toguchi, Kentaro Honda, Takeo Nakai, Hidefumi Waki, Akira Kohsaka, Yoshitaka Okamura, Masanobu Maeda
  • Organizer: 第87回日本生理学会
  • Place of Presentation: 盛岡
• [Presentation] Direct delivery of neuronal nitric oxide synthase into myocardium improves heart failure after acute myocardial infarction in rats. (2008)
  • Author(s): Atsutoshi Hatada
  • Organizer: XXVIII Europian Section Meeting of the international Society for Heart Research
  • Place of Presentation: Athens
  • Year and Date: 2008-05-29